Protein Summary
Component of a heteromeric calcium-permeable ion channel formed by PKD1 and PKD2 that is activated by interaction between PKD1 and a Wnt family member, such as WNT3A and WNT9B (PubMed:27214281). Both PKD1 and PKD2 are required for channel activity (PubMed:27214281). Involved in renal tubulogenesis (PubMed:12482949). Involved in fluid-flow mechanosensation by the primary cilium in renal epithelium (By similarity). Acts as a regulator of cilium length, together with PKD2 (By similarity). The dynamic control of cilium length is essential in the regulation of mechanotransductive signaling (By similarity). The cilium length response creates a negative feedback loop whereby fluid shear-mediated deflection of the primary cilium, which decreases intracellular cAMP, leads to cilium shortening and thus decreases flow-induced signaling (By similarity). May be an ion-channel regulator. Involved in adhesive protein-protein and protein-carbohydrate interactions. This gene encodes a member of the pol ...more
- ENST00000262304
- ENSP00000262304
- ENSG00000008710
- ENST00000423118
- ENSP00000399501
- PBP
- PC1
- Pc-1
- TRPP1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological process | 1 | ||
protein domain | 1 | ||
cellular component | 0.97 | ||
molecular function | 0.84 | ||
virus perturbation | 0.76 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 333.48 (req: < 5)
Gene RIFs: 193 (req: <= 3)
Antibodies: 179 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 333.48 (req: >= 5)
Gene RIFs: 193 (req: > 3)
Antibodies: 179 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 49
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (108)
Nearest Tclin Targets
Pathways (7)
Reactome (4)
WikiPathways (3)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Cargo trafficking to the periciliary membrane | ||||
Reactome | Cilium Assembly | ||||
Reactome | Organelle biogenesis and maintenance | ||||
Reactome | VxPx cargo-targeting to cilium | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Cargo trafficking to the periciliary membrane | ||||
Cilium Assembly | ||||
Organelle biogenesis and maintenance | ||||
VxPx cargo-targeting to cilium | ||||
Viral Interactions (0)
Gene Ontology Terms (66)
Functions (6)
Components (17)
Processes (43)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Sequence or structural Similarity (ISS) | BHF-UCL | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations ()
GWAS Traits (43)
Items per page:
1 – 5 of 43
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
triglyceride measurement | 5 | 3 | 6 | 94.2 | |||||
omega-6 polyunsaturated fatty acid measurement | 2 | 2 | 3 | 94 | |||||
appendicular lean mass | 4 | 3 | 7 | 93.6 | |||||
blood metabolite measurement | 3 | 3 | 4 | 93.1 | |||||
serum gamma-glutamyl transferase measurement | 2 | 2 | 2 | 90.8 | |||||
Items per page:
1 – 5 of 43
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
triglyceride measurement | 6 | 94.2 | |||||
omega-6 polyunsaturated fatty acid measurement | 3 | 94 | |||||
appendicular lean mass | 7 | 93.6 | |||||
blood metabolite measurement | 4 | 93.1 | |||||
serum gamma-glutamyl transferase measurement | 2 | 90.8 | |||||
Find similar targets by:
IDG Resources
Orthologs (8)
1 – 5 of 8
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Mouse | MGI:97603 | 18763 | ||||||
Rat | RGD:3333 | 24650 | ||||||
Dog | polycystin 1, transient receptor potential channel interacting | VGNC:44597 | 606755 | |||||
Horse | polycystin 1, transient receptor potential channel interacting | VGNC:21487 | 100068126 | |||||
Cow | polycystin 1, transient receptor potential channel interacting | VGNC:32933 | 504986 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Mouse | ||||||
Rat | ||||||
Dog | polycystin 1, transient receptor potential channel interacting | |||||
Horse | polycystin 1, transient receptor potential channel interacting | |||||
Cow | polycystin 1, transient receptor potential channel interacting | |||||
Publication Statistics
PubMed Score 333.48
PubMed score by year
PubTator Score 1118.29
PubTator score by year
Related Publications
Text Mined References (255)
GeneRif Annotations (193)
Items per page:
0 of 0
PMID | Year | Title |
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