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Tbio
SRSF3
Serine/arginine-rich splicing factor 3

Protein Summary
Description
Splicing factor that specifically promotes exon-inclusion during alternative splicing (PubMed:26876937). Interaction with YTHDC1, a RNA-binding protein that recognizes and binds N6-methyladenosine (m6A)-containing RNAs, promotes recruitment of SRSF3 to its mRNA-binding elements adjacent to m6A sites, leading to exon-inclusion during alternative splicing (PubMed:26876937). Also functions as export adapter involved in mRNA nuclear export (PubMed:11336712, PubMed:18364396, PubMed:28984244). Binds mRNA which is thought to be transferred to the NXF1-NXT1 heterodimer for export (TAP/NXF1 pathway); enhances NXF1-NXT1 RNA-binding activity (PubMed:11336712, PubMed:18364396). Involved in nuclear export of m6A-containing mRNAs via interaction with YTHDC1: interaction with YTHDC1 facilitates m6A-containing mRNA-binding to both SRSF3 and NXF1, promoting mRNA nuclear export (PubMed:28984244). RNA-binding is semi-sequence specific (PubMed:17036044). The protein encoded by this gene is a member of the ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000373715
  • ENSP00000362820
  • ENSG00000112081
  • ENST00000477442
  • ENSP00000436036
  • ENST00000620941
  • ENSP00000482833

Symbol
  • SFRS3
  • SRP20
  • SFRS3
  • SRp20
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
transcription factor perturbation
0.99
transcription factor binding site profile
0.98
kinase perturbation
0.97
co-expressed gene
0.96


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 112.28   (req: < 5)
Gene RIFs: 56   (req: <= 3)
Antibodies: 262   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 112.28   (req: >= 5)
Gene RIFs: 56   (req: > 3)
Antibodies: 262   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cup-to-disc ratio measurement
1
1
1
5.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cup-to-disc ratio measurement
1
5.4
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
serine and arginine rich splicing factor 3
VGNC:52113
747921
Macaque
serine and arginine rich splicing factor 3
719123
Mouse
MGI:98285
20383
Rat
RGD:1309233
361814
Dog
serine and arginine rich splicing factor 3
VGNC:46819
403687
Species
Name
OMA
EggNOG
Inparanoid
Chimp
serine and arginine rich splicing factor 3
Macaque
serine and arginine rich splicing factor 3
Mouse
Rat
Dog
serine and arginine rich splicing factor 3
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P84103-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (13)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Metabolism of RNA
Reactome
Processing of Capped Intron-Containing Pre-mRNA
Reactome
RNA Polymerase II Transcription
Reactome
RNA Polymerase II Transcription Termination
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Metabolism of RNA
Processing of Capped Intron-Containing Pre-mRNA
RNA Polymerase II Transcription
RNA Polymerase II Transcription Termination
Gene Ontology Terms (12)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (363)
1 – 10 of 363
TRA2B
Tbio
Novelty: 0.0146833
Score: 0.999
Data Source: STRINGDB
SRSF1
Tbio
Novelty: 0.00074446
Score: 0.999
Data Source: STRINGDB
RBM8A
Tbio
Novelty: 0.00052175
Score: 0.999
Data Source: STRINGDB
HNRNPC
Tbio
Novelty: 0.00136097
Score: 0.998
Data Source: STRINGDB
HNRNPA1
Tchem
Novelty: 0.0020871
Score: 0.998
Data Source: STRINGDB
DDX39B
Tbio
Family: Enzyme
Novelty: 0.012548
Score: 0.998
Data Source: STRINGDB
HNRNPL
Tbio
Novelty: 0.01048413
Score: 0.998
Data Source: STRINGDB
HNRNPK
Tbio
Novelty: 0.00354731
Score: 0.998
Data Source: STRINGDB
HNRNPA2B1
Tbio
Novelty: 0.00404935
Score: 0.998
Data Source: STRINGDB
HNRNPM
Tbio
Novelty: 0.0125566
Score: 0.998
Data Source: STRINGDB
Publication Statistics
PubMed Score  112.28

PubMed score by year
PubTator Score  74.25

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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