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Tbio
PABPC3
Polyadenylate-binding protein 3

Protein Summary
Description
Binds the poly(A) tail of mRNA. May be involved in cytoplasmic regulatory processes of mRNA metabolism. Binds poly(A) with a slightly lower affinity as compared to PABPC1. Messenger RNA stability and translation initiation are extensively under the control of poly(A)-binding proteins (PABP). See PABPC1 (MIM 604679) for background information.[supplied by OMIM, Jul 2002]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000281589
  • ENSP00000281589
  • ENSG00000151846

Symbol
  • PABP3
  • PABPL3
  • PABP3
  • tPABP
  • PABPL3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.9
cell type or tissue
0.76
protein domain
0.58
cell line
0.54
protein complex
0.52


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.85   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 97   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.85   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 97   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (106)
ZC3H3
Tbio
Novelty:  0.26894046
p_int:  1
Score:  0.262
Data Source:  BioPlex,STRINGDB
GTF3C4
Tdark
Family:  Epigenetic
Novelty:  0.28198123
p_int:  0.999999614
p_ni:  2.6e-8
p_wrong:  3.6e-7
Data Source:  BioPlex
GALK2
Tbio
Family:  Kinase
Novelty:  0.06382824
p_int:  0.96068171
p_ni:  0.000002427
p_wrong:  0.039315863
Score:  0.252
Data Source:  BioPlex,STRINGDB
PAIP1
Tbio
Novelty:  0.05922084
Score:  0.961
Data Source:  STRINGDB
EIF4G1
Tbio
Novelty:  0.00170995
Score:  0.934
Data Source:  STRINGDB
ATXN2
Tbio
Novelty:  0.00373116
Score:  0.886
Data Source:  STRINGDB
CSTF3
Tbio
Novelty:  0.05260909
Score:  0.881
Data Source:  STRINGDB
EIF4G3
Tbio
Novelty:  0.03002723
Score:  0.874
Data Source:  STRINGDB
ATXN2L
Tbio
Novelty:  0.01996982
Score:  0.873
Data Source:  STRINGDB
GSPT2
Tchem
Family:  Enzyme
Novelty:  0.08140512
Score:  0.87
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
KEGG
RNA degradation
KEGG
mRNA surveillance pathway
KEGG
RNA transport
Name
Explore in Pharos
Explore in Source
RNA degradation
mRNA surveillance pathway
RNA transport
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (11)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Disease Associations (null)
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs
No orthologs found
Publication Statistics
PubMed Score 6.85
PubMed score by year
PubTator Score 1.58
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title