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Tbio
MRPS6
28S ribosomal protein S6, mitochondrial

Protein Summary
Description
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S6P family. Pseudogenes corresponding to this gene are found on chromosomes 1p and 12q. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000399312
  • ENSP00000382250
  • ENSG00000243927

Symbol
  • C21orf101
  • RPMS6
  • S6mt
  • RPMS6
  • MRP-S6
  • C21orf101
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
small molecule perturbation
0.91
kinase perturbation
0.84
interacting protein
0.82
virus perturbation
0.79
transcription factor binding site profile
0.69


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.27   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 64   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.27   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 64   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (231)
MRPS34
Tbio
Novelty:  0.29355603
p_int:  0.990734417
p_ni:  0.009265577
p_wrong:  6e-9
Score:  0.973
Data Source:  BioPlex,STRINGDB
MRPS18C
Tdark
Novelty:  0.42868428
p_int:  0.988336613
p_ni:  0.011663387
Score:  0.995
Data Source:  BioPlex,STRINGDB
MRPS18B
Tbio
Novelty:  0.14519418
p_int:  0.983218491
p_ni:  0.016781509
Score:  0.99
Data Source:  BioPlex,STRINGDB
MRPS17
Tdark
Novelty:  0.46103276
p_int:  0.955640653
p_ni:  0.044359347
Score:  0.98
Data Source:  BioPlex,STRINGDB
MRPS15
Tdark
Novelty:  0.37070563
p_int:  0.930615648
p_ni:  0.069384352
Score:  0.999
Data Source:  BioPlex,STRINGDB
MRPS25
Tdark
Novelty:  0.59354314
p_int:  0.861494861
p_ni:  0.138505139
Score:  0.982
Data Source:  BioPlex,STRINGDB
TRA2A
Tbio
Novelty:  0.04935993
p_int:  0.769995111
p_ni:  0.230004889
Score:  0.526
Data Source:  BioPlex,STRINGDB
MRPL9
Tdark
Novelty:  0.43920695
Score:  0.999
Data Source:  STRINGDB
MRPL17
Tdark
Novelty:  1.20541719
Score:  0.999
Data Source:  STRINGDB
MRPS9
Tdark
Novelty:  0.22906484
Score:  0.999
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Mitochondrial translation
Reactome
Mitochondrial translation elongation
Reactome
Mitochondrial translation initiation
Reactome
Mitochondrial translation termination
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Mitochondrial translation
Mitochondrial translation elongation
Mitochondrial translation initiation
Mitochondrial translation termination
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (21)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hemoglobin measurement
3
4
5
95.1
hematocrit
3
3
5
93
heel bone mineral density
2
3
6
90
8
2
3
1.2
80.9
5
2
0
1.1
74.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hemoglobin measurement
5
95.1
hematocrit
5
93
heel bone mineral density
6
90
3
1.2
80.9
0
1.1
74.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
mitochondrial ribosomal protein S6
VGNC:1141
473978
Macaque
mitochondrial ribosomal protein S6 [Source:HGNC Symbol;Acc:HGNC:14051]
Mouse
MGI:2153111
121022
Dog
mitochondrial ribosomal protein S6 [Source:HGNC Symbol;Acc:HGNC:14051]
Horse
mitochondrial ribosomal protein S6
VGNC:20370
100630353
Species
Name
OMA
EggNOG
Inparanoid
Chimp
mitochondrial ribosomal protein S6
Macaque
mitochondrial ribosomal protein S6 [Source:HGNC Symbol;Acc:HGNC:14051]
Mouse
Dog
mitochondrial ribosomal protein S6 [Source:HGNC Symbol;Acc:HGNC:14051]
Horse
mitochondrial ribosomal protein S6
Publication Statistics
PubMed Score 6.27
PubMed score by year
PubTator Score 1.97
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title