Tchem SMAD3 Mothers against decapentaplegic homolog 3

Protein Summary

Description

Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD3/SMAD4 complex, activates transcription. Also can form a SMAD3/SMAD4/JUN/FOS complex at the AP-1/SMAD site to regulate TGF-beta-mediated transcription. Has an inhibitory effect on wound healing probably by modulating both growth and migration of primary keratinocytes and by altering the TGF-mediated chemotaxis of monocytes. This effect on wound healing appears to be hormone-sensitive. Regulator of chondrogenesis and osteogenesis and inhibits early healing of bone fractures. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator. The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein functions as a transcriptional modulator activated by transforming growth factor-beta and is thought to play a role in the regulation of carcinogenesis. [provided by RefSeq, Apr 2009]

Uniprot Accession IDs

• P84022
• A8K4B6
• B7Z4Z5
• B7Z6M9
• B7Z9Q2
• F5H383
• O09064
• O09144
• O14510
• O35273
• Q92940
• Q93002
• Q9GKR4
• MAD homolog 3

Gene Name

• SMAD3

Ensembl ID

• ENST00000327367
• ENSP00000332973
• ENSG00000166949
• ENST00000439724
• ENSP00000401133
• ENST00000537194
• ENSP00000445348
• ENST00000540846
• ENSP00000437757

Symbol

• MADH3
• LDS3
• LDS1C
• MADH3
• JV15-2
• HSPC193
• HsT17436

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	1
hub protein	1
molecular function	1
biological term	0.99
phosphatase	0.95

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Mothers Against Decapentaplegic Homolog 3

DTO Classes

Protein / Transcription Factor / Mothers Against Decapentaplegic Homolog 3

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2340.96   (req: < 5)

Gene RIFs: 608   (req: <= 3)

Antibodies: 2043   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2340.96   (req: >= 5)

Gene RIFs: 608   (req: > 3)

Antibodies: 2043   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 112

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 4

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0