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Tbio
RBP5
Retinol-binding protein 5

Protein Summary
Description
Intracellular transport of retinol. The protein encoded by this gene is a cellular retinol-binding protein expressed highly in kidney and liver. Down-regulation of the encoded protein in hepatocellular carcinoma was associated with large tumor size and poor patient survival rates. [provided by RefSeq, Jul 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000266560
  • ENSP00000266560
  • ENSG00000139194

Symbol
  • CRBP3
  • CRBPIII
  • HRBPiso
  • CRBP-III
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
1
pathway
0.88
cell line
0.6
transcription factor
0.6
protein domain
0.58


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.62   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 180   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.62   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 180   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet crit
1
1
1
7.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet crit
1
7.5
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
retinol binding protein 5
VGNC:5567
748121
Macaque
retinol binding protein 5 [Source:HGNC Symbol;Acc:HGNC:15847]
Dog
retinol binding protein 5
VGNC:45433
477706
Horse
retinol binding protein 5
VGNC:22257
100053078
Cow
retinol binding protein 5
VGNC:33816
539418
Species
Name
OMA
EggNOG
Inparanoid
Chimp
retinol binding protein 5
Macaque
retinol binding protein 5 [Source:HGNC Symbol;Acc:HGNC:15847]
Dog
retinol binding protein 5
Horse
retinol binding protein 5
Cow
retinol binding protein 5
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P82980-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Gene Ontology Terms (5)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (21)
1 – 10 of 21
RDH10
Tbio
Family: Enzyme
Novelty: 0.03049914
Score: 0.943
Data Source: STRINGDB
LRAT
Tbio
Family: Enzyme
Novelty: 0.00593203
Score: 0.942
Data Source: STRINGDB
RBP4
Tchem
Novelty: 0.00168442
Score: 0.938
Data Source: STRINGDB
SDR16C5
Tbio
Family: Enzyme
Novelty: 0.11319496
Score: 0.929
Data Source: STRINGDB
RDH8
Tbio
Family: Enzyme
Novelty: 0.06071472
Score: 0.929
Data Source: STRINGDB
RDH11
Tbio
Family: Enzyme
Novelty: 0.02758936
Score: 0.925
Data Source: STRINGDB
RDH12
Tbio
Family: Enzyme
Novelty: 0.016003
Score: 0.919
Data Source: STRINGDB
DHRS3
Tbio
Family: Enzyme
Novelty: 0.04448013
Score: 0.911
Data Source: STRINGDB
PNLIP
Tclin
Family: Enzyme
Novelty: 0.00043254
Score: 0.906
Data Source: STRINGDB
RDH16
Tbio
Family: Enzyme
Novelty: 0.08211372
Score: 0.903
Data Source: STRINGDB
Publication Statistics
PubMed Score  12.62

PubMed score by year
PubTator Score  7.5

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer