You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
PALB2
Partner and localizer of BRCA2

Protein Summary
Description
Plays a critical role in homologous recombination repair (HRR) through its ability to recruit BRCA2 and RAD51 to DNA breaks (PubMed:16793542, PubMed:19423707, PubMed:19369211, PubMed:22941656, PubMed:24141787, PubMed:28319063). Strongly stimulates the DNA strand-invasion activity of RAD51, stabilizes the nucleoprotein filament against a disruptive BRC3-BRC4 polypeptide and helps RAD51 to overcome the suppressive effect of replication protein A (RPA) (PubMed:20871615). Functionally cooperates with RAD51AP1 in promoting of D-loop formation by RAD51 (PubMed:20871616). Serves as the molecular scaffold in the formation of the BRCA1-PALB2-BRCA2 complex which is essential for homologous recombination (PubMed:19369211). Via its WD repeats is proposed to scaffold a HR complex containing RAD51C and BRCA2 which is thought to play a role in HR-mediated DNA repair (PubMed:24141787). Essential partner of BRCA2 that promotes the localization and stability of BRCA2 (PubMed:16793542). Also enables its ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000261584
  • ENSP00000261584
  • ENSG00000083093

Symbol
  • FANCN
  • FANCN
  • PNCA3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.91
biological term
0.79
transcription factor binding site profile
0.75
phenotype
0.7
cell line
0.66


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 425.01   (req: < 5)
Gene RIFs: 152   (req: <= 3)
Antibodies: 215   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 425.01   (req: >= 5)
Gene RIFs: 152   (req: > 3)
Antibodies: 215   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (150)
MORF4L2
Tbio
Novelty:  0.09897629
p_int:  0.999999968
p_ni:  3.2e-8
Score:  0.867
Data Source:  BioPlex,STRINGDB
MORF4L1
Tbio
Family:  Epigenetic
Novelty:  0.01696001
p_int:  0.999998823
p_ni:  2.8e-8
p_wrong:  0.000001148
Score:  0.912
Data Source:  BioPlex,STRINGDB
MTRF1
Tbio
Family:  Enzyme
Novelty:  0.11037387
p_int:  0.999998396
p_ni:  0.000001588
p_wrong:  1.5e-8
Data Source:  BioPlex
BRCA2
Tbio
Novelty:  0.0002217
Score:  0.999
Data Source:  Reactome,STRINGDB
BRCA1
Tchem
Novelty:  0.00011146
Score:  0.996
Data Source:  Reactome,STRINGDB
RAD51C
Tbio
Novelty:  0.0063568
Score:  0.995
Data Source:  Reactome,STRINGDB
RAD51
Tchem
Novelty:  0.00011516
Score:  0.99
Data Source:  Reactome,STRINGDB
FANCD2
Tbio
Novelty:  0.00316101
Score:  0.989
Data Source:  STRINGDB
FANCI
Tbio
Novelty:  0.01223788
Score:  0.987
Data Source:  STRINGDB
BRIP1
Tbio
Novelty:  0.03886334
Score:  0.987
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (37)
DNA Double-Strand Break Repair (R-HSA-5693532)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
DNA Double-Strand Break Repair
Reactome
DNA Repair
Reactome
HDR through Homologous Recombination (HRR)
Reactome
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)
Reactome
Homologous DNA Pairing and Strand Exchange
Name
Explore in Pharos
Explore in Source
DNA Double-Strand Break Repair
DNA Repair
HDR through Homologous Recombination (HRR)
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)
Homologous DNA Pairing and Strand Exchange
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (11)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean reticulocyte volume
1
1
1
33.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean reticulocyte volume
1
33.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
partner and localizer of BRCA2
VGNC:10131
453988
Macaque
partner and localizer of BRCA2 [Source:HGNC Symbol;Acc:HGNC:26144]
Mouse
MGI:3040695
233826
Rat
RGD:1304759
293452
Dog
partner and localizer of BRCA2
VGNC:44245
608527
Species
Name
OMA
EggNOG
Inparanoid
Chimp
partner and localizer of BRCA2
Macaque
partner and localizer of BRCA2 [Source:HGNC Symbol;Acc:HGNC:26144]
Mouse
Rat
Dog
partner and localizer of BRCA2
Publication Statistics
PubMed Score 425.01
PubMed score by year
PubTator Score 195.22
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title