Tchem CYCS Cytochrome c

Protein Classes

DTO Classes

Cytochrome C Oxidase Subunit Ndufa4 / Cytochrome C Oxidase Subunit 2 / Cytochrome C Oxidase Subunit 5A, Mitochondrial / Cytochrome C Oxidase Subunit 3 / Cytochrome C Oxidase Subunit 7A1, Mitochondrial / Cytochrome C Oxidase Subunit 8A, Mitochondrial / Putative Cytochrome C Oxidase Subunit 7A3, Mitochondrial / Cytochrome C Oxidase Subunit 6A2, Mitochondrial / Cytochrome C Oxidase Subunit 7C, Mitochondrial / Cytochrome C Oxidase Subunit 7A-related Protein, Mitochondrial / Cytochrome C Oxidase Subunit 5B, Mitochondrial / Cytochrome C Oxidase Subunit 7A2, Mitochondrial / Cytochrome C Oxidase Subunit 1 / Cytochrome C Oxidase Subunit 8C, Mitochondrial / Cytochrome C Oxidase Subunit 6A1, Mitochondrial / Cytochrome C-type Heme Lyase / Cytochrome C Oxidase Copper Chaperone

Protein Summary

Description

Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases. This gene encodes a small heme protein that functions as a central component of the electron transport chain in mitochondria. The encoded protein associates with the inner membrane of the mitochondrion where it accepts electrons from cytochrome b and transfers them to the cytochrome oxidase complex. This protein is also involved in initiation of apoptosis. Mutations in this gene are associated with autosomal dominant nonsyndromic thrombocytopenia. Numerous processed pseudogenes of this gene are found throughout the human genome.[provided by RefSeq, Jul 2010]

Uniprot Accession IDs

• P99999
• A4D166
• B2R4I1
• P00001
• Q6NUR2
• Q6NX69
• Q96BV4

Gene Name

• CYCS

Ensembl ID

• ENST00000305786
• ENSP00000307786
• ENSG00000172115
• ENST00000409409
• ENSP00000386270
• ENST00000409764
• ENSP00000387279

Symbol

• CYC
• CYC
• HCS
• THC4

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
chemical	1
transcription factor perturbation	1
co-expressed gene	0.95
histone modification site profile	0.89
interacting protein	0.85

Related Tools

Target Illumination GWAS Analytics (TIGA)

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GENEVA

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GlyGen

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5814.83   (req: < 5)

Gene RIFs: 49   (req: <= 3)

Antibodies: 1260   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5814.83   (req: >= 5)

Gene RIFs: 49   (req: > 3)

Antibodies: 1260   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Active Ligands (1)

Explore Active Ligands

1 – 1 of 1

5,10,15,20-Tetrakis(4-carboxyphenyl)porphyrin

CYCSTchem

Kd : 6.02

GWAS Traits (2)

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GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
BMI-adjusted waist circumference	EFO_0007789	1	1	1		2.5
body fat percentage	EFO_0007800	1	1	2		0.6

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GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
BMI-adjusted waist circumference	EFO_0007789	1		2.5
body fat percentage	EFO_0007800	2		0.6

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Orthologs (16)

1 – 5 of 16

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	cytochrome c, somatic	VGNC:14767	744779
Mouse	predicted gene 10053	MGI:3704493	672195
Rat	cytochrome c, somatic	RGD:2451	25309
Dog	cytochrome c, somatic	VGNC:50288	475258
Horse	cytochrome c, somatic	VGNC:50468	100053958

Species	Name	OMA	EggNOG	Inparanoid
Chimp	cytochrome c, somatic
Mouse	predicted gene 10053
Rat	cytochrome c, somatic
Dog	cytochrome c, somatic
Horse	cytochrome c, somatic

Protein Structure (10 Structures, 1 AlphaFold Model)

