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Tbio
SHC2
SHC-transforming protein 2

Protein Classes
Protein Summary
Description
Signaling adapter that couples activated growth factor receptors to signaling pathway in neurons. Involved in the signal transduction pathways of neurotrophin-activated Trk receptors in cortical neurons (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000264554
  • ENSP00000264554
  • ENSG00000129946

Symbol
  • SCK
  • SHCB
  • SCK
  • SLI
  • SHCB
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.73
pathway
0.71
hub protein
0.67
histone modification site profile
0.64
tissue
0.53


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 202.31   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 138   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 202.31   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 138   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (62)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 16
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
FLT3 Signaling
Reactome
Immune System
Reactome
MAPK family signaling cascades
Reactome
MAPK1/MAPK3 signaling
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
FLT3 Signaling
Immune System
MAPK family signaling cascades
MAPK1/MAPK3 signaling
Protein-Protein Interactions (82)
1 – 10 of 82
SHC1
Tchem
Novelty: 0.00083615
p_int: 0.999999983
p_wrong: 1.7e-8
Score: 0.938
Data Source: BioPlex,STRINGDB
NTRK2
Tclin
Family: Kinase
Novelty: 0.00054534
Score: 0.988
Data Source: STRINGDB
GRB2
Tchem
Novelty: 0.00091605
Score: 0.986
Data Source: Reactome,STRINGDB
NTRK1
Tclin
Family: Kinase
Novelty: 0.00033453
Score: 0.985
Data Source: Reactome,STRINGDB
KDR
Tclin
Family: Kinase
Novelty: 0.00016219
Score: 0.973
Data Source: Reactome,STRINGDB
FLT1
Tclin
Family: Kinase
Novelty: 0.00039648
Score: 0.95
Data Source: STRINGDB
NTRK3
Tclin
Family: Kinase
Novelty: 0.00177321
Score: 0.948
Data Source: STRINGDB
SOS1
Tbio
Novelty: 0.00285343
Score: 0.931
Data Source: Reactome,STRINGDB
EGFR
Tclin
Family: Kinase
Novelty: 0.00007274
Score: 0.929
Data Source: STRINGDB
BDNF
Tbio
Novelty: 0.00006891
Score: 0.925
Data Source: STRINGDB
Publication Statistics
PubMed Score  202.31

PubMed score by year
PubTator Score  308.42

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer