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Tbio
VLDLR
Very low-density lipoprotein receptor

Protein Summary
Description
Binds VLDL and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. Binding to Reelin induces tyrosine phosphorylation of Dab1 and modulation of Tau phosphorylation (By similarity). The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. This gene encodes a lipoprotein receptor that is a member of the LDLR family and plays important roles in VLDL-triglyceride metabolism and the reelin signaling pathway. Mutations in this gene cause VLDLR-associated cerebellar hypoplasia. Alternative splicing generates multiple transcript variants encoding distinct isoforms for this gene. [provided by RefSeq, Aug 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000382099
  • ENSP00000371531
  • ENSG00000147852
  • ENST00000382100
  • ENSP00000371532

Symbol
  • CAMRQ1
  • CARMQ1
  • CHRMQ1
  • VLDL-R
  • VLDLRCH
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.99
transcription factor perturbation
0.99
PubMedID
0.95
molecular function
0.93
gene perturbation
0.91


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 308.17   (req: < 5)
Gene RIFs: 58   (req: <= 3)
Antibodies: 448   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 308.17   (req: >= 5)
Gene RIFs: 58   (req: > 3)
Antibodies: 448   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 24
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (118)
LRPAP1
Tbio
Novelty:  0.00214194
p_int:  0.999999968
p_ni:  3.1e-8
p_wrong:  1e-9
Score:  0.962
Data Source:  BioPlex,STRINGDB
ANKRD36B
Tdark
Novelty:  2.44907149
p_int:  0.999999933
p_ni:  5.1e-8
p_wrong:  1.7e-8
Data Source:  BioPlex
SYT1
Tbio
Novelty:  0.00176103
p_int:  0.999999311
p_ni:  6.34e-7
p_wrong:  5.5e-8
Score:  0.256
Data Source:  BioPlex,STRINGDB
LRRC4C
Tbio
Novelty:  0.06534005
p_int:  0.999831726
p_ni:  0.000132693
p_wrong:  0.000035582
Score:  0.523
Data Source:  BioPlex,STRINGDB
ZNF408
Tbio
Family:  TF
Novelty:  0.10649477
p_int:  0.998777722
p_ni:  0.001129869
p_wrong:  0.000092409
Score:  0.164
Data Source:  BioPlex,STRINGDB
RELN
Tbio
Novelty:  0.005326
Score:  0.995
Data Source:  Reactome,STRINGDB
DAB1
Tbio
Novelty:  0.08538222
Score:  0.989
Data Source:  Reactome,STRINGDB
MYLIP
Tbio
Family:  Enzyme
Novelty:  0.00836935
Score:  0.978
Data Source:  Reactome,STRINGDB
PCSK9
Tclin
Family:  Enzyme
Novelty:  0.00030553
Score:  0.975
Data Source:  Reactome,STRINGDB
PAFAH1B3
Tbio
Family:  Enzyme
Novelty:  0.10517347
Score:  0.967
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (11)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Developmental Biology
Reactome
Plasma lipoprotein assembly, remodeling, and clearance
Reactome
Plasma lipoprotein clearance
Reactome
Reelin signalling pathway
Name
Explore in Pharos
Explore in Source
Axon guidance
Developmental Biology
Plasma lipoprotein assembly, remodeling, and clearance
Plasma lipoprotein clearance
Reelin signalling pathway
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (31)
Find Similar Targets
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations ()
No disease associations found
GWAS Traits (18)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
vascular endothelial growth factor measurement
3
5
5
98.2
hemoglobin measurement
3
3
3
92.3
hematocrit
3
2
3
89.5
neutrophil count
2
2
3
85
leukocyte count
1
2
2
83.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
vascular endothelial growth factor measurement
5
98.2
hemoglobin measurement
3
92.3
hematocrit
3
89.5
neutrophil count
3
85
leukocyte count
2
83.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
very low density lipoprotein receptor
VGNC:4901
464967
Macaque
very low density lipoprotein receptor
574284
Mouse
MGI:98935
22359
Rat
RGD:3963
25696
Dog
very low density lipoprotein receptor
VGNC:48269
476336
Species
Name
OMA
EggNOG
Inparanoid
Chimp
very low density lipoprotein receptor
Macaque
very low density lipoprotein receptor
Mouse
Rat
Dog
very low density lipoprotein receptor
Publication Statistics
PubMed Score 308.17
PubMed score by year
PubTator Score 212.72
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title