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Tdark
CCZ1B
Vacuolar fusion protein CCZ1 homolog B

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Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.27   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 40   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.27   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 40   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (14)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
IGF-1 measurement
1
1
1
68
hematocrit
3
2
3
67.1
hemoglobin measurement
3
1
3
61.4
neutrophil count
1
1
1
57.3
Myopia
1
1
0
8.8
29.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
IGF-1 measurement
1
68
hematocrit
3
67.1
hemoglobin measurement
3
61.4
neutrophil count
1
57.3
Myopia
0
8.8
29.9
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:2141070
231874
Dog
CCZ1 homolog, vacuolar protein trafficking and biogenesis associated
479750
Cow
CCZ1 homolog, vacuolar protein trafficking and biogenesis associated
511088
Chicken
CCZ1 homolog, vacuolar protein trafficking and biogenesis associated
CGNC:50256
416433
Zebrafish
ZDB-GENE-040426-698
393103
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Dog
CCZ1 homolog, vacuolar protein trafficking and biogenesis associated
Cow
CCZ1 homolog, vacuolar protein trafficking and biogenesis associated
Chicken
CCZ1 homolog, vacuolar protein trafficking and biogenesis associated
Zebrafish
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P86790-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (4)
Membrane Trafficking (R-HSA-199991)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Membrane Trafficking
Reactome
RAB GEFs exchange GTP for GDP on RABs
Reactome
Rab regulation of trafficking
Reactome
Vesicle-mediated transport
Name
Explore in Pharos
Explore in Source
Membrane Trafficking
RAB GEFs exchange GTP for GDP on RABs
Rab regulation of trafficking
Vesicle-mediated transport
Gene Ontology Terms (6)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
HPA
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (74)
1 – 10 of 74
LMO2
Tbio
Novelty:  0.0038279
p_int:  0.991743782
p_ni:  0.008256213
p_wrong:  5e-9
Data Source:  BioPlex
RPS14
Tbio
Novelty:  0.00576737
p_int:  0.986200368
p_ni:  0.013799632
Data Source:  BioPlex
KIF16B
Tbio
Novelty:  0.06703876
p_int:  0.968666263
p_ni:  0.031333737
Score:  0.43
Data Source:  BioPlex,STRINGDB
SP6
Tbio
Family:  TF
Novelty:  0.00201789
p_int:  0.923307052
p_ni:  0.076692948
Score:  0.243
Data Source:  BioPlex,STRINGDB
ETFRF1
Tdark
Novelty:  1.28847105
p_int:  0.800448
p_ni:  0.199552
Score:  0.188
Data Source:  BioPlex,STRINGDB
THBS3
Tbio
Novelty:  0.01915634
p_int:  0.777182206
p_ni:  0.222817783
p_wrong:  1e-8
Data Source:  BioPlex
SPINT2
Tbio
Family:  Enzyme
Novelty:  0.0046602
p_int:  0.763486571
p_ni:  0.236513429
Data Source:  BioPlex
KLHDC2
Tbio
Novelty:  0.01485159
p_int:  0.750408631
p_ni:  0.249591369
Score:  0.161
Data Source:  BioPlex,STRINGDB
MON1A
Tbio
Novelty:  0.04537045
Score:  0.996
Data Source:  STRINGDB
MON1B
Tbio
Novelty:  0.13486379
Score:  0.995
Data Source:  STRINGDB
Publication Statistics
PubMed Score  10.27

PubMed score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer