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Tbio
PADI6
Protein-arginine deiminase type-6

Protein Summary
Description
Catalyzes the deimination of arginine residues of proteins (By similarity). May be involved in cytoskeletal reorganization in the egg and early embryo (PubMed:27545678). This gene encodes a member of the peptidyl arginine deiminase family of enzymes, which catalyze the post-translational deimination of proteins by converting arginine residues into citrullines in the presence of calcium ions. The family members have distinct substrate specificities and tissue-specific expression patterns. This protein may play a role in cytoskeletal reorganization in the egg and in early embryo development. [provided by RefSeq, Sep 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000619609
  • ENSP00000483125
  • ENSG00000276747
  • ENST00000625380
  • ENSP00000485805
  • ENSG00000280949

Symbol
  • PAD6
  • hPADVI
  • PREMBL2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.73
cell type or tissue
0.63
biological process
0.54
metabolite
0.45
PubMedID
0.43


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 61.15   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 82   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 61.15   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 82   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (25)
NPM2
Tbio
Novelty:  0.03674672
Score:  0.753
Data Source:  STRINGDB
TLE6
Tbio
Novelty:  0.07734594
Score:  0.707
Data Source:  STRINGDB
OOEP
Tdark
Novelty:  0.14534507
Score:  0.707
Data Source:  STRINGDB
NLRP5
Tbio
Novelty:  0.02441137
Score:  0.657
Data Source:  STRINGDB
TCHH
Tbio
Novelty:  0.00303837
Score:  0.622
Data Source:  STRINGDB
FIGLA
Tbio
Family:  TF
Novelty:  0.02544697
Score:  0.619
Data Source:  STRINGDB
PNMA6A
Tbio
Novelty:  0.05538258
Score:  0.595
Data Source:  STRINGDB
KHDC3L
Tbio
Novelty:  0.0343295
Score:  0.589
Data Source:  STRINGDB
ZAR1L
Tdark
Novelty:  0.08793345
Score:  0.588
Data Source:  STRINGDB
ZAR1
Tbio
Novelty:  0.02026945
Score:  0.58
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Chromatin modifying enzymes (R-HSA-3247509)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chromatin modifying enzymes
Reactome
Chromatin organization
Name
Explore in Pharos
Explore in Source
Chromatin modifying enzymes
Chromatin organization
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
6
4
1
1.3
99.4
6
4
3
1.1
97
hair shape measurement
1
1
1
86.5
keratinocyte carcinoma
1
1
0
1.1
85.5
non-melanoma skin carcinoma
1
1
0
1.2
82.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1.3
99.4
3
1.1
97
hair shape measurement
1
86.5
keratinocyte carcinoma
0
1.1
85.5
non-melanoma skin carcinoma
0
1.2
82.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
peptidyl arginine deiminase 6
700933
Mouse
MGI:2655198
242726
Rat
RGD:1560424
298595
Dog
peptidyl arginine deiminase 6
VGNC:44238
487413
Horse
peptidyl arginine deiminase 6
VGNC:21131
100053017
Species
Name
OMA
EggNOG
Inparanoid
Macaque
peptidyl arginine deiminase 6
Mouse
Rat
Dog
peptidyl arginine deiminase 6
Horse
peptidyl arginine deiminase 6
Publication Statistics
PubMed Score 61.15
PubMed score by year
PubTator Score 6.28
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title