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Tchem
ARF1
ADP-ribosylation factor 1

Protein Summary
Description
GTP-binding protein involved in protein trafficking among different compartments. Modulates vesicle budding and uncoating within the Golgi complex. Deactivation induces the redistribution of the entire Golgi complex to the endoplasmic reticulum, suggesting a crucial role in protein trafficking. In its GTP-bound form, its triggers the association with coat proteins with the Golgi membrane. The hydrolysis of ARF1-bound GTP, which is mediated by ARFGAPs proteins, is required for dissociation of coat proteins from Golgi membranes and vesicles. The GTP-bound form interacts with PICK1 to limit PICK1-mediated inhibition of Arp2/3 complex activity; the function is linked to AMPA receptor (AMPAR) trafficking, regulation of synaptic plasicity of excitatory synapses and spine shrinkage during long-term depression (LTD). (Microbial infection) Functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. ADP-ribosylation factor 1 (ARF1) is a member of the h ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000272102
  • ENSP00000272102
  • ENSG00000143761
  • ENST00000540651
  • ENSP00000442980
  • ENST00000541182
  • ENSP00000440005

Symbol
  • PVNH8
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
kinase perturbation
1
disease perturbation
0.98
molecular function
0.97
virus perturbation
0.97


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 402.83   (req: < 5)
Gene RIFs: 88   (req: <= 3)
Antibodies: 513   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 402.83   (req: >= 5)
Gene RIFs: 88   (req: > 3)
Antibodies: 513   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 36
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Active Ligands (1)
1 – 1 of 1
CHEMBL259181
chemical structure image
Protein Data Bank (11)
1 – 5 of 11
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (51)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 36
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Asparagine N-linked glycosylation
Reactome
COPI-dependent Golgi-to-ER retrograde traffic
Reactome
COPI-mediated anterograde transport
Reactome
Cytokine Signaling in Immune system
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Asparagine N-linked glycosylation
COPI-dependent Golgi-to-ER retrograde traffic
COPI-mediated anterograde transport
Cytokine Signaling in Immune system
Gene Ontology Terms (55)
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
CAFA
Inferred from Mutant Phenotype (IMP)
CAFA
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (410)
1 – 10 of 410
ARF5
Tbio
Family: Enzyme
Novelty: 0.03428337
p_int: 0.999999999
p_wrong: 1e-9
Score: 0.986
Data Source: BioPlex,STRINGDB
CYTH2
Tbio
Novelty: 0.01792419
Score: 0.999
Data Source: Reactome,STRINGDB
AP1B1
Tbio
Novelty: 0.03313791
Score: 0.997
Data Source: STRINGDB
CYTH1
Tbio
Novelty: 0.00791403
Score: 0.996
Data Source: Reactome,STRINGDB
ARFGAP1
Tbio
Family: Enzyme
Novelty: 0.04267604
Score: 0.996
Data Source: STRINGDB
AP1S3
Tbio
Novelty: 0.19881657
Score: 0.994
Data Source: STRINGDB
AP3B1
Tbio
Novelty: 0.05716867
Score: 0.991
Data Source: STRINGDB
AP1G1
Tbio
Novelty: 0.01774073
Score: 0.991
Data Source: STRINGDB
ARFGAP3
Tbio
Family: Enzyme
Novelty: 0.04125459
Score: 0.99
Data Source: STRINGDB
RAB5C
Tbio
Family: Enzyme
Novelty: 0.05493596
Score: 0.99
Data Source: STRINGDB
Publication Statistics
PubMed Score  402.83

PubMed score by year
PubTator Score  390.19

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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