FOXO4
Forkhead box protein O4
Protein Summary
Transcription factor involved in the regulation of the insulin signaling pathway. Binds to insulin-response elements (IREs) and can activate transcription of IGFBP1. Down-regulates expression of HIF1A and suppresses hypoxia-induced transcriptional activation of HIF1A-modulated genes. Also involved in negative regulation of the cell cycle. Involved in increased proteasome activity in embryonic stem cells (ESCs) by activating expression of PSMD11 in ESCs, leading to enhanced assembly of the 26S proteasome, followed by higher proteasome activity. This gene encodes a member of the O class of winged helix/forkhead transcription factor family. Proteins encoded by this class are regulated by factors involved in growth and differentiation indicating they play a role in these processes. A translocation involving this gene on chromosome X and the homolog of the Drosophila trithorax gene, encoding a DNA binding protein, located on chromosome 11 is associated with leukemia. Multiple transcript var ...more
- ENST00000341558
- ENSP00000342209
- ENSG00000184481
- ENST00000374259
- ENSP00000363377
- AFX
- AFX1
- MLLT7
- AFX
- AFX1
- MLLT7
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological process | 0.9 | ||
hub protein | 0.88 | ||
histone modification site profile | 0.78 | ||
biological term | 0.77 | ||
kinase | 0.68 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 174.14 (req: < 5)
Gene RIFs: 74 (req: <= 3)
Antibodies: 891 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 174.14 (req: >= 5)
Gene RIFs: 74 (req: > 3)
Antibodies: 891 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 30
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (111)
Nearest Tclin Targets (5)
Upstream (3)
Downstream (2)
1 – 3 of 3
Pathways (44)
Reactome (21)
KEGG (2)
PathwayCommons (14)
WikiPathways (7)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | AKT phosphorylates targets in the nucleus | ||||
Reactome | Constitutive Signaling by AKT1 E17K in Cancer | ||||
Reactome | Deubiquitination | ||||
Reactome | Disease | ||||
Reactome | Diseases of signal transduction | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
AKT phosphorylates targets in the nucleus | ||||
Constitutive Signaling by AKT1 E17K in Cancer | ||||
Deubiquitination | ||||
Disease | ||||
Diseases of signal transduction | ||||
Viral Interactions (0)
Gene Ontology Terms (35)
Functions (10)
Components (5)
Processes (20)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | ParkinsonsUK-UCL | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | NTNU_SB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | IntAct | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Sequence Alignment (ISA) | NTNU_SB | |||
Inferred by Curator (IC) | NTNU_SB | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Disease Associations ()
GWAS Traits (4)
Items per page:
1 – 4 of 4
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
reticulocyte measurement | 3 | 2 | 3 | 94.6 | |||||
reticulocyte count | 2 | 1 | 2 | 86.6 | |||||
testosterone measurement | 1 | 1 | 1 | 12 | |||||
2 | 1 | 0 | 1 | 10.8 | |||||
Items per page:
1 – 4 of 4
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
reticulocyte measurement | 3 | 94.6 | |||||
reticulocyte count | 2 | 86.6 | |||||
testosterone measurement | 1 | 12 | |||||
0 | 1 | 10.8 | |||||
Find similar targets by:
IDG Resources
Orthologs (12)
1 – 5 of 12
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | forkhead box O4 | VGNC:1385 | 473659 | |||||
Macaque | forkhead box O4 | 698055 | ||||||
Mouse | MGI:1891915 | 54601 | ||||||
Rat | RGD:1561201 | 302415 | ||||||
Dog | forkhead box O4 | VGNC:40964 | 100855644 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | forkhead box O4 | |||||
Macaque | forkhead box O4 | |||||
Mouse | ||||||
Rat | ||||||
Dog | forkhead box O4 | |||||
Publication Statistics
PubMed Score 174.14
PubMed score by year
PubTator Score 83.09
PubTator score by year
Related Publications
Text Mined References (100)
GeneRif Annotations (74)
Items per page:
0 of 0
PMID | Year | Title |
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