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Tbio
MRPS6
28S ribosomal protein S6, mitochondrial

Protein Summary
Description
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S6P family. Pseudogenes corresponding to this gene are found on chromosomes 1p and 12q. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000399312
  • ENSP00000382250
  • ENSG00000243927

Symbol
  • C21orf101
  • RPMS6
  • S6mt
  • RPMS6
  • MRP-S6
  • C21orf101
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
small molecule perturbation
0.91
kinase perturbation
0.84
interacting protein
0.82
virus perturbation
0.79
transcription factor binding site profile
0.69


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 64   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 64   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
mitochondrial ribosomal protein S6
VGNC:1141
473978
Macaque
mitochondrial ribosomal protein S6 [Source:HGNC Symbol;Acc:HGNC:14051]
Mouse
MGI:2153111
121022
Dog
mitochondrial ribosomal protein S6 [Source:HGNC Symbol;Acc:HGNC:14051]
Horse
mitochondrial ribosomal protein S6
VGNC:20370
100630353
Species
Name
OMA
EggNOG
Inparanoid
Chimp
mitochondrial ribosomal protein S6
Macaque
mitochondrial ribosomal protein S6 [Source:HGNC Symbol;Acc:HGNC:14051]
Mouse
Dog
mitochondrial ribosomal protein S6 [Source:HGNC Symbol;Acc:HGNC:14051]
Horse
mitochondrial ribosomal protein S6
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P82932-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (7)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Mitochondrial translation
Reactome
Mitochondrial translation elongation
Reactome
Mitochondrial translation initiation
Reactome
Mitochondrial translation termination
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Mitochondrial translation
Mitochondrial translation elongation
Mitochondrial translation initiation
Mitochondrial translation termination
Protein-Protein Interactions (231)
1 – 10 of 231
MRPS34
Tbio
Novelty: 0.29355603
p_int: 0.990734417
p_ni: 0.009265577
p_wrong: 6e-9
Score: 0.973
Data Source: BioPlex,STRINGDB
MRPS18C
Tdark
Novelty: 0.42868428
p_int: 0.988336613
p_ni: 0.011663387
Score: 0.995
Data Source: BioPlex,STRINGDB
MRPS18B
Tbio
Novelty: 0.14519418
p_int: 0.983218491
p_ni: 0.016781509
Score: 0.99
Data Source: BioPlex,STRINGDB
MRPS17
Tdark
Novelty: 0.46103276
p_int: 0.955640653
p_ni: 0.044359347
Score: 0.98
Data Source: BioPlex,STRINGDB
MRPS15
Tdark
Novelty: 0.37070563
p_int: 0.930615648
p_ni: 0.069384352
Score: 0.999
Data Source: BioPlex,STRINGDB
MRPS25
Tdark
Novelty: 0.59354314
p_int: 0.861494861
p_ni: 0.138505139
Score: 0.982
Data Source: BioPlex,STRINGDB
TRA2A
Tbio
Novelty: 0.04935993
p_int: 0.769995111
p_ni: 0.230004889
Score: 0.526
Data Source: BioPlex,STRINGDB
MRPL9
Tdark
Novelty: 0.43920695
Score: 0.999
Data Source: STRINGDB
MRPL17
Tdark
Novelty: 1.20541719
Score: 0.999
Data Source: STRINGDB
MRPS9
Tdark
Novelty: 0.22906484
Score: 0.999
Data Source: STRINGDB
Publication Statistics
PubMed Score  6.00

PubMed score by year
PubTator Score  1.97

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer