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Tbio
SMAD3
Mothers against decapentaplegic homolog 3

Protein Summary
Description
Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD3/SMAD4 complex, activates transcription. Also can form a SMAD3/SMAD4/JUN/FOS complex at the AP-1/SMAD site to regulate TGF-beta-mediated transcription. Has an inhibitory effect on wound healing probably by modulating both growth and migration of primary keratinocytes and by altering the TGF-mediated chemotaxis of monocytes. This effect on wound healing appears to be hormone-sensitive. Regulator of chondrogenesis and osteogenesis and inhibits early healing of bone fractures. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator. The protein encoded by this gene belongs to the SMAD, a family of ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000327367
  • ENSP00000332973
  • ENSG00000166949
  • ENST00000439724
  • ENSP00000401133
  • ENST00000537194
  • ENSP00000445348
  • ENST00000540846
  • ENSP00000437757

Symbol
  • MADH3
  • LDS3
  • LDS1C
  • MADH3
  • JV15-2
  • HSPC193
  • HsT17436
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
hub protein
1
molecular function
1
biological term
0.99
phosphatase
0.95


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2075.45   (req: < 5)
Gene RIFs: 462   (req: <= 3)
Antibodies: 2043   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2075.45   (req: >= 5)
Gene RIFs: 462   (req: > 3)
Antibodies: 2043   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 112
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (43)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
14
11
1
1.1
99.5
4
3
0
1.1
98.4
Eczema
2
2
0
1.1
97.8
heel bone mineral density
3
4
6
97.2
7
4
3
1.1
94.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1.1
99.5
0
1.1
98.4
Eczema
0
1.1
97.8
heel bone mineral density
6
97.2
3
1.1
94.3
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
SMAD family member 3
VGNC:1877
748161
Macaque
SMAD family member 3
711355
Mouse
MGI:1201674
17127
Rat
RGD:3032
25631
Pig
SMAD family member 3
397260
Species
Name
OMA
EggNOG
Inparanoid
Chimp
SMAD family member 3
Macaque
SMAD family member 3
Mouse
Rat
Pig
SMAD family member 3
Protein Structure (10 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P84022-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 10
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (110)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 42
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Deubiquitination
Reactome
Developmental Biology
Reactome
Disease
Reactome
Diseases of signal transduction
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Deubiquitination
Developmental Biology
Disease
Diseases of signal transduction
Gene Ontology Terms (123)
Items per page:
10
1 – 10 of 32
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Protein-Protein Interactions (480)
1 – 10 of 480
SMAD2
Tbio
Family: TF
Novelty: 0.00040166
p_int: 1
p_wrong: 1e-9
Score: 0.995
Data Source: BioPlex,Reactome,STRINGDB
SMAD9
Tbio
Family: TF
Novelty: 0.00285887
p_int: 0.999999982
p_wrong: 1.8e-8
Score: 0.957
Data Source: BioPlex,STRINGDB
ZFYVE9
Tbio
Novelty: 0.00565862
p_int: 0.99999986
p_ni: 9.1e-8
p_wrong: 4.8e-8
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
LDLRAD4
Tbio
Novelty: 0.04881486
p_int: 0.9999935
p_ni: 8.57e-7
p_wrong: 0.000005643
Score: 0.445
Data Source: BioPlex,STRINGDB
HINT3
Tdark
Novelty: 1.14285714
p_int: 0.999894529
p_ni: 0.000091942
p_wrong: 0.000013529
Data Source: BioPlex
LEMD3
Tbio
Novelty: 0.00579701
p_int: 0.999538185
p_ni: 0.000461815
Score: 0.819
Data Source: BioPlex,STRINGDB
EVA1B
Tdark
Novelty: 2.1380272
p_int: 0.999385771
p_ni: 0.000575441
p_wrong: 0.000038787
Data Source: BioPlex
LACRT
Tbio
Novelty: 0.03333799
p_int: 0.991817054
p_ni: 0.008182946
Score: 0.181
Data Source: BioPlex,STRINGDB
FURIN
Tchem
Family: Enzyme
Novelty: 0.00055079
p_int: 0.800143452
p_ni: 0.000388329
p_wrong: 0.19946822
Score: 0.333
Data Source: BioPlex,STRINGDB
NEDD4L
Tbio
Family: Enzyme
Novelty: 0.00250567
Score: 0.998
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  2075.45

PubMed score by year
PubTator Score  1255.98

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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