Tbio H3F3A Histone H3.3

Protein Summary

Description

Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene contains introns and its mRNA is polyadenylated, unlike most histone genes. The protein encoded is a replication-independent member of the histone H3 family. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P84243
• P06351
• P33155
• Q5VV55
• Q5VV56
• Q66I33
• Q9V3W4

Gene Name

• H3F3A

Ensembl ID

• ENST00000254810
• ENSP00000254810
• ENSG00000132475
• ENST00000366813
• ENSP00000355778
• ENSG00000163041
• ENST00000366815
• ENSP00000355780
• ENST00000366816
• ENSP00000355781
• ENST00000586607
• ENSP00000466020
• ENST00000587560
• ENSP00000468714
• ENST00000589599
• ENSP00000465813

Symbol

• H3.3A
• H3F3
• H3F3
• H3.3A

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cellular component	0.98
kinase	0.98
transcription factor perturbation	0.98
transcription factor binding site profile	0.97
kinase perturbation	0.93

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 224.82   (req: < 5)

Gene RIFs: 81   (req: <= 3)

Antibodies: 501   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 224.82   (req: >= 5)

Gene RIFs: 81   (req: > 3)

Antibodies: 501   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 30

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0