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Tbio
PACSIN1
Protein kinase C and casein kinase substrate in neurons protein 1

Protein Summary
Description
Plays a role in the reorganization of the microtubule cytoskeleton via its interaction with MAPT; this decreases microtubule stability and inhibits MAPT-induced microtubule polymerization. Plays a role in cellular transport processes by recruiting DNM1, DNM2 and DNM3 to membranes. Plays a role in the reorganization of the actin cytoskeleton and in neuron morphogenesis via its interaction with COBL and WASL, and by recruiting COBL to the cell cortex. Plays a role in the regulation of neurite formation, neurite branching and the regulation of neurite length. Required for normal synaptic vesicle endocytosis; this process retrieves previously released neurotransmitters to accommodate multiple cycles of neurotransmission. Required for normal excitatory and inhibitory synaptic transmission (By similarity). Binds to membranes via its F-BAR domain and mediates membrane tubulation.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000244458
  • ENSP00000244458
  • ENSG00000124507
  • ENST00000538621
  • ENSP00000439639
  • ENST00000620693
  • ENSP00000484060

Symbol
  • KIAA1379
  • SDPI
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor
0.74
biological process
0.63
histone modification site profile
0.6
PubMedID
0.6
microRNA
0.59


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 69.61   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 246   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 69.61   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 246   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (196)
COBLL1
Tbio
Novelty:  0.09264701
p_int:  1
Score:  0.933
Data Source:  BioPlex,STRINGDB
COBL
Tbio
Novelty:  0.01903038
p_int:  0.999999729
p_ni:  2.69e-7
p_wrong:  2e-9
Score:  0.929
Data Source:  BioPlex,STRINGDB
PACSIN2
Tbio
Family:  Enzyme
Novelty:  0.0250489
p_int:  0.999999019
p_ni:  9.81e-7
Score:  0.982
Data Source:  BioPlex,STRINGDB
MPRIP
Tbio
Family:  Enzyme
Novelty:  0.03253403
p_int:  0.999987679
p_ni:  0.000012321
Score:  0.663
Data Source:  BioPlex,STRINGDB
RAI14
Tbio
Novelty:  0.06291577
p_int:  0.999972946
p_ni:  0.000027054
p_wrong:  1e-9
Score:  0.87
Data Source:  BioPlex,STRINGDB
PACSIN3
Tbio
Family:  Enzyme
Novelty:  0.11715903
p_int:  0.999921313
p_ni:  0.000078687
Score:  0.993
Data Source:  BioPlex,STRINGDB
TRIOBP
Tbio
Novelty:  0.04145641
p_int:  0.997340314
p_ni:  0.002656328
p_wrong:  0.000003357
Score:  0.194
Data Source:  BioPlex,STRINGDB
CST1
Tbio
Novelty:  0.02399609
p_int:  0.993202417
p_ni:  0.00073719
p_wrong:  0.006060392
Data Source:  BioPlex
DNM1
Tbio
Novelty:  0.00319082
Score:  0.984
Data Source:  STRINGDB
WASL
Tbio
Novelty:  0.0029314
Score:  0.975
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Clathrin-mediated endocytosis (R-HSA-8856828)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Clathrin-mediated endocytosis
Reactome
Membrane Trafficking
Reactome
Vesicle-mediated transport
Name
Explore in Pharos
Explore in Source
Clathrin-mediated endocytosis
Membrane Trafficking
Vesicle-mediated transport
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (29)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
9
4
12
95.2
appendicular lean mass
3
3
5
92.6
BMI-adjusted hip circumference
2
10
10
87
high density lipoprotein cholesterol measurement
1
1
1
83
low density lipoprotein cholesterol measurement
2
2
2
80.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
12
95.2
appendicular lean mass
5
92.6
BMI-adjusted hip circumference
10
87
high density lipoprotein cholesterol measurement
1
83
low density lipoprotein cholesterol measurement
2
80.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
protein kinase C and casein kinase substrate in neurons 1
718624
Mouse
MGI:1345181
23969
Rat
RGD:3247
29704
Dog
protein kinase C and casein kinase substrate in neurons 1
VGNC:44231
608087
Horse
protein kinase C and casein kinase substrate in neurons 1 [Source:HGNC Symbol;Acc:HGNC:8570]
Species
Name
OMA
EggNOG
Inparanoid
Macaque
protein kinase C and casein kinase substrate in neurons 1
Mouse
Rat
Dog
protein kinase C and casein kinase substrate in neurons 1
Horse
protein kinase C and casein kinase substrate in neurons 1 [Source:HGNC Symbol;Acc:HGNC:8570]
Publication Statistics
PubMed Score 69.61
PubMed score by year
PubTator Score 28.61
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title