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Tchem
PAK4
Serine/threonine-protein kinase PAK 4

Protein Summary
Description
Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, growth, proliferation or cell survival. Activation by various effectors including growth factor receptors or active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates and inactivates the protein phosphatase SSH1, leading to increased inhibitory phosphorylation of the actin binding/depolymerizing factor cofilin. Decreased cofilin activity may lead to stabilization of actin filaments. Phosphorylates LIMK1, a kinase that also inhibits the activity of cofilin. Phosphorylates integrin beta5/ITGB5 and thus regulates cell motility. Phosphorylates ARHGEF2 and activates the downstream target RHOA that plays a role in the regulation of assembly of focal adhesions and actin stress fibers. Stimulates cell survival by phosphorylating the BCL2 antagonist of cell ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000321944
  • ENSP00000326864
  • ENSG00000130669
  • ENST00000358301
  • ENSP00000351049
  • ENST00000360442
  • ENSP00000353625
  • ENST00000593690
  • ENSP00000469413
  • ENST00000599386
  • ENSP00000471157
  • ENST00000599470
  • ENSP00000470284

Symbol
  • KIAA1142
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug perturbation
1
interacting protein
0.98
molecular function
0.96
transcription factor
0.77
hub protein
0.75


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 225.09   (req: < 5)
Gene RIFs: 93   (req: <= 3)
Antibodies: 572   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 225.09   (req: >= 5)
Gene RIFs: 93   (req: > 3)
Antibodies: 572   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 83
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0