PAICS
Multifunctional protein ADE2
Protein Summary
This gene encodes a bifunctional enzyme containing phosphoribosylaminoimidazole carboxylase activity in its N-terminal region and phosphoribosylaminoimidazole succinocarboxamide synthetase in its C-terminal region. It catalyzes steps 6 and 7 of purine biosynthesis. The gene is closely linked and divergently transcribed with a locus that encodes an enzyme in the same pathway, and transcription of the two genes is coordinately regulated. The human genome contains several pseudogenes of this gene. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
- ENST00000264221
- ENSP00000264221
- ENSG00000128050
- ENST00000399688
- ENSP00000382595
- ENST00000512576
- ENSP00000421096
- ADE2
- AIRC
- PAIS
- ADE2
- AIRC
- PAIS
- ADE2H1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
interacting protein | 1 | ||
kinase perturbation | 1 | ||
molecular function | 0.95 | ||
hub protein | 0.94 | ||
transcription factor binding site profile | 0.9 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 427.79 (req: < 5)
Gene RIFs: 14 (req: <= 3)
Antibodies: 291 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 427.79 (req: >= 5)
Gene RIFs: 14 (req: > 3)
Antibodies: 291 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 9
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 38
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0