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Tbio
PAIP1
Polyadenylate-binding protein-interacting protein 1

Protein Summary
Description
Acts as a coactivator in the regulation of translation initiation of poly(A)-containing mRNAs. Its stimulatory activity on translation is mediated via its action on PABPC1. Competes with PAIP2 for binding to PABPC1. Its association with EIF4A and PABPC1 may potentiate contacts between mRNA termini. May also be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. The protein encoded by this gene interacts with poly(A)-binding protein and with the cap-binding complex eIF4A. It is involved in translational initiation and protein biosynthesis. Overexpression of this gene in COS7 cells stimulates translation. Alternative splicing occurs at this locus and three transcript variants encoding three distinct isoforms have been identified. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000306846
  • ENSP00000302768
  • ENSG00000172239
  • ENST00000338972
  • ENSP00000339622
  • ENST00000436644
  • ENSP00000387729
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.96
gene perturbation
0.81
disease perturbation
0.79
virus perturbation
0.76
kinase perturbation
0.71


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.07   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 188   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.07   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 188   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (145)
PABPC1L
Tbio
Novelty:  0.04037574
p_int:  0.999999997
p_wrong:  3e-9
Score:  0.964
Data Source:  BioPlex,STRINGDB
MKRN2
Tbio
Family:  Enzyme
Novelty:  0.14061051
p_int:  0.99936405
p_ni:  0.000568425
p_wrong:  0.000067525
Score:  0.764
Data Source:  BioPlex,STRINGDB
ELAVL2
Tbio
Novelty:  0.00370708
p_int:  0.976682289
p_ni:  0.023317711
Score:  0.585
Data Source:  BioPlex,STRINGDB
ZCCHC3
Tdark
Novelty:  0.47687468
p_int:  0.948295295
p_ni:  0.051704705
Score:  0.735
Data Source:  BioPlex,STRINGDB
HNRNPDL
Tbio
Novelty:  0.00222179
p_int:  0.930215793
p_ni:  0.069784207
Score:  0.498
Data Source:  BioPlex,STRINGDB
H2AFX
Tbio
Novelty:  0.00048694
p_int:  0.929520904
p_ni:  0.001539719
p_wrong:  0.068939377
Score:  0.644
Data Source:  BioPlex,STRINGDB
LARP4B
Tbio
Novelty:  0.11363794
p_int:  0.908843084
p_ni:  0.09115567
p_wrong:  0.000001246
Data Source:  BioPlex
CELF5
Tbio
Novelty:  0.04733002
p_int:  0.908537649
p_ni:  0.091462351
Score:  0.547
Data Source:  BioPlex,STRINGDB
STAU2
Tbio
Novelty:  0.03802876
p_int:  0.907094837
p_ni:  0.092905163
Score:  0.518
Data Source:  BioPlex,STRINGDB
TRA2A
Tbio
Novelty:  0.04935993
p_int:  0.855369255
p_ni:  0.144630741
p_wrong:  4e-9
Score:  0.317
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Deadenylation of mRNA (R-HSA-429947)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Deadenylation of mRNA
Reactome
Deadenylation-dependent mRNA decay
Reactome
Metabolism of RNA
Name
Explore in Pharos
Explore in Source
Deadenylation of mRNA
Deadenylation-dependent mRNA decay
Metabolism of RNA
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
2
2
2
68.1
mathematical ability
1
1
1
57.3
lymphocyte count
1
1
1
57.3
leukocyte count
1
1
1
35
self reported educational attainment
1
1
1
33.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
2
68.1
mathematical ability
1
57.3
lymphocyte count
1
57.3
leukocyte count
1
35
self reported educational attainment
1
33.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
poly(A) binding protein interacting protein 1
700869
Mouse
MGI:2384993
218693
Rat
RGD:1305668
365684
Horse
poly(A) binding protein interacting protein 1
100064807
Cow
poly(A) binding protein interacting protein 1
510246
Species
Name
OMA
EggNOG
Inparanoid
Macaque
poly(A) binding protein interacting protein 1
Mouse
Rat
Horse
poly(A) binding protein interacting protein 1
Cow
poly(A) binding protein interacting protein 1
Publication Statistics
PubMed Score 17.07
PubMed score by year
PubTator Score 9.74
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title