Protein Summary
Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases. This gene encodes a small heme protein that functions as a central component of the electron transport chain in mitochondria. The encoded protein associates with the inner membrane of the mitochondrion where it accepts electrons from cytochrome b and transfers them to the cytochrome oxidase complex. Th ...more
- ENST00000305786
- ENSP00000307786
- ENSG00000172115
- ENST00000409409
- ENSP00000386270
- ENST00000409764
- ENSP00000387279
- CYC
- CYC
- HCS
- THC4
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
chemical | 1 | ||
transcription factor perturbation | 1 | ||
co-expressed gene | 0.95 | ||
histone modification site profile | 0.89 | ||
interacting protein | 0.85 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 5814.83 (req: < 5)
Gene RIFs: 49 (req: <= 3)
Antibodies: 1260 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 5814.83 (req: >= 5)
Gene RIFs: 49 (req: > 3)
Antibodies: 1260 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 11
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 1
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (1)
Protein-Protein Interactions (746)
LRG1
Novelty: 0.00445522
p_int: 0.998752099
p_ni: 0.001247901
Score: 0.862
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets (1)
Upstream (1)
1 – 1 of 1
Pathways (113)
Reactome (27)
KEGG (25)
PathwayCommons (11)
WikiPathways (50)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Activation of caspases through apoptosome-mediated cleavage | ||||
Reactome | Apoptosis | ||||
Reactome | Apoptotic factor-mediated response | ||||
Reactome | Cellular responses to external stimuli | ||||
Reactome | Cellular responses to stress | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Activation of caspases through apoptosome-mediated cleavage | ||||
Apoptosis | ||||
Apoptotic factor-mediated response | ||||
Cellular responses to external stimuli | ||||
Cellular responses to stress | ||||
Viral Interactions (0)
Gene Ontology Terms (18)
Functions (3)
Components (7)
Processes (8)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Traceable Author Statement (TAS) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations ()
GWAS Traits (2)
Items per page:
1 – 2 of 2
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
BMI-adjusted waist circumference | 1 | 1 | 1 | 2.5 | |||||
body fat percentage | 1 | 1 | 2 | 0.6 | |||||
Items per page:
1 – 2 of 2
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
BMI-adjusted waist circumference | 1 | 2.5 | |||||
body fat percentage | 2 | 0.6 | |||||
Find similar targets by:
IDG Resources
Orthologs (16)
1 – 5 of 16
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | cytochrome c, somatic | VGNC:14767 | 744779 | |||||
Mouse | MGI:3704493 | 672195 | ||||||
Rat | RGD:2451 | 25309 | ||||||
Dog | cytochrome c, somatic | VGNC:50288 | 475258 | |||||
Horse | cytochrome c, somatic | VGNC:50468 | 100053958 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | cytochrome c, somatic | |||||
Mouse | ||||||
Rat | ||||||
Dog | cytochrome c, somatic | |||||
Horse | cytochrome c, somatic | |||||
Publication Statistics
PubMed Score 5814.83
PubMed score by year
PubTator Score 9999.25
PubTator score by year
Related Publications
Text Mined References (112)
GeneRif Annotations (49)
Items per page:
0 of 0
PMID | Year | Title |
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