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Tbio
PAGE4
P antigen family member 4

Protein Summary
Description
This gene is a member of the GAGE family. The GAGE genes are expressed in a variety of tumors and in some fetal and reproductive tissues. This gene is strongly expressed in prostate and prostate cancer. It is also expressed in other male and female reproductive tissues including testis, fallopian tube, uterus, and placenta, as well as in testicular cancer and uterine cancer. The protein encoded by this gene shares sequence similarity with other GAGE/PAGE proteins, and also belongs to a family of CT (cancer-testis) antigens. The protein may play a role in benign and malignant prostate diseases. A related pseudogene is located on chromosome 7. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000218068
  • ENSP00000218068
  • ENSG00000101951
  • ENST00000376141
  • ENSP00000365311

Symbol
  • GAGEC1
  • JM27
  • JM-27
  • CT16.7
  • GAGE-9
  • GAGEC1
  • PAGE-1
  • PAGE-4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.52
cell line
0.46
biological term
0.36
co-expressed gene
0.35
interacting protein
0.31


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.31   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 85   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.31   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 85   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (17)
TNKS2
Tchem
Family:  Enzyme
Novelty:  0.00938509
p_int:  0.999999971
p_ni:  2.9e-8
Data Source:  BioPlex
TNKS
Tchem
Family:  Enzyme
Novelty:  0.00404545
p_int:  0.999999913
p_ni:  8.7e-8
Data Source:  BioPlex
HIPK1
Tchem
Family:  Kinase
Novelty:  0.11377215
Score:  0.841
Data Source:  STRINGDB
CLK2
Tchem
Family:  Kinase
Novelty:  0.13068449
Score:  0.743
Data Source:  STRINGDB
XAGE1A
Tbio
Novelty:  0.04421526
Score:  0.565
Data Source:  STRINGDB
JUN
Tchem
Family:  TF
Novelty:  0.00006856
Score:  0.515
Data Source:  STRINGDB
GAGE12I
Tbio
Novelty:  0.01850125
Score:  0.512
Data Source:  STRINGDB
GAGE12F
Tdark
Novelty:  0.01850125
Score:  0.512
Data Source:  STRINGDB
GAGE7
Tbio
Novelty:  0.0195995
Score:  0.497
Data Source:  STRINGDB
GAGE12G
Tbio
Novelty:  0.0195995
Score:  0.497
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (0)
No GO Terms found
Disease Associations ()
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (4)
1 – 4 of 4
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
PAGE family member 4
VGNC:2688
107966367
Macaque
PAGE family member 4
693847
Cow
PAGE family member 4
VGNC:50182
505725
Pig
P antigen family member 4
100513450
Species
Name
OMA
EggNOG
Inparanoid
Chimp
PAGE family member 4
Macaque
PAGE family member 4
Cow
PAGE family member 4
Pig
P antigen family member 4
Publication Statistics
PubMed Score 27.31
PubMed score by year
PubTator Score 30.46
PubTator score by year
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Related Publications
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PMID
Year
Title