Tchem CYCS Cytochrome c

Protein Summary

Description

Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases. This gene encodes a small heme protein that functions as a central component of the electron transport chain in mitochondria. The encoded protein associates with the inner membrane of the mitochondrion where it accepts electrons from cytochrome b and transfers them to the cytochrome oxidase complex. This protein is also involved in initiation of apoptosis. Mutations in this gene are associated with autosomal dominant nonsyndromic thrombocytopenia. Numerous processed pseudogenes of this gene are found throughout the human genome.[provided by RefSeq, Jul 2010]

Uniprot Accession IDs

• P99999
• A4D166
• B2R4I1
• P00001
• Q6NUR2
• Q6NX69
• Q96BV4

Gene Name

• CYCS

Ensembl ID

• ENST00000305786
• ENSP00000307786
• ENSG00000172115
• ENST00000409409
• ENSP00000386270
• ENST00000409764
• ENSP00000387279

Symbol

• CYC
• CYC
• HCS
• THC4

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
chemical	1
transcription factor perturbation	1
co-expressed gene	0.95
histone modification site profile	0.89
interacting protein	0.85

Protein Classes

DTO Classes

Cytochrome C Oxidase Subunit Ndufa4 / Cytochrome C Oxidase Subunit 2 / Cytochrome C Oxidase Subunit 5a, Mitochondrial / Cytochrome C Oxidase Subunit 3 / Cytochrome C Oxidase Subunit 7a1, Mitochondrial / Cytochrome C Oxidase Subunit 8a, Mitochondrial / Putative Cytochrome C Oxidase Subunit 7a3, Mitochondrial / Cytochrome C Oxidase Subunit 6a2, Mitochondrial / Cytochrome C Oxidase Subunit 7c, Mitochondrial / Cytochrome C Oxidase Subunit 7a-related Protein, Mitochondrial / Cytochrome C Oxidase Subunit 5b, Mitochondrial / Cytochrome C Oxidase Subunit 7a2, Mitochondrial / Cytochrome C Oxidase Subunit 1 / Cytochrome C Oxidase Subunit 8c, Mitochondrial / Cytochrome C Oxidase Subunit 6a1, Mitochondrial / Cytochrome C-type Heme Lyase / Cytochrome C Oxidase Copper Chaperone

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21003.58   (req: < 5)

Gene RIFs: 65   (req: <= 3)

Antibodies: 1260   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21003.58   (req: >= 5)

Gene RIFs: 65   (req: > 3)

Antibodies: 1260   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0