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Tbio
FBLN2
Fibulin-2

Protein Summary
Description
Its binding to fibronectin and some other ligands is calcium dependent. May act as an adapter that mediates the interaction between FBN1 and ELN (PubMed:17255108). This gene encodes an extracellular matrix protein, which belongs to the fibulin family. This protein binds various extracellular ligands and calcium. It may play a role during organ development, in particular, during the differentiation of heart, skeletal and neuronal structures. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000295760
  • ENSP00000295760
  • ENSG00000163520
  • ENST00000404922
  • ENSP00000384169
  • ENST00000492059
  • ENSP00000420042
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.97
gene perturbation
0.91
tissue sample
0.69
virus
0.66
disease perturbation
0.62


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 57.3   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 244   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 57.3   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 244   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (3)
Elastic fibre formation (R-HSA-1566948)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Elastic fibre formation
Reactome
Extracellular matrix organization
Reactome
Molecules associated with elastic fibres
Name
Explore in Pharos
Explore in Source
Elastic fibre formation
Extracellular matrix organization
Molecules associated with elastic fibres
Protein-Protein Interactions (90)
1 – 10 of 90
ZNF664
Tdark
Family: TF
Novelty: 0.33511491
p_int: 0.999997485
p_ni: 0.000002514
Data Source: BioPlex
EFEMP1
Tbio
Novelty: 0.00630752
p_int: 0.999996844
p_ni: 0.000003142
p_wrong: 1.3e-8
Score: 0.922
Data Source: BioPlex,STRINGDB
ZNF709
Tdark
Family: TF
Novelty: 5
p_int: 0.99996653
p_ni: 0.000018106
p_wrong: 0.000015363
Data Source: BioPlex
ZNF628
Tdark
Family: TF
Novelty: 0.18545455
p_int: 0.999946984
p_ni: 0.000032723
p_wrong: 0.000020293
Data Source: BioPlex
CXCL5
Tbio
Novelty: 0.00339983
p_int: 0.999931489
p_ni: 0.000068466
p_wrong: 4.5e-8
Data Source: BioPlex
ZNF627
Tdark
Family: TF
Novelty: 0.34482759
p_int: 0.99993122
p_ni: 0.000064042
p_wrong: 0.000004738
Data Source: BioPlex
ZNF77
Tbio
Family: TF
Novelty: 0.00325881
p_int: 0.99987679
p_ni: 0.000010046
p_wrong: 0.000113165
Data Source: BioPlex
ZNF101
Tdark
Family: TF
Novelty: 0.5
p_int: 0.999192785
p_ni: 0.000796659
p_wrong: 0.000010556
Data Source: BioPlex
ZNF358
Tdark
Family: TF
Novelty: 1.04347826
p_int: 0.999093786
p_ni: 0.000906111
p_wrong: 1.02e-7
Data Source: BioPlex
ZNF696
Tdark
Family: TF
Novelty: 11
p_int: 0.997623536
p_ni: 0.002376464
Data Source: BioPlex
Publication Statistics
PubMed Score  57.30

PubMed score by year
PubTator Score  46.77

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer