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Tbio
LSM11
U7 snRNA-associated Sm-like protein LSm11

Protein Summary
Description
Component of the U7 snRNP complex that is involved in the histone 3'-end pre-mRNA processing (By similarity). Increases U7 snRNA levels but not histone 3'-end pre-mRNA processing activity, when overexpressed. Required for cell cycle progression from G1 to S phases. Binds specifically to the Sm-binding site of U7 snRNA.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000286307
  • ENSP00000286307
  • ENSG00000155858
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.76
cell type or tissue
0.65
transcription factor binding site profile
0.65
tissue sample
0.62
histone modification site profile
0.55


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.06   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 88   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.06   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 88   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean reticulocyte volume
1
1
1
4.2
mean corpuscular volume
1
1
1
4.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean reticulocyte volume
1
4.2
mean corpuscular volume
1
4.2
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
LSM11, U7 small nuclear RNA associated
VGNC:13541
736032
Mouse
MGI:1919540
72290
Rat
RGD:1565523
501688
Cow
LSM11, U7 small nuclear RNA associated
VGNC:54446
785718
Opossum
LSM11, U7 small nuclear RNA associated
100025371
Species
Name
OMA
EggNOG
Inparanoid
Chimp
LSM11, U7 small nuclear RNA associated
Mouse
Rat
Cow
LSM11, U7 small nuclear RNA associated
Opossum
LSM11, U7 small nuclear RNA associated
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P83369-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (7)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Metabolism of RNA
Reactome
Processing of Capped Intronless Pre-mRNA
Reactome
RNA Polymerase II Transcription
Reactome
RNA Polymerase II Transcription Termination
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Metabolism of RNA
Processing of Capped Intronless Pre-mRNA
RNA Polymerase II Transcription
RNA Polymerase II Transcription Termination
Gene Ontology Terms (11)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Protein-Protein Interactions (67)
1 – 10 of 67
SNRPGP15
Tdark
p_int: 0.999995546
p_ni: 0.000004448
p_wrong: 6e-9
Data Source: BioPlex
SSSCA1
Tdark
Novelty: 0.53523038
p_int: 0.999995272
p_ni: 0.000004728
Data Source: BioPlex
SNRPN
Tbio
Novelty: 0.002157
p_int: 0.999970885
p_ni: 0.000029113
p_wrong: 1e-9
Score: 0.473
Data Source: BioPlex,STRINGDB
SNRPF
Tdark
Novelty: 0.17624854
p_int: 0.999951257
p_ni: 0.000048553
p_wrong: 1.9e-7
Score: 0.972
Data Source: BioPlex,STRINGDB
SNRPE
Tbio
Novelty: 0.02033423
p_int: 0.999915423
p_ni: 0.000084577
Score: 0.976
Data Source: BioPlex,STRINGDB
DDX20
Tbio
Family: Enzyme
Novelty: 0.01854078
p_int: 0.998913153
p_ni: 0.001004283
p_wrong: 0.000082564
Score: 0.883
Data Source: BioPlex,STRINGDB
MRPS17
Tdark
Novelty: 0.46103276
p_int: 0.998117018
p_ni: 0.001806925
p_wrong: 0.000076057
Data Source: BioPlex
LSM10
Tbio
Novelty: 0.16403413
Score: 0.996
Data Source: STRINGDB
SLBP
Tbio
Novelty: 0.00685735
Score: 0.986
Data Source: STRINGDB
ZNF473
Tbio
Family: TF
Novelty: 0.07957644
Score: 0.978
Data Source: STRINGDB
Publication Statistics
PubMed Score  10.06

PubMed score by year
PubTator Score  6.77

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer