Protein Summary
Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development (PubMed:8070404, PubMed:7973638). Binding to Eph receptors residing on adjacent cells leads to contact-dependent bidirectional signaling into neighboring cells (PubMed:8070404, PubMed:7973638). Shows high affinity for the receptor tyrosine kinase EPHB1/ELK (PubMed:8070404, PubMed:7973638). Can also bind EPHB2 and EPHB3 (PubMed:8070404). Binds to, and induces collapse of, commissural axons/growth cones in vitro (By similarity). May play a role in constraining the orientation of longitudinally projecting axons (By similarity). The protein encoded by this gene is a type I membrane protein and a ligand of Eph-related receptor tyrosine kinases. It may play a role in cell adhesion and function in the development or maintenance of the nervous system. [provided by RefSeq, Jul 2008]
- ENST00000204961
- ENSP00000204961
- ENSG00000090776
- EFL3
- EPLG2
- LERK2
- CFND
- CFNS
- EFB1
- EFL3
- EPLG2
- Elk-L
- LERK2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
PubMedID | 0.85 | ||
kinase perturbation | 0.76 | ||
cell type or tissue | 0.71 | ||
disease | 0.65 | ||
disease perturbation | 0.62 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 216.76 (req: < 5)
Gene RIFs: 49 (req: <= 3)
Antibodies: 517 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 216.76 (req: >= 5)
Gene RIFs: 49 (req: > 3)
Antibodies: 517 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 10
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (210)
EFNB2
Novelty: 0.00255095
p_int: 0.999999671
p_ni: 4.2e-8
p_wrong: 2.88e-7
Score: 0.929
Data Source: BioPlex,Reactome,STRINGDB
RGS3
Novelty: 0.01749541
p_int: 0.999385774
p_ni: 0.000614164
p_wrong: 6.2e-8
Score: 0.962
Data Source: BioPlex,STRINGDB
PLAC9
Novelty: 0.23764669
p_int: 0.997881668
p_ni: 0.002118329
p_wrong: 3e-9
Data Source: BioPlex
ATP1B3
Family: Transporter
Novelty: 0.06773518
p_int: 0.996284722
p_ni: 0.003715277
p_wrong: 1e-9
Data Source: BioPlex
HLA-DQA1
Novelty: 0.00077488
p_int: 0.992083573
p_ni: 0.007916426
p_wrong: 1e-9
Data Source: BioPlex
DNM2
Novelty: 0.00265965
p_int: 0.975365374
p_ni: 0.024626092
p_wrong: 0.000008534
Score: 0.16
Data Source: BioPlex,STRINGDB
PICK1
Novelty: 0.0058265
p_int: 0.96889733
p_ni: 0.031102383
p_wrong: 2.87e-7
Score: 0.542
Data Source: BioPlex,STRINGDB
CTLA4
Novelty: 0.00012781
p_int: 0.956219374
p_ni: 0.043772021
p_wrong: 0.000008604
Data Source: BioPlex
PCDH12
Novelty: 0.06268895
p_int: 0.955815241
p_ni: 0.044184758
p_wrong: 1e-9
Score: 0.16
Data Source: BioPlex,STRINGDB
SLC39A4
Family: Transporter
Novelty: 0.00742159
p_int: 0.95244205
p_ni: 0.047557901
p_wrong: 4.9e-8
Data Source: BioPlex
Nearest Tclin Targets
Pathways (78)
Reactome (5)
KEGG (1)
PathwayCommons (4)
WikiPathways (68)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Axon guidance | ||||
Reactome | Developmental Biology | ||||
Reactome | EPH-Ephrin signaling | ||||
Reactome | EPH-ephrin mediated repulsion of cells | ||||
Reactome | Ephrin signaling | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Axon guidance | ||||
Developmental Biology | ||||
EPH-Ephrin signaling | ||||
EPH-ephrin mediated repulsion of cells | ||||
Ephrin signaling | ||||
Viral Interactions (0)
Gene Ontology Terms (17)
Functions (2)
Components (7)
Processes (8)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Experiment (EXP) | Reactome | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Disease Associations ()
GWAS Traits (0)
Find similar targets by:
IDG Resources
Orthologs (9)
1 – 5 of 9
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Macaque | ephrin B1 | 694149 | ||||||
Mouse | MGI:102708 | 13641 | ||||||
Rat | RGD:2540 | 25186 | ||||||
Dog | ephrin B1 | VGNC:40228 | 607410 | |||||
Horse | ephrin B1 [Source:HGNC Symbol;Acc:HGNC:3226] | |||||||
Publication Statistics
PubMed Score 216.76
PubMed score by year
PubTator Score 124.51
PubTator score by year
Related Publications
Text Mined References (80)
GeneRif Annotations (49)
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