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Tbio
PAIP2B
Polyadenylate-binding protein-interacting protein 2B

Protein Summary
Description
Inhibits translation of capped and polyadenylated mRNAs by displacing PABPC1 from the poly(A) tail. Most mRNAs, except for histones, contain a 3-prime poly(A) tail. Poly(A)-binding protein (PABP; see MIM 604679) enhances translation by circularizing mRNA through its interaction with the translation initiation factor EIF4G1 (MIM 600495) and the poly(A) tail. Various PABP-binding proteins regulate PABP activity, including PAIP1 (MIM 605184), a translational stimulator, and PAIP2A (MIM 605604) and PAIP2B, translational inhibitors (Derry et al., 2006 [PubMed 17381337]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000244221
  • ENSP00000244221
  • ENSG00000124374

Symbol
  • KIAA1155
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.94
disease perturbation
0.9
gene perturbation
0.86
microRNA
0.8
histone modification site profile
0.79


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.4   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 10   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.4   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 10   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (43)
LUC7L2
Tdark
Novelty:  0.36989457
p_int:  0.999720092
p_ni:  0.000279908
Data Source:  BioPlex
DND1
Tbio
Novelty:  0.0287312
p_int:  0.998857689
p_ni:  0.001139862
p_wrong:  0.000002449
Score:  0.228
Data Source:  BioPlex,STRINGDB
ELAVL2
Tbio
Novelty:  0.00370708
p_int:  0.998677779
p_ni:  0.001321618
p_wrong:  6.03e-7
Score:  0.166
Data Source:  BioPlex,STRINGDB
CELF5
Tbio
Novelty:  0.04733002
p_int:  0.992236735
p_ni:  0.003348363
p_wrong:  0.004414901
Score:  0.586
Data Source:  BioPlex,STRINGDB
HNRNPA1
Tchem
Novelty:  0.0020871
p_int:  0.988585138
p_ni:  0.001170306
p_wrong:  0.010244556
Score:  0.181
Data Source:  BioPlex,STRINGDB
CIRBP
Tbio
Novelty:  0.00439066
p_int:  0.98235976
p_ni:  0.013631345
p_wrong:  0.004008895
Score:  0.202
Data Source:  BioPlex,STRINGDB
RBM3
Tbio
Novelty:  0.01066923
p_int:  0.98172179
p_ni:  0.014656992
p_wrong:  0.003621218
Score:  0.201
Data Source:  BioPlex,STRINGDB
SNIP1
Tbio
Novelty:  0.01865867
p_int:  0.947323049
p_ni:  0.014432208
p_wrong:  0.038244743
Data Source:  BioPlex
PABPC1
Tbio
Novelty:  0.00197523
Score:  0.944
Data Source:  STRINGDB
ATP1B3
Tclin
Family:  Transporter
Novelty:  0.06773518
Score:  0.8
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intelligence
3
6
1
6.1
80.3
cognitive function measurement
3
2
3
53.1
heel bone mineral density
1
1
1
49.5
sex hormone-binding globulin measurement
2
1
2
48.5
body height
1
1
1
42.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intelligence
1
6.1
80.3
cognitive function measurement
3
53.1
heel bone mineral density
1
49.5
sex hormone-binding globulin measurement
2
48.5
body height
1
42.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
poly(A) binding protein interacting protein 2B
VGNC:10735
738296
Macaque
poly(A) binding protein interacting protein 2B
711595
Mouse
MGI:2386865
232164
Rat
RGD:1307930
312490
Dog
poly(A) binding protein interacting protein 2B [Source:HGNC Symbol;Acc:HGNC:29200]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
poly(A) binding protein interacting protein 2B
Macaque
poly(A) binding protein interacting protein 2B
Mouse
Rat
Dog
poly(A) binding protein interacting protein 2B [Source:HGNC Symbol;Acc:HGNC:29200]
Publication Statistics
PubMed Score 1.40
PubMed score by year
PubTator Score 1.70
PubTator score by year
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Related Publications
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PMID
Year
Title