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Tbio
LRP2
Low-density lipoprotein receptor-related protein 2

Protein Summary
Description
Multiligand endocytic receptor (By similarity). Acts together with CUBN to mediate endocytosis of high-density lipoproteins (By similarity). Mediates receptor-mediated uptake of polybasic drugs such as aprotinin, aminoglycosides and polymyxin B (By similarity). In the kidney, mediates the tubular uptake and clearance of leptin (By similarity). Also mediates transport of leptin across the blood-brain barrier through endocytosis at the choroid plexus epithelium (By similarity). Endocytosis of leptin in neuronal cells is required for hypothalamic leptin signaling and leptin-mediated regulation of feeding and body weight (By similarity). Mediates endocytosis and subsequent lysosomal degradation of CST3 in kidney proximal tubule cells (By similarity). Mediates renal uptake of 25-hydroxyvitamin D3 in complex with the vitamin D3 transporter GC/DBP (By similarity). Mediates renal uptake of metallothionein-bound heavy metals (PubMed:15126248). Together with CUBN, mediates renal reabsorption of ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000263816
  • ENSP00000263816
  • ENSG00000081479
  • ENST00000649046
  • ENSP00000496870

Symbol
  • DBS
  • GP330
  • LRP-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
PubMedID
0.94
disease
0.7
microRNA
0.7
phenotype
0.67


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 709.86   (req: < 5)
Gene RIFs: 64   (req: <= 3)
Antibodies: 280   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 709.86   (req: >= 5)
Gene RIFs: 64   (req: > 3)
Antibodies: 280   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 33
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (15)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urate measurement
5
8
8
96.7
glomerular filtration rate
7
8
10
9.7
94
creatinine measurement
3
6
6
93.4
serum gamma-glutamyl transferase measurement
2
3
3
89.8
C-reactive protein measurement
2
2
2
79.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urate measurement
8
96.7
glomerular filtration rate
10
9.7
94
creatinine measurement
6
93.4
serum gamma-glutamyl transferase measurement
3
89.8
C-reactive protein measurement
2
79.6
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
LDL receptor related protein 2
VGNC:1990
459713
Macaque
LDL receptor related protein 2
705786
Mouse
MGI:95794
14725
Rat
RGD:68407
29216
Dog
LDL receptor related protein 2
VGNC:42775
478781
Species
Name
OMA
EggNOG
Inparanoid
Chimp
LDL receptor related protein 2
Macaque
LDL receptor related protein 2
Mouse
Rat
Dog
LDL receptor related protein 2
Protein Structure (1 Structure, 18 AlphaFold Models)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (24)
Cargo recognition for clathrin-mediated endocytosis (R-HSA-8856825)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 16
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cargo recognition for clathrin-mediated endocytosis
Reactome
Clathrin-mediated endocytosis
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Reactome
Membrane Trafficking
Name
Explore in Pharos
Explore in Source
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
G alpha (i) signalling events
GPCR downstream signalling
Membrane Trafficking
Gene Ontology Terms (50)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
ARUK-UCL
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (275)
1 – 10 of 275
ZFP41
Tdark
Family:  TF
Novelty:  3.33093006
p_int:  0.996496643
p_ni:  0.003503357
Data Source:  BioPlex
SNW1
Tbio
Novelty:  0.01423797
p_int:  0.990663904
p_ni:  0.009336096
Data Source:  BioPlex
ZNF408
Tbio
Family:  TF
Novelty:  0.10649477
p_int:  0.988507196
p_ni:  0.011492804
Data Source:  BioPlex
LRPAP1
Tbio
Novelty:  0.00214194
p_int:  0.984447189
p_ni:  0.015552811
Score:  0.978
Data Source:  BioPlex,STRINGDB
IL10
Tbio
Novelty:  0.00004352
p_int:  0.979830768
p_ni:  0.020169232
Data Source:  BioPlex
ZSCAN29
Tdark
Family:  TF
Novelty:  1.70466621
p_int:  0.976034089
p_ni:  0.023965911
Score:  0.201
Data Source:  BioPlex,STRINGDB
CCDC59
Tbio
Novelty:  0.05894885
p_int:  0.975085015
p_ni:  0.024914985
Data Source:  BioPlex
UTP14C
Tdark
Novelty:  0.22698737
p_int:  0.973117051
p_ni:  0.026882949
Data Source:  BioPlex
IL20
Tbio
Novelty:  0.78184288
p_int:  0.970296414
p_ni:  0.029703586
Data Source:  BioPlex
MAP7
Tbio
Novelty:  0.01976296
p_int:  0.967613748
p_ni:  0.032386252
Data Source:  BioPlex
Publication Statistics
PubMed Score  709.86

PubMed score by year
PubTator Score  259.71

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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