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Representation

  axes   backbone   ball+stick   cartoon   rocket   rope   spacefill

Color Scheme

  target   atomindex   bfactor   chainname   electrostatic   element   hydrophobicity   resname   sstruc

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P99999-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 10

PDB Structure Id	Ligand	Method	Resolution (Å)	Residues	Fraction of Total Protein	Pub Year	Title

PDB Structure Id	Fraction of Total Protein	Resolution	Pub Year

Pathways (113)

Reactome (27)

KEGG (25)

PathwayCommons (11)

WikiPathways (50)

Activation of caspases through apoptosome-mediated cleavage (R-HSA-111459)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Activation of caspases through apoptosome-mediated cleavage	6 targets	R-HSA-111459
Reactome	Apoptosis	177 targets	R-HSA-109581
Reactome	Apoptotic factor-mediated response	16 targets	R-HSA-111471
Reactome	Cellular responses to external stimuli	487 targets	R-HSA-8953897
Reactome	Cellular responses to stress	392 targets	R-HSA-2262752

Name	Explore in Pharos	Explore in Source
Activation of caspases through apoptosome-mediated cleavage	6 targets	R-HSA-111459
Apoptosis	177 targets	R-HSA-109581
Apoptotic factor-mediated response	16 targets	R-HSA-111471
Cellular responses to external stimuli	487 targets	R-HSA-8953897
Cellular responses to stress	392 targets	R-HSA-2262752

Gene Ontology Terms (18)

Functions (3)

Components (7)

Processes (8)

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1 – 3 of 3

GO Term	Evidence	Assigned by
electron transporter, transferring electrons from CoQH2-cytochrome c reductase complex and cytochrome c oxidase complex activity	Inferred from Direct Assay (IDA)	UniProtKB
heme binding	Traceable Author Statement (TAS)	UniProtKB
metal ion binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Protein-Protein Interactions (746)

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1 – 10 of 746

• See Interactions on String-DB

LRG1

Tbio

Novelty:  0.00445522

p_int:  0.998752099

p_ni:  0.001247901

Score:  0.862

Data Source:  BioPlex,STRINGDB

COX5B

Tbio

Family:  Enzyme

Novelty:  0.01729026

Score:  0.999

Data Source:  STRINGDB

CYC1

Tchem

Novelty:  0.01369865

Score:  0.999

Data Source:  STRINGDB

MT-CO1

Tchem

Family:  Enzyme

Novelty:  0.00008262

Score:  0.999

Data Source:  STRINGDB

UQCRFS1

Tbio

Novelty:  0.00341256

Score:  0.999

Data Source:  STRINGDB

CASP9

Tchem

Family:  Enzyme

Novelty:  0.00023687

Score:  0.998

Data Source:  Reactome,STRINGDB

UQCRB

Tbio

Novelty:  0.02933046

Score:  0.998

Data Source:  STRINGDB

COX4I1

Tbio

Family:  Enzyme

Novelty:  0.00208873

Score:  0.998

Data Source:  STRINGDB

APAF1

Tchem

Family:  Enzyme

Novelty:  0.00107622

Score:  0.998

Data Source:  Reactome,STRINGDB

MT-CYB

Tbio

Novelty:  0.00012093

Score:  0.998

Data Source:  STRINGDB

Publication Statistics

PubMed Score  5814.83

PubMed score by year

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PubTator Score  9999.25

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

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UniProt Keyword Find Similar Targets

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3D-structure
Acetylation
Apoptosis
Complete proteome
Direct protein sequencing
Disease mutation
Electron transport
Heme
Iron
Metal-binding

GWAS Trait Find Similar Targets

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BMI-adjusted waist circumference
body fat percentage

MGI Phenotype Find Similar Targets

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behavior/neurological phenotype
cardiovascular system phenotype
cellular phenotype
craniofacial phenotype
embryo phenotype
endocrine/exocrine gland phenotype
growth/size/body region phenotype
hematopoietic system phenotype
immune system phenotype
mortality/aging