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Tbio
PKD1
Polycystin-1

Protein Summary
Description
Component of a heteromeric calcium-permeable ion channel formed by PKD1 and PKD2 that is activated by interaction between PKD1 and a Wnt family member, such as WNT3A and WNT9B (PubMed:27214281). Both PKD1 and PKD2 are required for channel activity (PubMed:27214281). Involved in renal tubulogenesis (PubMed:12482949). Involved in fluid-flow mechanosensation by the primary cilium in renal epithelium (By similarity). Acts as a regulator of cilium length, together with PKD2 (By similarity). The dynamic control of cilium length is essential in the regulation of mechanotransductive signaling (By similarity). The cilium length response creates a negative feedback loop whereby fluid shear-mediated deflection of the primary cilium, which decreases intracellular cAMP, leads to cilium shortening and thus decreases flow-induced signaling (By similarity). May be an ion-channel regulator. Involved in adhesive protein-protein and protein-carbohydrate interactions. This gene encodes a member of the pol ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262304
  • ENSP00000262304
  • ENSG00000008710
  • ENST00000423118
  • ENSP00000399501

Symbol
  • PBP
  • PC1
  • Pc-1
  • TRPP1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
protein domain
1
cellular component
0.97
molecular function
0.84
virus perturbation
0.76


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 333.48   (req: < 5)
Gene RIFs: 193   (req: <= 3)
Antibodies: 179   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 333.48   (req: >= 5)
Gene RIFs: 193   (req: > 3)
Antibodies: 179   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 49
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (108)
PKD2
Tchem
Family:  IC
Novelty:  0.00305329
Score:  0.968
Data Source:  STRINGDB
ARF4
Tbio
Family:  Enzyme
Novelty:  0.01166211
Score:  0.941
Data Source:  Reactome,STRINGDB
RHO
Tbio
Family:  GPCR
Novelty:  0.00012925
Score:  0.94
Data Source:  STRINGDB
RAB3IP
Tbio
Novelty:  0.04046982
Score:  0.937
Data Source:  Reactome,STRINGDB
RAB8A
Tbio
Family:  Enzyme
Novelty:  0.00486694
Score:  0.936
Data Source:  Reactome,STRINGDB
ASAP1
Tbio
Novelty:  0.00913771
Score:  0.935
Data Source:  Reactome,STRINGDB
CNGB1
Tbio
Family:  IC
Novelty:  0.01034916
Score:  0.934
Data Source:  STRINGDB
EXOC5
Tbio
Novelty:  0.02200205
Score:  0.921
Data Source:  STRINGDB
RAB11A
Tbio
Family:  Enzyme
Novelty:  0.00153551
Score:  0.921
Data Source:  Reactome,STRINGDB
RAB11FIP3
Tbio
Novelty:  0.07915085
Score:  0.917
Data Source:  Reactome,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
Cargo trafficking to the periciliary membrane (R-HSA-5620920)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cargo trafficking to the periciliary membrane
Reactome
Cilium Assembly
Reactome
Organelle biogenesis and maintenance
Reactome
VxPx cargo-targeting to cilium
Name
Explore in Pharos
Explore in Source
Cargo trafficking to the periciliary membrane
Cilium Assembly
Organelle biogenesis and maintenance
VxPx cargo-targeting to cilium
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (66)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations ()
No disease associations found
GWAS Traits (43)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
5
3
6
94.2
omega-6 polyunsaturated fatty acid measurement
2
2
3
94
appendicular lean mass
4
3
7
93.6
blood metabolite measurement
3
3
4
93.1
serum gamma-glutamyl transferase measurement
2
2
2
90.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
6
94.2
omega-6 polyunsaturated fatty acid measurement
3
94
appendicular lean mass
7
93.6
blood metabolite measurement
4
93.1
serum gamma-glutamyl transferase measurement
2
90.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:97603
18763
Rat
RGD:3333
24650
Dog
polycystin 1, transient receptor potential channel interacting
VGNC:44597
606755
Horse
polycystin 1, transient receptor potential channel interacting
VGNC:21487
100068126
Cow
polycystin 1, transient receptor potential channel interacting
VGNC:32933
504986
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
polycystin 1, transient receptor potential channel interacting
Horse
polycystin 1, transient receptor potential channel interacting
Cow
polycystin 1, transient receptor potential channel interacting
Publication Statistics
PubMed Score 333.48
PubMed score by year
PubTator Score 1118.29
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title