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Tbio
RPL19
60S ribosomal protein L19

Protein Summary
Description
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L19E family of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000225430
  • ENSP00000225430
  • ENSG00000108298

Symbol
  • L19
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
interacting protein
1
kinase perturbation
1
small molecule perturbation
1
gene perturbation
0.99


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 97.44   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 183   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 97.44   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 183   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
2
3
2
13
92.1
mean corpuscular volume
1
1
1
81.2
reticulocyte measurement
2
1
2
68.6
creatinine measurement
1
2
2
50.5
1
1
0
1.1
40.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
2
13
92.1
mean corpuscular volume
1
81.2
reticulocyte measurement
2
68.6
creatinine measurement
2
50.5
0
1.1
40.7
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ribosomal protein L19
VGNC:9573
454625
Macaque
ribosomal protein L19
695987
Mouse
MGI:98020
19921
Rat
RGD:621183
81767
Dog
ribosomal protein L19
VGNC:45715
403682
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ribosomal protein L19
Macaque
ribosomal protein L19
Mouse
Rat
Dog
ribosomal protein L19
Protein Structure (7 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P84098-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 7
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (34)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 32
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Cap-dependent Translation Initiation
Reactome
Developmental Biology
Reactome
Disease
Reactome
Eukaryotic Translation Elongation
Name
Explore in Pharos
Explore in Source
Axon guidance
Cap-dependent Translation Initiation
Developmental Biology
Disease
Eukaryotic Translation Elongation
Protein-Protein Interactions (451)
1 – 10 of 451
H1FOO
Tbio
Novelty:  0.02189067
p_int:  0.839519404
p_ni:  0.160480596
Data Source:  BioPlex
E4F1
Tbio
Family:  TF
Novelty:  0.02192338
p_int:  0.837584795
p_ni:  0.162415205
Data Source:  BioPlex
ZCRB1
Tdark
Novelty:  0.37592387
p_int:  0.83547623
p_ni:  0.16452377
Data Source:  BioPlex
RPS8
Tbio
Novelty:  0.00976281
p_int:  0.822296909
p_ni:  0.177703091
Score:  0.999
Data Source:  BioPlex,STRINGDB
RPL28
Tbio
Novelty:  0.03136035
p_int:  0.804063771
p_ni:  0.195936229
Score:  0.999
Data Source:  BioPlex,STRINGDB
SART3
Tbio
Novelty:  0.02353492
p_int:  0.782817852
p_ni:  0.217182148
Data Source:  BioPlex
H2AFX
Tbio
Novelty:  0.00048694
p_int:  0.767998814
p_ni:  0.232001186
Score:  0.154
Data Source:  BioPlex,STRINGDB
RPS5
Tbio
Novelty:  0.00513677
Score:  0.999
Data Source:  STRINGDB
RPL4
Tbio
Novelty:  0.00475169
Score:  0.999
Data Source:  STRINGDB
RPS26
Tbio
Novelty:  0.0183394
Score:  0.999
Data Source:  STRINGDB
Publication Statistics
PubMed Score  97.44

PubMed score by year
PubTator Score  18.89

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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