Protein Classes
Protein Summary
Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases. This gene encodes a small heme protein that functions as a central component of the electron transport chain in mitochondria. The encoded protein associates with the inner membrane of the mitochondrion where it accepts electrons from cytochrome b and transfers them to the cytochrome oxidase complex. Th ...more
- ENST00000305786
- ENSP00000307786
- ENSG00000172115
- ENST00000409409
- ENSP00000386270
- ENST00000409764
- ENSP00000387279
- CYC
- CYC
- HCS
- THC4
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
chemical | 1 | ||
transcription factor perturbation | 1 | ||
co-expressed gene | 0.95 | ||
histone modification site profile | 0.89 | ||
interacting protein | 0.85 | ||
Related Tools
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ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 5756.47 (req: < 5)
Gene RIFs: 49 (req: <= 3)
Antibodies: 1260 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 5756.47 (req: >= 5)
Gene RIFs: 49 (req: > 3)
Antibodies: 1260 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 11
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 1
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Active Ligands (1)
1 – 1 of 1
Orthologs (16)
1 – 5 of 16
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | cytochrome c, somatic | VGNC:14767 | 744779 | |||||
Mouse | MGI:3704493 | 672195 | ||||||
Rat | RGD:2451 | 25309 | ||||||
Dog | cytochrome c, somatic | VGNC:50288 | 475258 | |||||
Horse | cytochrome c, somatic | VGNC:50468 | 100053958 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | cytochrome c, somatic | |||||
Mouse | ||||||
Rat | ||||||
Dog | cytochrome c, somatic | |||||
Horse | cytochrome c, somatic | |||||
Protein Structure (10 Structures, 1 AlphaFold Model)
Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB
1 – 5 of 10
PDB Structure Id | Ligand | Method | Resolution (Å) | Residues | Fraction of Total Protein | Pub Year | Title |
|---|
PDB Structure Id | Fraction of Total Protein | Resolution | Pub Year |
|---|
Pathways (113)
Reactome (27)
KEGG (25)
PathwayCommons (11)
WikiPathways (50)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 27
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Activation of caspases through apoptosome-mediated cleavage | ||||
Reactome | Apoptosis | ||||
Reactome | Apoptotic factor-mediated response | ||||
Reactome | Cellular responses to external stimuli | ||||
Reactome | Cellular responses to stress | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Activation of caspases through apoptosome-mediated cleavage | ||||
Apoptosis | ||||
Apoptotic factor-mediated response | ||||
Cellular responses to external stimuli | ||||
Cellular responses to stress | ||||
Gene Ontology Terms (18)
Functions (3)
Components (7)
Processes (8)
Items per page:
10
1 – 3 of 3
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Traceable Author Statement (TAS) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Protein-Protein Interactions (746)
1 – 10 of 746
LRG1
Novelty: 0.00445522
p_int: 0.998752099
p_ni: 0.001247901
Score: 0.862
Data Source: BioPlex,STRINGDB
COX5B
Family: Enzyme
Novelty: 0.01729026
Score: 0.999
Data Source: STRINGDB
CYC1
Novelty: 0.01369865
Score: 0.999
Data Source: STRINGDB
MT-CO1
Family: Enzyme
Novelty: 0.00008262
Score: 0.999
Data Source: STRINGDB
UQCRFS1
Novelty: 0.00341256
Score: 0.999
Data Source: STRINGDB
CASP9
Family: Enzyme
Novelty: 0.00023687
Score: 0.998
Data Source: Reactome,STRINGDB
UQCRB
Novelty: 0.02933046
Score: 0.998
Data Source: STRINGDB
COX4I1
Family: Enzyme
Novelty: 0.00208873
Score: 0.998
Data Source: STRINGDB
APAF1
Family: Enzyme
Novelty: 0.00107622
Score: 0.998
Data Source: Reactome,STRINGDB
MT-CYB
Novelty: 0.00012093
Score: 0.998
Data Source: STRINGDB
Publication Statistics
PubMed Score 5756.47
PubMed score by year
PubTator Score 9999.25
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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UniProt Keyword