Tbio PAAF1 Proteasomal ATPase-associated factor 1

Protein Summary

Description

Inhibits proteasome 26S assembly and proteolytic activity by impairing the association of the 19S regulatory complex with the 20S core. In case of HIV-1 infection, recruited by viral Tat to the HIV-1 promoter, where it promotes the recruitment of 19S regulatory complex through dissociation of the proteasome 26S. This presumably promotes provirus transcription efficiency. Protects SUPT6H from proteasomal degradation. This gene encodes a WD repeat-containing protein involved in regulation of association of proteasome components. During HIV infection, the encoded protein is thought to promote provirus transcription through recruitment of the 19S regulatory complex. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jun 2012]

Uniprot Accession IDs

• Q9BRP4
• A6NDR5
• B4DPB0
• B7ZAS9
• Q4G165
• Q53HS9
• Q7Z500
• Q8TBU6
• Q9HAB6

Gene Name

• PAAF1

Ensembl ID

• ENST00000310571
• ENSP00000311665
• ENSG00000175575
• ENST00000376384
• ENSP00000365564
• ENST00000535604
• ENSP00000438789
• ENST00000536003
• ENSP00000438124
• ENST00000541951
• ENSP00000441333
• ENST00000544552
• ENSP00000441494

Symbol

• WDR71
• PAAF
• Rpn14
• WDR71

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.76
protein domain	0.73
cell line	0.64
kinase perturbation	0.6
tissue	0.59

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 46.67   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 110   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 46.67   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 110   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0