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Tbio
PAFAH1B3
Platelet-activating factor acetylhydrolase IB subunit gamma

Protein Summary
Description
Inactivates paf by removing the acetyl group at the sn-2 position. This is a catalytic subunit. Plays an important role during the development of brain. This gene encodes an acetylhydrolase that catalyzes the removal of an acetyl group from the glycerol backbone of platelet-activating factor. The encoded enzyme is a subunit of the platelet-activating factor acetylhydrolase isoform 1B complex, which consists of the catalytic beta and gamma subunits and the regulatory alpha subunit. This complex functions in brain development. A translocation between this gene on chromosome 19 and the CDC-like kinase 2 gene on chromosome 1 has been observed, and was associated with cognitive disability, ataxia, and atrophy of the brain. Alternatively spliced transcript variants have been described. [provided by RefSeq, Mar 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262890
  • ENSP00000262890
  • ENSG00000079462
  • ENST00000538771
  • ENSP00000444935

Symbol
  • PAFAHG
  • PAFAHG
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.86
interacting protein
0.82
kinase perturbation
0.71
gene perturbation
0.65
transcription factor binding site profile
0.65


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.61   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 225   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.61   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 225   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (76)
PAFAH1B1
Tbio
Family:  Enzyme
Novelty:  0.00256206
p_int:  0.967764622
p_ni:  0.032235378
Score:  0.998
Data Source:  BioPlex,Reactome,STRINGDB
PAFAH1B2
Tchem
Family:  Enzyme
Novelty:  0.07918203
Score:  0.99
Data Source:  Reactome,STRINGDB
VLDLR
Tbio
Novelty:  0.00352547
Score:  0.967
Data Source:  STRINGDB
RELN
Tbio
Novelty:  0.005326
Score:  0.936
Data Source:  STRINGDB
DAB1
Tbio
Novelty:  0.08538222
Score:  0.911
Data Source:  STRINGDB
PAFAH2
Tbio
Family:  Enzyme
Novelty:  0.19881779
Score:  0.884
Data Source:  STRINGDB
PLA2G7
Tchem
Family:  Enzyme
Novelty:  0.00270949
Score:  0.837
Data Source:  STRINGDB
LPCAT1
Tbio
Family:  Enzyme
Novelty:  0.01441133
Score:  0.835
Data Source:  STRINGDB
LPCAT2
Tbio
Family:  Enzyme
Novelty:  0.02794035
Score:  0.813
Data Source:  STRINGDB
LPCAT4
Tdark
Family:  Enzyme
Novelty:  0.246654
Score:  0.8
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (8)
COPI-independent Golgi-to-ER retrograde traffic (R-HSA-6811436)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
COPI-independent Golgi-to-ER retrograde traffic
Reactome
Golgi-to-ER retrograde transport
Reactome
Intra-Golgi and retrograde Golgi-to-ER traffic
Reactome
Membrane Trafficking
Reactome
Vesicle-mediated transport
Name
Explore in Pharos
Explore in Source
COPI-independent Golgi-to-ER retrograde traffic
Golgi-to-ER retrograde transport
Intra-Golgi and retrograde Golgi-to-ER traffic
Membrane Trafficking
Vesicle-mediated transport
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (13)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte count
2
1
2
78.4
1
1
1
53.7
balding measurement
1
1
1
45.7
mean corpuscular hemoglobin concentration
1
1
1
39.6
chronotype measurement
1
1
1
35
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte count
2
78.4
1
53.7
balding measurement
1
45.7
mean corpuscular hemoglobin concentration
1
39.6
chronotype measurement
1
35
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
platelet activating factor acetylhydrolase 1b catalytic subunit 3
VGNC:3623
456074
Macaque
platelet activating factor acetylhydrolase 1b catalytic subunit 3
707570
Mouse
MGI:108414
18476
Rat
RGD:620333
114113
Dog
platelet activating factor acetylhydrolase 1b catalytic subunit 3
VGNC:44240
476449
Species
Name
OMA
EggNOG
Inparanoid
Chimp
platelet activating factor acetylhydrolase 1b catalytic subunit 3
Macaque
platelet activating factor acetylhydrolase 1b catalytic subunit 3
Mouse
Rat
Dog
platelet activating factor acetylhydrolase 1b catalytic subunit 3
Publication Statistics
PubMed Score 12.61
PubMed score by year
PubTator Score 7.98
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title