Tbio MRPS6 28S ribosomal protein S6, mitochondrial

Protein Summary

Description

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S6P family. Pseudogenes corresponding to this gene are found on chromosomes 1p and 12q. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P82932
• B2R573
• Q96Q64
• Q9BSK8
• Q9BW89
• MRP-S6

Gene Name

• MRPS6

Ensembl ID

• ENST00000399312
• ENSP00000382250
• ENSG00000243927

Symbol

• C21orf101
• RPMS6
• S6mt
• RPMS6
• MRP-S6
• C21orf101

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
small molecule perturbation	0.91
kinase perturbation	0.84
interacting protein	0.82
virus perturbation	0.79
transcription factor binding site profile	0.69

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.27   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 64   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.27   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 64   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Related Tools

Target Illumination GWAS Analytics (TIGA)

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GENEVA

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Protein-Protein Interactions (231)

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1 – 10 of 231

• See Interactions on String-DB

MRPS34

Tbio

Novelty:  0.29355603

p_int:  0.990734417

p_ni:  0.009265577

p_wrong:  6e-9

Score:  0.973

Data Source:  BioPlex,STRINGDB

MRPS18C

Tdark

Novelty:  0.42868428

p_int:  0.988336613

p_ni:  0.011663387

Score:  0.995

Data Source:  BioPlex,STRINGDB

MRPS18B

Tbio

Novelty:  0.14519418

p_int:  0.983218491

p_ni:  0.016781509

Score:  0.99

Data Source:  BioPlex,STRINGDB

MRPS17

Tdark

Novelty:  0.46103276

p_int:  0.955640653

p_ni:  0.044359347

Score:  0.98

Data Source:  BioPlex,STRINGDB

MRPS15

Tdark

Novelty:  0.37070563

p_int:  0.930615648

p_ni:  0.069384352

Score:  0.999

Data Source:  BioPlex,STRINGDB

MRPS25

Tdark

Novelty:  0.59354314

p_int:  0.861494861

p_ni:  0.138505139

Score:  0.982

Data Source:  BioPlex,STRINGDB

TRA2A

Tbio

Novelty:  0.04935993

p_int:  0.769995111

p_ni:  0.230004889

Score:  0.526

Data Source:  BioPlex,STRINGDB

MRPL9

Tdark

Novelty:  0.43920695

Score:  0.999

Data Source:  STRINGDB

MRPL17

Tdark

Novelty:  1.20541719

Score:  0.999

Data Source:  STRINGDB

MRPS9

Tdark

Novelty:  0.22906484

Score:  0.999

Data Source:  STRINGDB

Pathways (7)

Reactome (6)

KEGG (1)

Metabolism of proteins (R-HSA-392499)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Metabolism of proteins	2050 targets	R-HSA-392499
Reactome	Mitochondrial translation	96 targets	R-HSA-5368287
Reactome	Mitochondrial translation elongation	90 targets	R-HSA-5389840
Reactome	Mitochondrial translation initiation	90 targets	R-HSA-5368286
Reactome	Mitochondrial translation termination	90 targets	R-HSA-5419276

Name	Explore in Pharos	Explore in Source
Metabolism of proteins	2050 targets	R-HSA-392499
Mitochondrial translation	96 targets	R-HSA-5368287
Mitochondrial translation elongation	90 targets	R-HSA-5389840
Mitochondrial translation initiation	90 targets	R-HSA-5368286
Mitochondrial translation termination	90 targets	R-HSA-5419276

Gene Ontology Terms (9)

Functions (2)

Components (3)

Processes (4)

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1 – 2 of 2

GO Term	Evidence	Assigned by
small ribosomal subunit rRNA binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
structural constituent of ribosome	Inferred from Sequence or structural Similarity (ISS)	UniProtKB

GWAS Traits (21)

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1 – 5 of 21

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
hemoglobin measurement	EFO_0004509	3	4	5		95.1
hematocrit	EFO_0004348	3	3	5		93
heel bone mineral density	EFO_0009270	2	3	6		90
coronary artery disease	EFO_0001645	8	2	3	1.2	80.9
myocardial infarction	EFO_0000612	5	2	0	1.1	74.7

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 21

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
hemoglobin measurement	EFO_0004509	5		95.1
hematocrit	EFO_0004348	5		93
heel bone mineral density	EFO_0009270	6		90
coronary artery disease	EFO_0001645	3	1.2	80.9
myocardial infarction	EFO_0000612	0	1.1	74.7

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Complete proteome
Mitochondrion
Reference proteome
Ribonucleoprotein
Ribosomal protein

GWAS Trait Find Similar Targets

No Header	No Header
BMI-adjusted hip circumference
BMI-adjusted waist circumference
BMI-adjusted waist-hip ratio
coronary artery disease
erythrocyte count
erythrocyte measurement
FEV/FEC ratio
gas trapping measurement
glomerular filtration rate
heel bone mineral density

Orthologs (13)

1 – 5 of 13

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	mitochondrial ribosomal protein S6	VGNC:1141	473978
Macaque	mitochondrial ribosomal protein S6 [Source:HGNC Symbol;Acc:HGNC:14051]
Mouse	mitochondrial ribosomal protein S6	MGI:2153111	121022
Dog	mitochondrial ribosomal protein S6 [Source:HGNC Symbol;Acc:HGNC:14051]
Horse	mitochondrial ribosomal protein S6	VGNC:20370	100630353

Species	Name	OMA	EggNOG	Inparanoid
Chimp	mitochondrial ribosomal protein S6
Macaque	mitochondrial ribosomal protein S6 [Source:HGNC Symbol;Acc:HGNC:14051]
Mouse	mitochondrial ribosomal protein S6
Dog	mitochondrial ribosomal protein S6 [Source:HGNC Symbol;Acc:HGNC:14051]
Horse	mitochondrial ribosomal protein S6

Publication Statistics

PubMed Score 6.27

PubMed score by year

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PubTator Score 1.97

PubTator score by year

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