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Tbio
PA2G4
Proliferation-associated protein 2G4

Protein Summary
Description
May play a role in a ERBB3-regulated signal transduction pathway. Seems be involved in growth regulation. Acts a corepressor of the androgen receptor (AR) and is regulated by the ERBB3 ligand neuregulin-1/heregulin (HRG). Inhibits transcription of some E2F1-regulated promoters, probably by recruiting histone acetylase (HAT) activity. Binds RNA. Associates with 28S, 18S and 5.8S mature rRNAs, several rRNA precursors and probably U3 small nucleolar RNA. May be involved in regulation of intermediate and late steps of rRNA processing. May be involved in ribosome assembly. Mediates cap-independent translation of specific viral IRESs (internal ribosomal entry site) (By similarity). Regulates cell proliferation, differentiation, and survival. Isoform 1 suppresses apoptosis whereas isoform 2 promotes cell differentiation (By similarity). This gene encodes an RNA-binding protein that is involved in growth regulation. This protein is present in pre-ribosomal ribonucleoprotein complexes and may b ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000303305
  • ENSP00000302886
  • ENSG00000170515

Symbol
  • EBP1
  • EBP1
  • HG4-1
  • p38-2G4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.97
drug perturbation
0.96
disease perturbation
0.95
transcription factor perturbation
0.94
transcription factor binding site profile
0.92


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 83.58   (req: < 5)
Gene RIFs: 42   (req: <= 3)
Antibodies: 396   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 83.58   (req: >= 5)
Gene RIFs: 42   (req: > 3)
Antibodies: 396   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (554)
TMED7
Tdark
Novelty:  0.31193294
p_int:  0.885305619
p_ni:  0.114694257
p_wrong:  1.24e-7
Score:  0.609
Data Source:  BioPlex,STRINGDB
CCT2
Tbio
Novelty:  0.01967139
Score:  0.986
Data Source:  STRINGDB
CCT8
Tbio
Novelty:  0.03168289
Score:  0.98
Data Source:  STRINGDB
RPL4
Tbio
Novelty:  0.00475169
Score:  0.976
Data Source:  STRINGDB
MRTO4
Tbio
Novelty:  0.06676322
Score:  0.96
Data Source:  STRINGDB
GTPBP4
Tchem
Novelty:  0.00062563
Score:  0.955
Data Source:  STRINGDB
RPF2
Tbio
Novelty:  0.04148504
Score:  0.95
Data Source:  STRINGDB
NIFK
Tbio
Novelty:  0.01221562
Score:  0.949
Data Source:  STRINGDB
ADA2
Tbio
Family:  Enzyme
Novelty:  0.01077582
Score:  0.948
Data Source:  STRINGDB
RPL5
Tbio
Novelty:  0.00663792
Score:  0.946
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Immune System (R-HSA-168256)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Neutrophil degranulation
Name
Explore in Pharos
Explore in Source
Immune System
Innate Immune System
Neutrophil degranulation
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (50)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
type 1 diabetes mellitus
6
5
1
1.3
98.8
asthma
9
7
2
1.1
98.2
3
3
0
1.3
97.6
body height
3
3
5
97.1
self reported educational attainment
7
5
5
3.4
94.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
type 1 diabetes mellitus
1
1.3
98.8
asthma
2
1.1
98.2
0
1.3
97.6
body height
5
97.1
self reported educational attainment
5
3.4
94.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:894684
18813
Rat
RGD:1302994
288778
Dog
proliferation-associated 2G4
474396
Cow
proliferation-associated 2G4
540272
Xenopus
proliferation-associated 2G4
XB-GENE-943133
493284
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
proliferation-associated 2G4
Cow
proliferation-associated 2G4
Xenopus
proliferation-associated 2G4
Publication Statistics
PubMed Score 83.58
PubMed score by year
PubTator Score 74.98
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title