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Tchem
PAK5
Serine/threonine-protein kinase PAK 5

Protein Summary
Description
Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, proliferation or cell survival. Activation by various effectors including growth factor receptors or active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates the proto-oncogene RAF1 and stimulates its kinase activity. Promotes cell survival by phosphorylating the BCL2 antagonist of cell death BAD. Phosphorylates CTNND1, probably to regulate cytoskeletal organization and cell morphology. Keeps microtubules stable through MARK2 inhibition and destabilizes the F-actin network leading to the disappearance of stress fibers and focal adhesions. The protein encoded by this gene is a member of the PAK family of Ser/Thr protein kinases. PAK family members are known to be effectors of Rac/Cdc42 GTPases, which have been implicated in the regulation of cytosk ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000353224
  • ENSP00000322957
  • ENSG00000101349
  • ENST00000378423
  • ENSP00000367679
  • ENST00000378429
  • ENSP00000367686

Symbol
  • KIAA1264
  • PAK7
  • PAK7
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 60.25   (req: < 5)
Gene RIFs: 29   (req: <= 3)
Antibodies: 339   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 60.25   (req: >= 5)
Gene RIFs: 29   (req: > 3)
Antibodies: 339   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 7
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (6)
Dark Kinase Knowledgebase
Thumbnail image for Dark Kinase Knowledgebase
The Dark Kinase Knowledgebase is an an online compendium of knowledge and experimental results of understudied kinases.
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (120)
PAK4
Tchem
Family:  Kinase
Novelty:  0.0068821
p_int:  1
Score:  0.955
Data Source:  BioPlex,STRINGDB
ARHGEF11
Tbio
Novelty:  0.01942359
p_int:  0.999999974
p_ni:  2.6e-8
Score:  0.715
Data Source:  BioPlex,STRINGDB
CARMIL1
Tbio
Novelty:  0.04162135
p_int:  0.999998665
p_ni:  0.000001335
Score:  0.625
Data Source:  BioPlex,STRINGDB
ARHGEF2
Tbio
Novelty:  0.01494954
p_int:  0.999997535
p_ni:  0.000002465
Score:  0.489
Data Source:  BioPlex,STRINGDB
METAP1D
Tbio
Family:  Enzyme
Novelty:  0.17714714
p_int:  0.999995169
p_ni:  0.000004828
p_wrong:  3e-9
Score:  0.161
Data Source:  BioPlex,STRINGDB
TBC1D2B
Tdark
Novelty:  0.52348266
p_int:  0.99997462
p_ni:  0.00002538
Score:  0.206
Data Source:  BioPlex,STRINGDB
TANC2
Tdark
Novelty:  0.08495328
p_int:  0.999971845
p_ni:  0.000028155
Score:  0.284
Data Source:  BioPlex,STRINGDB
OBSL1
Tbio
Novelty:  0.0325947
p_int:  0.999123518
p_ni:  0.000876482
Data Source:  BioPlex
SUPT5H
Tbio
Novelty:  0.00775042
p_int:  0.99327817
p_ni:  0.00672183
Score:  0.16
Data Source:  BioPlex,STRINGDB
AMZ2
Tbio
Family:  Enzyme
Novelty:  0.27424719
p_int:  0.990760377
p_ni:  0.009239623
Score:  0.183
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets (10)
Explore Nearest Tclin Targets
1 – 5 of 8
PIK3CD
Tclin
Family:  Kinase
KEGG Distance:  2
Common Pathways:  8
more:  4 more common pathways
PIK3CA
Tclin
Family:  Kinase
KEGG Distance:  2
Common Pathways:  8
more:  4 more common pathways
BDKRB2
Tclin
Family:  GPCR
KEGG Distance:  2
Common Pathways:  1
CHRM5
Tclin
Family:  GPCR
KEGG Distance:  2
Common Pathways:  1
CHRM1
Tclin
Family:  GPCR
KEGG Distance:  2
Common Pathways:  1
Pathways (42)
Activation of RAC1 (R-HSA-428540)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of RAC1
Reactome
Axon guidance
Reactome
Developmental Biology
Reactome
Signaling by ROBO receptors
Name
Explore in Pharos
Explore in Source
Activation of RAC1
Axon guidance
Developmental Biology
Signaling by ROBO receptors
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
1
1
1
16.8
body weight
1
1
1
11.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
1
16.8
body weight
1
11.4
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
p21 (RAC1) activated kinase 5
VGNC:10301
469876
Macaque
p21 (RAC1) activated kinase 5
719458
Mouse
MGI:1920334
241656
Rat
RGD:1312009
311450
Dog
p21 (RAC1) activated kinase 5
VGNC:53544
485772
Species
Name
OMA
EggNOG
Inparanoid
Chimp
p21 (RAC1) activated kinase 5
Macaque
p21 (RAC1) activated kinase 5
Mouse
Rat
Dog
p21 (RAC1) activated kinase 5
Publication Statistics
PubMed Score 60.25
PubMed score by year
PubTator Score 39.62
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title