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Tbio
HPCA
Neuron-specific calcium-binding protein hippocalcin

Protein Summary
Description
Calcium-binding protein that may play a role in the regulation of voltage-dependent calcium channels (PubMed:28398555). May also play a role in cyclic-nucleotide-mediated signaling through the regulation of adenylate and guanylate cyclases (By similarity). The protein encoded by this gene is a member of neuron-specific calcium-binding proteins family found in the retina and brain. This protein is associated with the plasma membrane. It has similarities to proteins located in the photoreceptor cells that regulate photosignal transduction in a calcium-sensitive manner. This protein displays recoverin activity and a calcium-dependent inhibition of rhodopsin kinase. It is identical to the rat and mouse hippocalcin proteins and thought to play an important role in neurons of the central nervous system in a number of species. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000373467
  • ENSP00000362566
  • ENSG00000121905

Symbol
  • BDR2
  • BDR2
  • DYT2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor
0.66
cell type or tissue
0.65
protein domain
0.58
PubMedID
0.55
transcription factor binding site profile
0.53


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 80.14   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 91   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 80.14   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 91   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
hippocalcin
VGNC:1264
746988
Macaque
hippocalcin
710249
Mouse
MGI:1336200
15444
Rat
RGD:620060
29177
Dog
hippocalcin
VGNC:52136
611787
Species
Name
OMA
EggNOG
Inparanoid
Chimp
hippocalcin
Macaque
hippocalcin
Mouse
Rat
Dog
hippocalcin
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P84074-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Gene Ontology Terms (30)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (156)
1 – 10 of 156
NUFIP1
Tbio
Novelty: 0.11726869
p_int: 0.999999371
p_ni: 5.69e-7
p_wrong: 6e-8
Data Source: BioPlex
HAX1
Tbio
Novelty: 0.00749205
p_int: 0.999995701
p_ni: 0.000002298
p_wrong: 0.000002001
Data Source: BioPlex
DGUOK
Tbio
Family: Kinase
Novelty: 0.00897987
p_int: 0.999980359
p_ni: 0.00001964
p_wrong: 1e-9
Data Source: BioPlex
DNAAF2
Tbio
Novelty: 0.01254416
p_int: 0.999867716
p_ni: 7.47e-7
p_wrong: 0.000131537
Data Source: BioPlex
GRK1
Tchem
Family: Kinase
Novelty: 0.00598725
Score: 0.863
Data Source: STRINGDB
NAIP
Tbio
Novelty: 0.00400896
Score: 0.794
Data Source: STRINGDB
KCND3
Tclin
Family: IC
Novelty: 0.00328276
Score: 0.786
Data Source: STRINGDB
KCNC1
Tclin
Family: IC
Novelty: 0.00252943
Score: 0.785
Data Source: STRINGDB
ATP5F1B
Tbio
Family: Enzyme
Novelty: 0.01053177
Score: 0.734
Data Source: STRINGDB
TUBB4A
Tclin
Novelty: 0.00045092
Score: 0.715
Data Source: STRINGDB
Publication Statistics
PubMed Score  80.14

PubMed score by year
PubTator Score  23.25

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer