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Tchem
TMPRSS15
Enteropeptidase

Protein Summary
Description
Responsible for initiating activation of pancreatic proteolytic proenzymes (trypsin, chymotrypsin and carboxypeptidase A). It catalyzes the conversion of trypsinogen to trypsin which in turn activates other proenzymes including chymotrypsinogen, procarboxypeptidases, and proelastases. This gene encodes an enzyme that converts the pancreatic proenzyme trypsinogen to trypsin, which activates other proenzymes including chymotrypsinogen and procarboxypeptidases. The precursor protein is cleaved into two chains that form a heterodimer linked by a disulfide bond. This protein is a member of the trypsin family of peptidases. Mutations in this gene cause enterokinase deficiency, a malabsorption disorder characterized by diarrhea and failure to thrive. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000284885
  • ENSP00000284885
  • ENSG00000154646

Symbol
  • ENTK
  • PRSS7
  • ENTK
  • PRSS7
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
gene perturbation
0.97
cell line
0.59
microRNA
0.53
cell type or tissue
0.46


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 786.37   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 202   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 786.37   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 202   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 255
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (255)
US8609715, A-71
Rendered image for US8609715, A-71
US9346821, A-6
Rendered image for US9346821, A-6
US8609715, A-59
Rendered image for US8609715, A-59
US8609715, B-21
Rendered image for US8609715, B-21
US8609715, B-20
Rendered image for US8609715, B-20
US8609715, B-49
Rendered image for US8609715, B-49
CHEMBL3672886
Rendered image for CHEMBL3672886
US8609715, B-25
Rendered image for US8609715, B-25
US9346821, B-14
Rendered image for US9346821, B-14
US8609715, A-67
Rendered image for US8609715, A-67
Protein-Protein Interactions (46)
SPINK1
Tbio
Family:  Enzyme
Novelty:  0.00074416
Score:  0.816
Data Source:  STRINGDB
AGRN
Tbio
Novelty:  0.00156441
Score:  0.76
Data Source:  STRINGDB
ABCB7
Tbio
Family:  Transporter
Novelty:  0.00985796
Score:  0.759
Data Source:  STRINGDB
NSF
Tbio
Family:  Enzyme
Novelty:  0.00173489
Score:  0.735
Data Source:  STRINGDB
SLC4A10
Tbio
Family:  Transporter
Novelty:  0.02669548
Score:  0.723
Data Source:  STRINGDB
SLC4A7
Tbio
Family:  Transporter
Novelty:  0.011156
Score:  0.723
Data Source:  STRINGDB
SLC4A8
Tbio
Family:  Transporter
Novelty:  0.01606111
Score:  0.723
Data Source:  STRINGDB
TXN
Tchem
Novelty:  0.00048949
Score:  0.673
Data Source:  STRINGDB
SSC4D
Tdark
Novelty:  0.78340524
Score:  0.653
Data Source:  STRINGDB
LIPC
Tchem
Family:  Enzyme
Novelty:  0.00219107
Score:  0.648
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
1
1
1
21.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
1
21.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
transmembrane serine protease 15
VGNC:3728
458478
Mouse
MGI:1197523
19146
Rat
RGD:1311046
288291
Dog
transmembrane serine protease 15
VGNC:47632
487700
Horse
transmembrane serine protease 15
VGNC:24340
100067591
Species
Name
OMA
EggNOG
Inparanoid
Chimp
transmembrane serine protease 15
Mouse
Rat
Dog
transmembrane serine protease 15
Horse
transmembrane serine protease 15
Publication Statistics
PubMed Score 786.37
PubMed score by year
PubTator Score 87.13
PubTator score by year
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Related Publications
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PMID
Year
Title