Tchem PAK6 Serine/threonine-protein kinase PAK 6

Protein Summary

Description

Serine/threonine protein kinase that plays a role in the regulation of gene transcription. The kinase activity is induced by various effectors including AR or MAP2K6/MAPKK6. Phosphorylates the DNA-binding domain of androgen receptor/AR and thereby inhibits AR-mediated transcription. Inhibits also ESR1-mediated transcription. May play a role in cytoskeleton regulation by interacting with IQGAP1. May protect cells from apoptosis through phosphorylation of BAD. This gene represents readthrough transcription between the genes BUB1B (mitotic checkpoint serine/threonine-protein kinase BUB1 beta) and PAK6 (serine/threonine-protein kinase PAK 6). The protein encoded by the readthrough transcripts is the same as the product of the downstream gene (PAK6). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]

Uniprot Accession IDs

• Q9NQU5
• A8K2G2
• B3KYB0
• G5E9R2

Gene Name

• PAK6

Ensembl ID

• ENST00000260404
• ENSP00000260404
• ENSG00000137843
• ENST00000455577
• ENSP00000409465
• ENST00000542403
• ENSP00000439597
• ENST00000560346
• ENSP00000453858

Symbol

• PAK5
• PAK5
• PAK6
• PAK-5
• PAK-6

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.96
hub protein	0.79
protein domain	0.73
transcription factor	0.7
cell type or tissue	0.68

Protein Classes

DTO Classes

Protein / Kinase / Protein Kinase / Ste Group / Ste20 Family / Pakb Subfamily / Serine/threonine-protein Kinase Pak 6

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 52.51   (req: < 5)

Gene RIFs: 26   (req: <= 3)

Antibodies: 494   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 52.51   (req: >= 5)

Gene RIFs: 26   (req: > 3)

Antibodies: 494   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 9

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0