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Tbio
PAFAH1B1
Platelet-activating factor acetylhydrolase IB subunit alpha

Protein Summary
Description
Required for proper activation of Rho GTPases and actin polymerization at the leading edge of locomoting cerebellar neurons and postmigratory hippocampal neurons in response to calcium influx triggered via NMDA receptors. Non-catalytic subunit of an acetylhydrolase complex which inactivates platelet-activating factor (PAF) by removing the acetyl group at the SN-2 position (By similarity). Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. Required during brain development for the proliferation of neuronal precursors and the migration of newly formed neurons from the ventricular/subventricular zone toward the cortical plate. Neuronal migration in ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000397195
  • ENSP00000380378
  • ENSG00000007168

Symbol
  • LIS1
  • MDCR
  • MDS
  • PAFAHA
  • MDS
  • LIS1
  • LIS2
  • MDCR
  • NudF
  • PAFAH
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
transcription factor perturbation
1
disease perturbation
0.99
virus perturbation
0.94
protein domain
0.92


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 93.67   (req: < 5)
Gene RIFs: 63   (req: <= 3)
Antibodies: 286   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 93.67   (req: >= 5)
Gene RIFs: 63   (req: > 3)
Antibodies: 286   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 60
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (407)
NDEL1
Tbio
Novelty:  0.01241819
p_int:  0.999984197
p_ni:  0.000015803
Score:  0.999
Data Source:  BioPlex,STRINGDB
PAFAH1B3
Tbio
Family:  Enzyme
Novelty:  0.10517347
p_int:  0.967764622
p_ni:  0.032235378
Score:  0.998
Data Source:  BioPlex,Reactome,STRINGDB
NDE1
Tbio
Novelty:  0.00567438
Score:  0.998
Data Source:  STRINGDB
DYNC1H1
Tbio
Novelty:  0.0098543
Score:  0.997
Data Source:  Reactome,STRINGDB
DCTN1
Tbio
Novelty:  0.00494896
Score:  0.997
Data Source:  Reactome,STRINGDB
PAFAH1B2
Tchem
Family:  Enzyme
Novelty:  0.07918203
Score:  0.996
Data Source:  Reactome,STRINGDB
NUDC
Tbio
Novelty:  0.01706012
Score:  0.995
Data Source:  STRINGDB
CLIP1
Tbio
Novelty:  0.00399891
Score:  0.991
Data Source:  STRINGDB
DCTN2
Tbio
Novelty:  0.01045432
Score:  0.99
Data Source:  Reactome,STRINGDB
BICD2
Tbio
Novelty:  0.01725046
Score:  0.985
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (39)
AURKA Activation by TPX2 (R-HSA-8854518)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 33
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
AURKA Activation by TPX2
Reactome
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Reactome
Amplification of signal from the kinetochores
Reactome
Anchoring of the basal body to the plasma membrane
Reactome
COPI-independent Golgi-to-ER retrograde traffic
Name
Explore in Pharos
Explore in Source
AURKA Activation by TPX2
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Amplification of signal from the kinetochores
Anchoring of the basal body to the plasma membrane
COPI-independent Golgi-to-ER retrograde traffic
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (79)
Find Similar Targets
Items per page:
10
1 – 10 of 10
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (15)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neuroticism measurement
4
7
3
6.1
84
wellbeing measurement
2
3
3
74.5
depressive symptom measurement
1
2
2
66.6
mean platelet volume
2
2
2
53
anxiety measurement
1
1
1
52.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neuroticism measurement
3
6.1
84
wellbeing measurement
3
74.5
depressive symptom measurement
2
66.6
mean platelet volume
2
53
anxiety measurement
1
52.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (18)
1 – 5 of 18
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
platelet activating factor acetylhydrolase 1b regulatory subunit 1
VGNC:9502
454422
Macaque
platelet activating factor acetylhydrolase 1b regulatory subunit 1
574255
Mouse
MGI:109520
18472
Rat
RGD:620331
83572
Dog
platelet activating factor acetylhydrolase 1b regulatory subunit 1
VGNC:44239
480656
Species
Name
OMA
EggNOG
Inparanoid
Chimp
platelet activating factor acetylhydrolase 1b regulatory subunit 1
Macaque
platelet activating factor acetylhydrolase 1b regulatory subunit 1
Mouse
Rat
Dog
platelet activating factor acetylhydrolase 1b regulatory subunit 1
Publication Statistics
PubMed Score 93.67
PubMed score by year
PubTator Score 279.75
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title