Protein Classes
Protein Summary
Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases. This gene encodes a small heme protein that functions as a central component of the electron transport chain in mitochondria. The encoded protein associates with the inner membrane of the mitochondrion where it accepts electrons from cytochrome b and transfers them to the cytochrome oxidase complex. Th ...more
- ENST00000305786
- ENSP00000307786
- ENSG00000172115
- ENST00000409409
- ENSP00000386270
- ENST00000409764
- ENSP00000387279
- CYC
- CYC
- HCS
- THC4
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
chemical | 1 | ||
transcription factor perturbation | 1 | ||
co-expressed gene | 0.95 | ||
histone modification site profile | 0.89 | ||
interacting protein | 0.85 | ||
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 5034.51 (req: < 5)
Gene RIFs: 49 (req: <= 3)
Antibodies: 1260 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 5034.51 (req: >= 5)
Gene RIFs: 49 (req: > 3)
Antibodies: 1260 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 11
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 1
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Active Ligands (1)
1 – 1 of 1
Protein Data Bank (10)
1 – 5 of 10
PDB Structure Id | Ligand | Method | Resolution (Å) | M.W. (kDa) | Pub Year | Title |
|---|
PDB Structure Id | M.W. | Resolution | Pub Year |
|---|
Pathways (113)
Reactome (27)
KEGG (25)
PathwayCommons (11)
WikiPathways (50)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 27
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Activation of caspases through apoptosome-mediated cleavage | ||||
Reactome | Apoptosis | ||||
Reactome | Apoptotic factor-mediated response | ||||
Reactome | Cellular responses to external stimuli | ||||
Reactome | Cellular responses to stress | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Activation of caspases through apoptosome-mediated cleavage | ||||
Apoptosis | ||||
Apoptotic factor-mediated response | ||||
Cellular responses to external stimuli | ||||
Cellular responses to stress | ||||
Gene Ontology Terms (18)
Functions (3)
Components (7)
Processes (8)
Items per page:
10
1 – 3 of 3
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Traceable Author Statement (TAS) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Protein-Protein Interactions (746)
1 – 10 of 746
LRG1
Novelty: 0.00703305
p_int: 0.998752099
p_ni: 0.001247901
Score: 0.862
Data Source: BioPlex,STRINGDB
COX5B
Family: Enzyme
Novelty: 0.02465452
Score: 0.999
Data Source: STRINGDB
CYC1
Novelty: 0.01978836
Score: 0.999
Data Source: STRINGDB
MT-CO1
Family: Enzyme
Novelty: 0.00015408
Score: 0.999
Data Source: STRINGDB
UQCRFS1
Novelty: 0.00380742
Score: 0.999
Data Source: STRINGDB
CASP9
Family: Enzyme
Novelty: 0.00031573
Score: 0.998
Data Source: Reactome,STRINGDB
UQCRB
Novelty: 0.04413786
Score: 0.998
Data Source: STRINGDB
COX4I1
Family: Enzyme
Novelty: 0.00416656
Score: 0.998
Data Source: STRINGDB
APAF1
Family: Enzyme
Novelty: 0.00164778
Score: 0.998
Data Source: Reactome,STRINGDB
MT-CYB
Novelty: 0.00015981
Score: 0.998
Data Source: STRINGDB
Publication Statistics
PubMed Score 5034.51
PubMed score by year
PubTator Score 9999.25
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
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UniProt Keyword