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Tbio
ARF5
ADP-ribosylation factor 5

Protein Summary
Description
GTP-binding protein involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus. (Microbial infection) Functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. This gene is a member of the human ADP-ribosylation factor (ARF) gene family. These genes encode small guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin and play a role in vesicular trafficking and as activators of phospholipase D. The gene products include 6 ARF proteins and 11 ARF-like proteins and constitute 1 family of the RAS superfamily. The ARF proteins are categorized as class I (ARF1, ARF2,and ARF3), class II (ARF4 and ARF5) and class III (ARF6). The members of each class share a common gene organization. [provided by RefSeq, Dec 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000000233
  • ENSP00000000233
  • ENSG00000004059
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.98
molecular function
0.91
disease perturbation
0.83
cell type or tissue
0.74
cellular component
0.73


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.48   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 225   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.48   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 225   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (14)
Asparagine N-linked glycosylation (R-HSA-446203)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Asparagine N-linked glycosylation
Reactome
COPI-dependent Golgi-to-ER retrograde traffic
Reactome
COPI-mediated anterograde transport
Reactome
ER to Golgi Anterograde Transport
Reactome
Golgi-to-ER retrograde transport
Name
Explore in Pharos
Explore in Source
Asparagine N-linked glycosylation
COPI-dependent Golgi-to-ER retrograde traffic
COPI-mediated anterograde transport
ER to Golgi Anterograde Transport
Golgi-to-ER retrograde transport
Gene Ontology Terms (11)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (223)
1 – 10 of 223
ARF1
Tchem
Family: Enzyme
Novelty: 0.00272021
p_int: 0.999999999
p_wrong: 1e-9
Score: 0.986
Data Source: BioPlex,STRINGDB
ARF3
Tbio
Family: Enzyme
Novelty: 0.00403923
p_int: 0.999934482
p_ni: 0.000065518
Score: 0.908
Data Source: BioPlex,STRINGDB
EPDR1
Tbio
Novelty: 0.05021948
p_int: 0.99989002
p_ni: 0.000109953
p_wrong: 2.6e-8
Data Source: BioPlex
ARF4
Tbio
Family: Enzyme
Novelty: 0.02098758
p_int: 0.998150026
p_ni: 0.001849974
Score: 0.902
Data Source: BioPlex,STRINGDB
ALPI
Tbio
Family: Enzyme
Novelty: 0.00247141
p_int: 0.972322958
p_ni: 0.027677011
p_wrong: 3.1e-8
Score: 0.175
Data Source: BioPlex,STRINGDB
IL20RA
Tbio
Novelty: 0.03295383
p_int: 0.968617162
p_ni: 0.031382831
p_wrong: 7e-9
Data Source: BioPlex
PLPPR2
Tdark
Family: Enzyme
Novelty: 1.875
p_int: 0.939789189
p_ni: 0.060210749
p_wrong: 6.2e-8
Score: 0.158
Data Source: BioPlex,STRINGDB
KLK8
Tchem
Family: Enzyme
Novelty: 0.00379475
p_int: 0.936938901
p_ni: 0.063061099
Score: 0.15
Data Source: BioPlex,STRINGDB
NT5E
Tchem
Family: Enzyme
Novelty: 0.00121213
p_int: 0.925788731
p_ni: 0.074211269
Data Source: BioPlex
PCYOX1
Tbio
Family: Enzyme
Novelty: 0.24200876
p_int: 0.923607777
p_ni: 0.076392223
Data Source: BioPlex
Publication Statistics
PubMed Score  24.48

PubMed score by year
PubTator Score  41.8

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer