Tbio EFNB1 Ephrin-B1

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Membrane-bound Signaling Molecule / Ephrin-b1

DTO Classes

Protein / Signaling / Membrane-bound Signaling Molecule / Ephrin-b1

Protein Summary

Description

Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development (PubMed:8070404, PubMed:7973638). Binding to Eph receptors residing on adjacent cells leads to contact-dependent bidirectional signaling into neighboring cells (PubMed:8070404, PubMed:7973638). Shows high affinity for the receptor tyrosine kinase EPHB1/ELK (PubMed:8070404, PubMed:7973638). Can also bind EPHB2 and EPHB3 (PubMed:8070404). Binds to, and induces collapse of, commissural axons/growth cones in vitro (By similarity). May play a role in constraining the orientation of longitudinally projecting axons (By similarity). The protein encoded by this gene is a type I membrane protein and a ligand of Eph-related receptor tyrosine kinases. It may play a role in cell adhesion and function in the development or maintenance of the nervous system. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P98172
• D3DVU0

Gene Name

• EFNB1

Ensembl ID

• ENST00000204961
• ENSP00000204961
• ENSG00000090776

Symbol

• EFL3
• EPLG2
• LERK2
• CFND
• CFNS
• EFB1
• EFL3
• EPLG2
• Elk-L
• LERK2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
PubMedID	0.85
kinase perturbation	0.76
cell type or tissue	0.71
disease	0.65
disease perturbation	0.62

Related Tools

GENEVA

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GlyGen

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 216.76   (req: < 5)

Gene RIFs: 49   (req: <= 3)

Antibodies: 517   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 216.76   (req: >= 5)

Gene RIFs: 49   (req: > 3)

Antibodies: 517   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Orthologs (9)

1 – 5 of 9

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Macaque	ephrin B1		694149
Mouse	ephrin B1	MGI:102708	13641
Rat	ephrin B1	RGD:2540	25186
Dog	ephrin B1	VGNC:40228	607410
Horse	ephrin B1 [Source:HGNC Symbol;Acc:HGNC:3226]

Species	Name	OMA	EggNOG	Inparanoid
Macaque	ephrin B1
Mouse	ephrin B1
Rat	ephrin B1
Dog	ephrin B1
Horse	ephrin B1 [Source:HGNC Symbol;Acc:HGNC:3226]

Protein Structure (0 Structures, 1 AlphaFold Model)

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Representation

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Color Scheme

  target   atomindex   bfactor   chainname   electrostatic   element   hydrophobicity   resname   sstruc

AF-P98172-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (78)

Reactome (5)

KEGG (1)

PathwayCommons (4)

WikiPathways (68)

Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Find Similar Targets

Items per page:

5

1 – 5 of 5

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Axon guidance	533 targets	R-HSA-422475
Reactome	Developmental Biology	1055 targets	R-HSA-1266738
Reactome	EPH-Ephrin signaling	92 targets	R-HSA-2682334
Reactome	EPH-ephrin mediated repulsion of cells	49 targets	R-HSA-3928665
Reactome	Ephrin signaling	19 targets	R-HSA-3928664

Name	Explore in Pharos	Explore in Source
Axon guidance	533 targets	R-HSA-422475
Developmental Biology	1055 targets	R-HSA-1266738
EPH-Ephrin signaling	92 targets	R-HSA-2682334
EPH-ephrin mediated repulsion of cells	49 targets	R-HSA-3928665
Ephrin signaling	19 targets	R-HSA-3928664

Gene Ontology Terms (17)

Functions (2)

Components (7)

Processes (8)

Find Similar Targets

Items per page:

10

1 – 2 of 2

GO Term	Evidence	Assigned by
protein tyrosine kinase activity	Inferred from Experiment (EXP)	Reactome
ephrin receptor binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central

Protein-Protein Interactions (210)

Explore Interacting Targets

1 – 10 of 210

• See Interactions on String-DB

EFNB2

Tbio

Novelty:  0.00255095

p_int:  0.999999671

p_ni:  4.2e-8

p_wrong:  2.88e-7

Score:  0.929

Data Source:  BioPlex,Reactome,STRINGDB

RGS3

Tbio

Novelty:  0.01749541

p_int:  0.999385774

p_ni:  0.000614164

p_wrong:  6.2e-8

Score:  0.962

Data Source:  BioPlex,STRINGDB

PLAC9

Tdark

Novelty:  0.23764669

p_int:  0.997881668

p_ni:  0.002118329

p_wrong:  3e-9

Data Source:  BioPlex

ATP1B3

Tclin

Family:  Transporter

Novelty:  0.06773518

p_int:  0.996284722

p_ni:  0.003715277

p_wrong:  1e-9

Data Source:  BioPlex

HLA-DQA1

Tbio

Novelty:  0.00077488

p_int:  0.992083573

p_ni:  0.007916426

p_wrong:  1e-9

Data Source:  BioPlex

DNM2

Tchem

Novelty:  0.00265965

p_int:  0.975365374

p_ni:  0.024626092

p_wrong:  0.000008534

Score:  0.16

Data Source:  BioPlex,STRINGDB

PICK1

Tbio

Novelty:  0.0058265

p_int:  0.96889733

p_ni:  0.031102383

p_wrong:  2.87e-7

Score:  0.542

Data Source:  BioPlex,STRINGDB

CTLA4

Tclin

Novelty:  0.00012781

p_int:  0.956219374

p_ni:  0.043772021

p_wrong:  0.000008604

Data Source:  BioPlex

PCDH12

Tbio

Novelty:  0.06268895

p_int:  0.955815241

p_ni:  0.044184758

p_wrong:  1e-9

Score:  0.16

Data Source:  BioPlex,STRINGDB

SLC39A4

Tbio

Family:  Transporter

Novelty:  0.00742159

p_int:  0.95244205

p_ni:  0.047557901

p_wrong:  4.9e-8

Data Source:  BioPlex

Publication Statistics

PubMed Score  216.76

PubMed score by year

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PubTator Score  124.51

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

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UniProt Keyword Find Similar Targets

No Header	No Header
Cell membrane
Complete proteome
Craniosynostosis
Developmental protein
Differentiation
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Disease mutation
Disulfide bond
Glycoprotein
Membrane

MGI Phenotype Find Similar Targets

No Header	No Header
cellular phenotype
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integument phenotype
limbs/digits/tail phenotype
mortality/aging