You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
SHC2
SHC-transforming protein 2

Protein Summary
Description
Signaling adapter that couples activated growth factor receptors to signaling pathway in neurons. Involved in the signal transduction pathways of neurotrophin-activated Trk receptors in cortical neurons (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000264554
  • ENSP00000264554
  • ENSG00000129946

Symbol
  • SCK
  • SHCB
  • SCK
  • SLI
  • SHCB
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.73
pathway
0.71
hub protein
0.67
histone modification site profile
0.64
tissue
0.53


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 207.5   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 138   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 207.5   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 138   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (82)
SHC1
Tchem
Novelty:  0.00083615
p_int:  0.999999983
p_wrong:  1.7e-8
Score:  0.938
Data Source:  BioPlex,STRINGDB
NTRK2
Tclin
Family:  Kinase
Novelty:  0.00054534
Score:  0.988
Data Source:  STRINGDB
GRB2
Tchem
Novelty:  0.00091605
Score:  0.986
Data Source:  Reactome,STRINGDB
NTRK1
Tclin
Family:  Kinase
Novelty:  0.00033453
Score:  0.985
Data Source:  Reactome,STRINGDB
KDR
Tclin
Family:  Kinase
Novelty:  0.00016219
Score:  0.973
Data Source:  Reactome,STRINGDB
FLT1
Tclin
Family:  Kinase
Novelty:  0.00039648
Score:  0.95
Data Source:  STRINGDB
NTRK3
Tclin
Family:  Kinase
Novelty:  0.00177321
Score:  0.948
Data Source:  STRINGDB
SOS1
Tchem
Novelty:  0.00285343
Score:  0.931
Data Source:  Reactome,STRINGDB
EGFR
Tclin
Family:  Kinase
Novelty:  0.00007274
Score:  0.929
Data Source:  STRINGDB
BDNF
Tchem
Novelty:  0.00006891
Score:  0.925
Data Source:  STRINGDB
Nearest Tclin Targets (28)
Explore Nearest Tclin Targets
Pathways (62)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 16
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
FLT3 Signaling
Reactome
Immune System
Reactome
MAPK family signaling cascades
Reactome
MAPK1/MAPK3 signaling
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
FLT3 Signaling
Immune System
MAPK family signaling cascades
MAPK1/MAPK3 signaling
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean reticulocyte volume
1
1
1
50.6
reticulocyte measurement
1
1
1
31.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean reticulocyte volume
1
50.6
reticulocyte measurement
1
31.4
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:106180
216148
Rat
RGD:1307137
314612
Cow
SHC adaptor protein 2 [Source:HGNC Symbol;Acc:HGNC:29869]
Chicken
SHC (Src homology 2 domain containing) transforming protein 2
CGNC:880
770341
Anole lizard
SHC adaptor protein 2
100553545
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Cow
SHC adaptor protein 2 [Source:HGNC Symbol;Acc:HGNC:29869]
Chicken
SHC (Src homology 2 domain containing) transforming protein 2
Anole lizard
SHC adaptor protein 2
Publication Statistics
PubMed Score 207.50
PubMed score by year
PubTator Score 308.42
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title