Tdark CCZ1B Vacuolar fusion protein CCZ1 homolog B

Protein Summary

Uniprot Accession IDs

• P86790
• A2RU45
• O95766
• Q9UG65
• Q9Y359

Gene Name

• CCZ1B

Ensembl ID

• ENST00000316731
• ENSP00000314544
• ENSG00000146574

Symbol

• C7orf28B
• CCZ1
• C7orf28A
• C7orf28B
• H_NH0577018.2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0
biological term	0
cell line	0
cell type or tissue	0
cellular component	0

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.27   (req: < 5)

Gene RIFs: 1   (req: <= 3)

Antibodies: 40   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.27   (req: >= 5)

Gene RIFs: 1   (req: > 3)

Antibodies: 40   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

GWAS Traits (14)

• Explore on Target Illumination GWAS Analytics (TIGA)

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1 – 5 of 14

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
IGF-1 measurement	EFO_0004627	1	1	1		68
hematocrit	EFO_0004348	3	2	3		67.1
hemoglobin measurement	EFO_0004509	3	1	3		61.4
neutrophil count	EFO_0004833	1	1	1		57.3
Myopia	HP_0000545	1	1	0	8.8	29.9

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 14

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
IGF-1 measurement	EFO_0004627	1		68
hematocrit	EFO_0004348	3		67.1
hemoglobin measurement	EFO_0004509	3		61.4
neutrophil count	EFO_0004833	1		57.3
Myopia	HP_0000545	0	8.8	29.9

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Orthologs (6)

1 – 5 of 6

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Mouse	CCZ1 vacuolar protein trafficking and biogenesis associated	MGI:2141070	231874
Dog	CCZ1 homolog, vacuolar protein trafficking and biogenesis associated		479750
Cow	CCZ1 homolog, vacuolar protein trafficking and biogenesis associated		511088
Chicken	CCZ1 homolog, vacuolar protein trafficking and biogenesis associated	CGNC:50256	416433
Zebrafish	CCZ1 homolog, vacuolar protein trafficking and biogenesis associated	ZDB-GENE-040426-698	393103

Species	Name	OMA	EggNOG	Inparanoid
Mouse	CCZ1 vacuolar protein trafficking and biogenesis associated
Dog	CCZ1 homolog, vacuolar protein trafficking and biogenesis associated
Cow	CCZ1 homolog, vacuolar protein trafficking and biogenesis associated
Chicken	CCZ1 homolog, vacuolar protein trafficking and biogenesis associated
Zebrafish	CCZ1 homolog, vacuolar protein trafficking and biogenesis associated

Protein Structure (0 Structures, 1 AlphaFold Model)

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Representation

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Color Scheme

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AF-P86790-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (4)

Reactome (4)

Membrane Trafficking (R-HSA-199991)

Click on a row in the table to change the structure displayed.

Find Similar Targets

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1 – 4 of 4

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Membrane Trafficking	612 targets	R-HSA-199991
Reactome	RAB GEFs exchange GTP for GDP on RABs	90 targets	R-HSA-8876198
Reactome	Rab regulation of trafficking	123 targets	R-HSA-9007101
Reactome	Vesicle-mediated transport	725 targets	R-HSA-5653656

Name	Explore in Pharos	Explore in Source
Membrane Trafficking	612 targets	R-HSA-199991
RAB GEFs exchange GTP for GDP on RABs	90 targets	R-HSA-8876198
Rab regulation of trafficking	123 targets	R-HSA-9007101
Vesicle-mediated transport	725 targets	R-HSA-5653656

Gene Ontology Terms (6)

Components (5)

Processes (1)

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Items per page:

10

1 – 5 of 5

GO Term	Evidence	Assigned by
aggresome	Inferred from Direct Assay (IDA)	HPA
cytosol	Inferred from Direct Assay (IDA)	HPA
intracellular membrane-bounded organelle	Inferred from Direct Assay (IDA)	HPA
lysosomal membrane	Inferred from Electronic Annotation (IEA)	UniProtKB-SubCell
Mon1-Ccz1 complex	Inferred from Electronic Annotation (IEA)	InterPro

Protein-Protein Interactions (74)

Explore Interacting Targets

1 – 10 of 74

• See Interactions on String-DB

LMO2

Tbio

Novelty:  0.0038279

p_int:  0.991743782

p_ni:  0.008256213

p_wrong:  5e-9

Data Source:  BioPlex

RPS14

Tbio

Novelty:  0.00576737

p_int:  0.986200368

p_ni:  0.013799632

Data Source:  BioPlex

KIF16B

Tbio

Novelty:  0.06703876

p_int:  0.968666263

p_ni:  0.031333737

Score:  0.43

Data Source:  BioPlex,STRINGDB

SP6

Tbio

Family:  TF

Novelty:  0.00201789

p_int:  0.923307052

p_ni:  0.076692948

Score:  0.243

Data Source:  BioPlex,STRINGDB

ETFRF1

Tdark

Novelty:  1.28847105

p_int:  0.800448

p_ni:  0.199552

Score:  0.188

Data Source:  BioPlex,STRINGDB

THBS3

Tbio

Novelty:  0.01915634

p_int:  0.777182206

p_ni:  0.222817783

p_wrong:  1e-8

Data Source:  BioPlex

SPINT2

Tbio

Family:  Enzyme

Novelty:  0.0046602

p_int:  0.763486571

p_ni:  0.236513429

Data Source:  BioPlex

KLHDC2

Tbio

Novelty:  0.01485159

p_int:  0.750408631

p_ni:  0.249591369

Score:  0.161

Data Source:  BioPlex,STRINGDB

MON1A

Tbio

Novelty:  0.04537045

Score:  0.996

Data Source:  STRINGDB

MON1B

Tbio

Novelty:  0.13486379

Score:  0.995

Data Source:  STRINGDB

Publication Statistics

PubMed Score  10.27

PubMed score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

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Acetylation
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GWAS Trait Find Similar Targets

No Header	No Header
age at onset
Alzheimer's disease
APOE carrier status
appendicular lean mass
fasting blood insulin measurement
hematocrit
hemoglobin measurement
IGF-1 measurement
mitochondrial heteroplasmy measurement
Myopia