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Tbio
RPL36A
60S ribosomal protein L36a

Protein Summary
Description
Cytoplasmic ribosomes, organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein, which shares sequence similarity with yeast ribosomal protein L44, belongs to the L44E (L36AE) family of ribosomal proteins. Although this gene has been referred to as ribosomal protein L44 (RPL44), its official name is ribosomal protein L36a (RPL36A). This gene and the human gene officially named ribosomal protein L36a-like (RPL36AL) encode nearly identical proteins; however, they are distinct genes. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Naturally occurring read-through transcription occurs between this locus and the heterogeneous nuclear ribonucleoprotein H2 (H') gene. [p ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000553110
  • ENSP00000446503
  • ENSG00000241343

Symbol
  • RPL44
  • L36A
  • L44L
  • MIG6
  • RPL44
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.93
disease perturbation
0.83
virus perturbation
0.79
microRNA
0.74
biological process
0.72


Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.73   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 123   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.73   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 123   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
60S ribosomal protein L36a-like
709650
Mouse
MGI:1201789
19982
Rat
RGD:1306640
292964
Dog
ribosomal protein L36a like
480311
Cow
ribosomal protein L36a-like
508165
Species
Name
OMA
EggNOG
Inparanoid
Macaque
60S ribosomal protein L36a-like
Mouse
Rat
Dog
ribosomal protein L36a like
Cow
ribosomal protein L36a-like
Protein Structure (6 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P83881-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 6
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (34)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 32
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Cap-dependent Translation Initiation
Reactome
Developmental Biology
Reactome
Disease
Reactome
Eukaryotic Translation Elongation
Name
Explore in Pharos
Explore in Source
Axon guidance
Cap-dependent Translation Initiation
Developmental Biology
Disease
Eukaryotic Translation Elongation
Gene Ontology Terms (13)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Non-traceable Author Statement (NAS)
UniProtKB
Protein-Protein Interactions (319)
1 – 10 of 319
PAGE2B
Tdark
Novelty:  0.70952249
p_int:  0.999890282
p_ni:  0.000097099
p_wrong:  0.000012619
Data Source:  BioPlex
SDAD1
Tdark
Novelty:  0.2574139
p_int:  0.99939509
p_ni:  0.00060491
Data Source:  BioPlex
NAP1L1
Tbio
Novelty:  0.03895314
p_int:  0.889350616
p_ni:  0.110649384
Score:  0.423
Data Source:  BioPlex,STRINGDB
RPL7A
Tbio
Novelty:  0.01674027
Score:  0.999
Data Source:  STRINGDB
RPL9
Tbio
Novelty:  0.00845583
Score:  0.999
Data Source:  STRINGDB
RPS27A
Tbio
Novelty:  0.00658124
Score:  0.999
Data Source:  STRINGDB
RPS5
Tbio
Novelty:  0.00513677
Score:  0.999
Data Source:  STRINGDB
RPL34
Tbio
Novelty:  0.02236592
Score:  0.999
Data Source:  STRINGDB
RPL15
Tbio
Novelty:  0.02466708
Score:  0.999
Data Source:  STRINGDB
RPS18
Tbio
Novelty:  0.00688684
Score:  0.999
Data Source:  STRINGDB
Publication Statistics
PubMed Score  14.73

PubMed score by year
PubTator Score  6.63

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer