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Tbio
RHOG
Rho-related GTP-binding protein RhoG

Protein Summary
Description
Required for the formation of membrane ruffles during macropinocytosis. Plays a role in cell migration and is required for the formation of cup-like structures during trans-endothelial migration of leukocytes. In case of Salmonella enterica infection, activated by SopB and ARHGEF26/SGEF, which induces cytoskeleton rearrangements and promotes bacterial entry. This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. The encoded protein facilitates translocation of a functional guanine nucleotide exchange factor (GEF) complex from the cytoplasm to the plasma membrane where ras-related C3 botulinum toxin substrate 1 is activated to promote lamellipodium formation and cell migration. Two related pseudogene have been identified on chromosomes ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000351018
  • ENSP00000339467
  • ENSG00000177105
  • ENST00000396978
  • ENSP00000380175
  • ENST00000396979
  • ENSP00000380176
  • ENST00000533217
  • ENSP00000436932

Symbol
  • ARHG
  • ARHG
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.91
interacting protein
0.84
transcription factor binding site profile
0.81
disease perturbation
0.74
biological process
0.69


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 234.36   (req: < 5)
Gene RIFs: 24   (req: <= 3)
Antibodies: 168   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 234.36   (req: >= 5)
Gene RIFs: 24   (req: > 3)
Antibodies: 168   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
3
2
3
92.2
basophil count
2
2
2
64
platelet crit
1
1
1
58.4
IGF-1 measurement
1
1
1
56
mean corpuscular volume
1
1
1
47.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
3
92.2
basophil count
2
64
platelet crit
1
58.4
IGF-1 measurement
1
56
mean corpuscular volume
1
47.7
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ras homolog family member G
VGNC:11673
748092
Macaque
ras homolog family member G
718113
Mouse
MGI:1928370
56212
Rat
RGD:621310
308875
Dog
ras homolog family member G
VGNC:45560
485217
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ras homolog family member G
Macaque
ras homolog family member G
Mouse
Rat
Dog
ras homolog family member G
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P84095-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (27)
Constitutive Signaling by Aberrant PI3K in Cancer (R-HSA-2219530)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 19
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Constitutive Signaling by Aberrant PI3K in Cancer
Reactome
Disease
Reactome
Diseases of signal transduction
Reactome
GPVI-mediated activation cascade
Reactome
Hemostasis
Name
Explore in Pharos
Explore in Source
Constitutive Signaling by Aberrant PI3K in Cancer
Disease
Diseases of signal transduction
GPVI-mediated activation cascade
Hemostasis
Protein-Protein Interactions (258)
1 – 10 of 258
NT5E
Tchem
Family:  Enzyme
Novelty:  0.00083237
p_int:  0.988711072
p_ni:  1.77e-7
p_wrong:  0.011288751
Score:  0.209
Data Source:  BioPlex,STRINGDB
DOCK1
Tbio
Novelty:  0.00867391
Score:  0.989
Data Source:  STRINGDB
ARHGDIA
Tchem
Novelty:  0.001991
Score:  0.989
Data Source:  STRINGDB
ELMO1
Tbio
Novelty:  0.01598587
Score:  0.988
Data Source:  STRINGDB
ARHGEF26
Tbio
Novelty:  0.09349583
Score:  0.981
Data Source:  STRINGDB
ELMO2
Tbio
Novelty:  0.04258272
Score:  0.981
Data Source:  STRINGDB
MCF2
Tbio
Novelty:  0.00345951
Score:  0.981
Data Source:  STRINGDB
VAV2
Tbio
Novelty:  0.01062502
Score:  0.98
Data Source:  Reactome,STRINGDB
VAV1
Tchem
Novelty:  0.00180518
Score:  0.979
Data Source:  Reactome,STRINGDB
VAV3
Tbio
Novelty:  0.010944
Score:  0.978
Data Source:  Reactome,STRINGDB
Publication Statistics
PubMed Score  234.36

PubMed score by year
PubTator Score  79.69

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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