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Tbio
PAG1
Phosphoprotein associated with glycosphingolipid-enriched microdomains 1

Protein Summary
Description
Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling. The protein encoded by this gene is a type III transmembrane adaptor protein that binds to the tyrosine kinase csk protein. It is thought to be involved in the regulation of T cell activation. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000220597
  • ENSP00000220597
  • ENSG00000076641

Symbol
  • CBP
  • PAG
  • CBP
  • PAG
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.96
kinase perturbation
0.91
hub protein
0.79
microRNA
0.77
drug perturbation
0.71


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 78.08   (req: < 5)
Gene RIFs: 24   (req: <= 3)
Antibodies: 320   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 78.08   (req: >= 5)
Gene RIFs: 24   (req: > 3)
Antibodies: 320   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (131)
CLPB
Tbio
Family:  Enzyme
Novelty:  0.00209789
p_int:  0.999977888
p_ni:  0.000022112
Data Source:  BioPlex
CSK
Tchem
Family:  Kinase
Novelty:  0.00186612
p_int:  0.997275623
p_ni:  0.002724376
Score:  0.997
Data Source:  BioPlex,Reactome,STRINGDB
GJB7
Tbio
Novelty:  0.12555147
p_int:  0.997044075
p_ni:  0.002955924
p_wrong:  1e-9
Data Source:  BioPlex
CYP2S1
Tbio
Novelty:  0.02967417
p_int:  0.996551685
p_ni:  0.003447529
p_wrong:  7.86e-7
Data Source:  BioPlex
ACBD7
Tdark
Novelty:  0.32019061
p_int:  0.990148026
p_ni:  0.009851971
p_wrong:  3e-9
Data Source:  BioPlex
RABIF
Tbio
Novelty:  0.22512579
p_int:  0.976029409
p_ni:  0.02396174
p_wrong:  0.000008851
Data Source:  BioPlex
PCDHGC3
Tbio
Novelty:  0.07203024
p_int:  0.972568958
p_ni:  0.027431042
Data Source:  BioPlex
CCR1
Tchem
Family:  GPCR
Novelty:  0.00218065
p_int:  0.968151208
p_ni:  0.031834441
p_wrong:  0.000014351
Score:  0.219
Data Source:  BioPlex,STRINGDB
HOXB5
Tbio
Family:  TF
Novelty:  0.01119871
p_int:  0.967595673
p_ni:  0.032402756
p_wrong:  0.00000157
Data Source:  BioPlex
SLC25A41
Tdark
Family:  Transporter
Novelty:  1.04918395
p_int:  0.963287212
p_ni:  0.036711319
p_wrong:  0.000001469
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (15)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
GAB1 signalosome
Reactome
Immune System
Reactome
Phosphorylation of CD3 and TCR zeta chains
Reactome
Signal Transduction
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
GAB1 signalosome
Immune System
Phosphorylation of CD3 and TCR zeta chains
Signal Transduction
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte count
1
1
1
15.6
monocyte percentage of leukocytes
1
1
1
13.2
blood protein measurement
1
1
1
13.1
blood urea nitrogen measurement
1
1
1
6.5
aspartate aminotransferase measurement
1
1
0
5.6
1.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte count
1
15.6
monocyte percentage of leukocytes
1
13.2
blood protein measurement
1
13.1
blood urea nitrogen measurement
1
6.5
aspartate aminotransferase measurement
0
5.6
1.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
phosphoprotein membrane anchor with glycosphingolipid microdomains 1
VGNC:13199
464253
Macaque
phosphoprotein membrane anchor with glycosphingolipid microdomains 1
700748
Mouse
MGI:2443160
94212
Rat
RGD:620394
64019
Dog
phosphoprotein membrane anchor with glycosphingolipid microdomains 1
VGNC:44242
610895
Species
Name
OMA
EggNOG
Inparanoid
Chimp
phosphoprotein membrane anchor with glycosphingolipid microdomains 1
Macaque
phosphoprotein membrane anchor with glycosphingolipid microdomains 1
Mouse
Rat
Dog
phosphoprotein membrane anchor with glycosphingolipid microdomains 1
Publication Statistics
PubMed Score 78.08
PubMed score by year
PubTator Score 59.73
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title