VLDLR
Very low-density lipoprotein receptor
Protein Summary
Binds VLDL and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. Binding to Reelin induces tyrosine phosphorylation of Dab1 and modulation of Tau phosphorylation (By similarity). The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. This gene encodes a lipoprotein receptor that is a member of the LDLR family and plays important roles in VLDL-triglyceride metabolism and the reelin signaling pathway. Mutations in this gene cause VLDLR-associated cerebellar hypoplasia. Alternative splicing generates multiple transcript variants encoding distinct isoforms for this gene. [provided by RefSeq, Aug 2009]
- ENST00000382099
- ENSP00000371531
- ENSG00000147852
- ENST00000382100
- ENSP00000371532
- CAMRQ1
- CARMQ1
- CHRMQ1
- VLDL-R
- VLDLRCH
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
protein domain | 0.99 | ||
transcription factor perturbation | 0.99 | ||
PubMedID | 0.95 | ||
molecular function | 0.93 | ||
gene perturbation | 0.91 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 338.42 (req: < 5)
Gene RIFs: 64 (req: <= 3)
Antibodies: 448 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 338.42 (req: >= 5)
Gene RIFs: 64 (req: > 3)
Antibodies: 448 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 24
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0