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Tbio
COG7
Conserved oligomeric Golgi complex subunit 7

Protein Summary
Description
Required for normal Golgi function. The protein encoded by this gene resides in the golgi, and constitutes one of the 8 subunits of the conserved oligomeric Golgi (COG) complex, which is required for normal golgi morphology and localization. Mutations in this gene are associated with the congenital disorder of glycosylation type IIe.[provided by RefSeq, May 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000307149
  • ENSP00000305442
  • ENSG00000168434

Symbol
  • CDG2E
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.81
cellular component
0.65
tissue sample
0.65
protein complex
0.61
tissue
0.56


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.24   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 186   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.24   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 186   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (181)
COG5
Tbio
Novelty:  0.04017657
p_int:  0.999999923
p_ni:  7.6e-8
p_wrong:  2e-9
Score:  0.999
Data Source:  BioPlex,STRINGDB
COG1
Tbio
Novelty:  0.0124285
p_int:  0.999999676
p_ni:  3.24e-7
Score:  0.999
Data Source:  BioPlex,STRINGDB
COG3
Tbio
Novelty:  0.02746711
p_int:  0.999999619
p_ni:  3.8e-7
p_wrong:  2e-9
Score:  0.999
Data Source:  BioPlex,STRINGDB
COG8
Tbio
Novelty:  0.02448169
p_int:  0.999999509
p_ni:  4.91e-7
Score:  0.999
Data Source:  BioPlex,STRINGDB
COG6
Tbio
Novelty:  0.02874093
p_int:  0.999998
p_ni:  0.000001998
p_wrong:  3e-9
Score:  0.999
Data Source:  BioPlex,STRINGDB
COG2
Tbio
Novelty:  0.03109287
p_int:  0.999996782
p_ni:  0.000003215
p_wrong:  3e-9
Score:  0.999
Data Source:  BioPlex,STRINGDB
PKD2
Tchem
Family:  IC
Novelty:  0.00305329
p_int:  0.999985303
p_ni:  0.000014697
Data Source:  BioPlex
COG4
Tbio
Novelty:  0.03809668
p_int:  0.999977932
p_ni:  0.000022068
Score:  0.999
Data Source:  BioPlex,STRINGDB
COMMD8
Tdark
Novelty:  0.33240242
p_int:  0.999317214
p_ni:  0.000682752
p_wrong:  3.5e-8
Score:  0.67
Data Source:  BioPlex,STRINGDB
DTNBP1
Tbio
Novelty:  0.00341619
p_int:  0.996275957
p_ni:  0.003689793
p_wrong:  0.00003425
Score:  0.597
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (11)
Asparagine N-linked glycosylation (R-HSA-446203)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Asparagine N-linked glycosylation
Reactome
COPI-mediated anterograde transport
Reactome
ER to Golgi Anterograde Transport
Reactome
Intra-Golgi and retrograde Golgi-to-ER traffic
Reactome
Intra-Golgi traffic
Name
Explore in Pharos
Explore in Source
Asparagine N-linked glycosylation
COPI-mediated anterograde transport
ER to Golgi Anterograde Transport
Intra-Golgi and retrograde Golgi-to-ER traffic
Intra-Golgi traffic
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.1
21.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
21.5
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
component of oligomeric golgi complex 7
VGNC:5743
453986
Macaque
component of oligomeric golgi complex 7
700218
Mouse
MGI:2685013
233824
Rat
RGD:1566058
293456
Dog
component of oligomeric golgi complex 7
VGNC:39453
479808
Species
Name
OMA
EggNOG
Inparanoid
Chimp
component of oligomeric golgi complex 7
Macaque
component of oligomeric golgi complex 7
Mouse
Rat
Dog
component of oligomeric golgi complex 7
Publication Statistics
PubMed Score 15.24
PubMed score by year
PubTator Score 10.01
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title