PAK4
Serine/threonine-protein kinase PAK 4
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Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
drug perturbation | 1 | ||
interacting protein | 0.98 | ||
molecular function | 0.96 | ||
transcription factor | 0.77 | ||
hub protein | 0.75 | ||
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
- OR - satisfy the following criterion:
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Target has at least one approved drug - AND - satisfies the preceding conditions
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Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Activation of RAC1 | ||||
Reactome | Axon guidance | ||||
Reactome | Developmental Biology | ||||
Reactome | Signaling by ROBO receptors | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Activation of RAC1 | ||||
Axon guidance | ||||
Developmental Biology | ||||
Signaling by ROBO receptors | ||||
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from High Throughput Direct Assay (HDA) | BHF-UCL | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Non-traceable Author Statement (NAS) | ProtInc | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
7 | 3 | 0 | 2.2 | 91.3 | |||||
remission | 3 | 1 | 0 | 2.1 | 84.2 | ||||
3 | 1 | 0 | 2.1 | 84.2 | |||||
mitochondrial heteroplasmy measurement | 1 | 1 | 1 | 56.6 | |||||
viral load | 1 | 1 | 1 | 49.5 | |||||
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
0 | 2.2 | 91.3 | |||||
remission | 0 | 2.1 | 84.2 | ||||
0 | 2.1 | 84.2 | |||||
mitochondrial heteroplasmy measurement | 1 | 56.6 | |||||
viral load | 1 | 49.5 | |||||
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Macaque | p21 (RAC1) activated kinase 4 | 696676 | ||||||
Mouse | MGI:1917834 | 70584 | ||||||
Rat | RGD:1307705 | 292756 | ||||||
Dog | p21 (RAC1) activated kinase 4 | VGNC:53528 | 484513 | |||||
Horse | p21 (RAC1) activated kinase 4 [Source:HGNC Symbol;Acc:HGNC:16059] | |||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Macaque | p21 (RAC1) activated kinase 4 | |||||
Mouse | ||||||
Rat | ||||||
Dog | p21 (RAC1) activated kinase 4 | |||||
Horse | p21 (RAC1) activated kinase 4 [Source:HGNC Symbol;Acc:HGNC:16059] | |||||
PMID | Year | Title |
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