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Tchem
XIAP
E3 ubiquitin-protein ligase XIAP

Protein Summary
Description
Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, copper homeostasis, mitogenic kinase signaling, cell proliferation, as well as cell invasion and metastasis. Acts as a direct caspase inhibitor. Directly bind to the active site pocket of CASP3 and CASP7 and obstructs substrate entry. Inactivates CASP9 by keeping it in a monomeric, inactive state. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and the target proteins for its E3 ubiquitin-protein ligase activity include: RIPK1, CASP3, CASP7, CASP8, CASP9, MAP3K2/MEKK2, DIABLO/SMAC, AIFM1, CCS and BIRC5/survivin. Ubiquitinion of CCS leads to enhancement of its chaperone activity toward its physiologic target, SOD1, rather than proteasomal degradation. Ubiquitinion of MAP3K2/MEKK2 and AIFM1 does not lead to proteasomal degradation. Plays a role in copper homeostasis by ubiquitinationg COMMD1 and promoting its proteasomal degradation. Can ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000355640
  • ENSP00000347858
  • ENSG00000101966
  • ENST00000371199
  • ENSP00000360242
  • ENST00000434753
  • ENSP00000395230

Symbol
  • API3
  • BIRC4
  • IAP3
  • API3
  • ILP1
  • MIHA
  • XLP2
  • BIRC4
  • IAP-3
  • hIAP3
  • hIAP-3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
chemical
1
biological process
0.91
microRNA
0.85
cell type or tissue
0.83
molecular function
0.79


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1761.37   (req: < 5)
Gene RIFs: 389   (req: <= 3)
Antibodies: 652   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1761.37   (req: >= 5)
Gene RIFs: 389   (req: > 3)
Antibodies: 652   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 912
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (289)
KLHL2
Tbio
Novelty:  0.07279226
p_int:  0.999998693
p_ni:  0.000001303
p_wrong:  4e-9
Score:  0.157
Data Source:  BioPlex,STRINGDB
DIABLO
Tbio
Novelty:  0.0007851
p_int:  0.999997123
p_ni:  0.000002544
p_wrong:  3.33e-7
Score:  0.998
Data Source:  BioPlex,Reactome,STRINGDB
LRRN2
Tdark
Novelty:  0.22583761
p_int:  0.999995685
p_ni:  0.000004314
p_wrong:  1e-9
Score:  0.536
Data Source:  BioPlex,STRINGDB
BIRC8
Tchem
Novelty:  0.05142518
p_int:  0.999974832
p_ni:  0.000025168
Score:  0.771
Data Source:  BioPlex,STRINGDB
PRTN3
Tchem
Family:  Enzyme
Novelty:  0.00022728
p_int:  0.999956852
p_ni:  0.000043148
Data Source:  BioPlex
ADAMTS4
Tchem
Family:  Enzyme
Novelty:  0.00424194
p_int:  0.999923226
p_ni:  0.000076774
Score:  0.215
Data Source:  BioPlex,STRINGDB
OSTM1
Tbio
Novelty:  0.03033192
p_int:  0.999732791
p_ni:  0.000267175
p_wrong:  3.3e-8
Data Source:  BioPlex
CASP3
Tchem
Family:  Enzyme
Novelty:  0.00003555
p_int:  0.99956311
p_ni:  0.000436886
p_wrong:  4e-9
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
CLEC11A
Tbio
Novelty:  0.03060601
p_int:  0.998888642
p_ni:  0.001111345
p_wrong:  1.3e-8
Data Source:  BioPlex
PHB2
Tbio
Novelty:  0.00458856
p_int:  0.997392218
p_ni:  0.002607782
Score:  0.245
Data Source:  BioPlex,STRINGDB
Pathways (53)
Activation of caspases through apoptosome-mediated cleavage (R-HSA-111459)

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1 – 5 of 27
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of caspases through apoptosome-mediated cleavage
Reactome
Apoptosis
Reactome
Apoptotic factor-mediated response
Reactome
Cytochrome c-mediated apoptotic response
Reactome
Deactivation of the beta-catenin transactivating complex
Name
Explore in Pharos
Explore in Source
Activation of caspases through apoptosome-mediated cleavage
Apoptosis
Apoptotic factor-mediated response
Cytochrome c-mediated apoptotic response
Deactivation of the beta-catenin transactivating complex
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (23)
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Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Experiment (EXP)
Reactome
Inferred from Direct Assay (IDA)
ProtInc
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations ()
No disease associations found
GWAS Traits (0)
No GWAS traits found
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
X-linked inhibitor of apoptosis
VGNC:6437
473765
Mouse
MGI:107572
11798
Rat
RGD:620692
63879
Dog
X-linked inhibitor of apoptosis
442989
Horse
X-linked inhibitor of apoptosis
100060870
Species
Name
OMA
EggNOG
Inparanoid
Chimp
X-linked inhibitor of apoptosis
Mouse
Rat
Dog
X-linked inhibitor of apoptosis
Horse
X-linked inhibitor of apoptosis
Publication Statistics
PubMed Score 1761.37
PubMed score by year
PubTator Score 1105.39
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title