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Tbio
DAB2
Disabled homolog 2

Protein Classes
Protein Summary
Description
Adapter protein that functions as clathrin-associated sorting protein (CLASP) required for clathrin-mediated endocytosis of selected cargo proteins. Can bind and assemble clathrin, and binds simultaneously to phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) and cargos containing non-phosphorylated NPXY internalization motifs, such as the LDL receptor, to recruit them to clathrin-coated pits. Can function in clathrin-mediated endocytosis independently of the AP-2 complex. Involved in endocytosis of integrin beta-1; this function seems to redundant with the AP-2 complex and seems to require DAB2 binding to endocytosis accessory EH domain-containing proteins such as EPS15, EPS15L1 and ITSN1. Involved in endocytosis of cystic fibrosis transmembrane conductance regulator/CFTR. Involved in endocytosis of megalin/LRP2 lipoprotein receptor during embryonal development. Required for recycling of the TGF-beta receptor. Involved in CFTR trafficking to the late endosome. Involved in several r ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000320816
  • ENSP00000313391
  • ENSG00000153071
  • ENST00000339788
  • ENSP00000345508
  • ENST00000509337
  • ENSP00000426245
  • ENST00000545653
  • ENSP00000439919

Symbol
  • DOC2
  • DOC2
  • DOC-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
transcription factor perturbation
1
PubMedID
0.99
hub protein
0.92
molecular function
0.88


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 201.89   (req: < 5)
Gene RIFs: 72   (req: <= 3)
Antibodies: 286   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 201.89   (req: >= 5)
Gene RIFs: 72   (req: > 3)
Antibodies: 286   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 29
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
3
5
8
97.5
glomerular filtration rate
6
5
6
10.9
93.7
creatinine measurement
3
2
3
83.6
1
1
0
1.2
55.2
1
1
0
1.1
36.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
8
97.5
glomerular filtration rate
6
10.9
93.7
creatinine measurement
3
83.6
0
1.2
55.2
0
1.1
36.6
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
DAB2, clathrin adaptor protein
VGNC:9063
461905
Macaque
DAB2, clathrin adaptor protein
694349
Mouse
MGI:109175
13132
Rat
RGD:621007
79128
Dog
DAB2, clathrin adaptor protein
VGNC:39759
479353
Species
Name
OMA
EggNOG
Inparanoid
Chimp
DAB2, clathrin adaptor protein
Macaque
DAB2, clathrin adaptor protein
Mouse
Rat
Dog
DAB2, clathrin adaptor protein
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P98082-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (34)
Cargo recognition for clathrin-mediated endocytosis (R-HSA-8856825)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cargo recognition for clathrin-mediated endocytosis
Reactome
Clathrin-mediated endocytosis
Reactome
Formation of annular gap junctions
Reactome
Gap junction degradation
Reactome
Gap junction trafficking
Name
Explore in Pharos
Explore in Source
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
Formation of annular gap junctions
Gap junction degradation
Gap junction trafficking
Protein-Protein Interactions (197)
1 – 10 of 197
FCHO2
Tbio
Novelty: 0.12302279
p_int: 0.999999834
p_ni: 1.33e-7
p_wrong: 3.4e-8
Score: 0.993
Data Source: BioPlex,STRINGDB
SLC25A41
Tdark
Family: Transporter
Novelty: 1.04918395
p_int: 0.999994107
p_ni: 5.9e-8
p_wrong: 0.000005834
Score: 0.489
Data Source: BioPlex,STRINGDB
PIP
Tbio
Novelty: 0.00208509
p_int: 0.999982936
p_ni: 0.000013274
p_wrong: 0.00000379
Data Source: BioPlex
SERPINB4
Tbio
Novelty: 0.00522283
p_int: 0.942382135
p_ni: 0.057617864
p_wrong: 1e-9
Score: 0.175
Data Source: BioPlex,STRINGDB
EPS15
Tbio
Novelty: 0.00451447
Score: 0.988
Data Source: STRINGDB
LRP2
Tbio
Novelty: 0.00143258
Score: 0.986
Data Source: Reactome,STRINGDB
MYO6
Tbio
Novelty: 0.01073438
Score: 0.983
Data Source: Reactome,STRINGDB
LDLR
Tchem
Novelty: 0.06585434
Score: 0.978
Data Source: Reactome,STRINGDB
SMAD2
Tbio
Family: TF
Novelty: 0.00040166
Score: 0.971
Data Source: STRINGDB
PICALM
Tbio
Novelty: 0.00800832
Score: 0.97
Data Source: STRINGDB
Publication Statistics
PubMed Score  201.89

PubMed score by year
PubTator Score  115.75

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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