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Tbio
MUC5AC
Mucin-5AC

Protein Summary
Description
Gel-forming glycoprotein of gastric and respiratoy tract epithelia that protects the mucosa from infection and chemical damage by binding to inhaled microrganisms and particles that are subsequently removed by the mucocilary system.
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
0.98
gene perturbation
0.86
chemical
0.71
cell line
0.69
interacting protein
0.61


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1407.02   (req: < 5)
Gene RIFs: 267   (req: <= 3)
Antibodies: 912   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1407.02   (req: >= 5)
Gene RIFs: 267   (req: > 3)
Antibodies: 912   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (3)
1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (16)
C-type lectin receptors (CLRs) (R-HSA-5621481)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 15
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
C-type lectin receptors (CLRs)
Reactome
Dectin-2 family
Reactome
Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS)
Reactome
Defective GALNT12 causes colorectal cancer 1 (CRCS1)
Reactome
Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC)
Name
Explore in Pharos
Explore in Source
C-type lectin receptors (CLRs)
Dectin-2 family
Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS)
Defective GALNT12 causes colorectal cancer 1 (CRCS1)
Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC)
Gene Ontology Terms (10)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
UniProtKB
Protein-Protein Interactions (165)
1 – 10 of 165
HBM
Tdark
Novelty: 0.02658671
p_int: 0.999977616
p_ni: 6.65e-7
p_wrong: 0.000021719
Score: 0.26
Data Source: BioPlex,STRINGDB
MUC1
Tbio
Novelty: 0.00024203
Score: 0.989
Data Source: STRINGDB
MUC16
Tbio
Novelty: 0.00444587
Score: 0.979
Data Source: STRINGDB
MUC7
Tbio
Novelty: 0.00750654
Score: 0.978
Data Source: STRINGDB
GALNT14
Tbio
Family: Enzyme
Novelty: 0.04069117
Score: 0.972
Data Source: STRINGDB
MUC17
Tbio
Novelty: 0.03624836
Score: 0.97
Data Source: STRINGDB
MUC12
Tbio
Novelty: 0.04323645
Score: 0.969
Data Source: STRINGDB
MUC13
Tbio
Novelty: 0.01282861
Score: 0.968
Data Source: STRINGDB
MUC20
Tbio
Novelty: 0.04645313
Score: 0.966
Data Source: STRINGDB
MUC3A
Tbio
Novelty: 0.0576775
Score: 0.966
Data Source: STRINGDB
Publication Statistics
PubMed Score  1407.02

PubMed score by year
PubTator Score  1053.5

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
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