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Tbio
MRPS34
28S ribosomal protein S34, mitochondrial

Protein Summary
Description
Required for mitochondrial translation, plays a role in maintaining the stability of the small ribosomal subunit and the 12S rRNA that are required for mitoribosome formation. Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000397375
  • ENSP00000380531
  • ENSG00000074071

Symbol
  • MRPS12
  • COXPD32
  • MRP-S12
  • MRP-S34
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.98
kinase perturbation
0.76
transcription factor binding site profile
0.65
tissue sample
0.59
histone modification site profile
0.54


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.21   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 260   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.21   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 260   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
mitochondrial ribosomal protein S34
VGNC:5843
746434
Macaque
mitochondrial ribosomal protein S34
702487
Mouse
MGI:1930188
79044
Rat
RGD:1305623
287126
Dog
mitochondrial ribosomal protein S34
VGNC:43422
100856578
Species
Name
OMA
EggNOG
Inparanoid
Chimp
mitochondrial ribosomal protein S34
Macaque
mitochondrial ribosomal protein S34
Mouse
Rat
Dog
mitochondrial ribosomal protein S34
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P82930-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (6)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Mitochondrial translation
Reactome
Mitochondrial translation elongation
Reactome
Mitochondrial translation initiation
Reactome
Mitochondrial translation termination
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Mitochondrial translation
Mitochondrial translation elongation
Mitochondrial translation initiation
Mitochondrial translation termination
Gene Ontology Terms (7)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Mutant Phenotype (IMP)
UniProtKB
Protein-Protein Interactions (176)
1 – 10 of 176
NINL
Tbio
Novelty: 0.00726815
p_int: 0.999989217
p_ni: 0.000010774
p_wrong: 9e-9
Data Source: BioPlex
MRPS27
Tbio
Novelty: 0.22058227
p_int: 0.999972641
p_ni: 0.000027359
Score: 0.988
Data Source: BioPlex,STRINGDB
EPDR1
Tbio
Novelty: 0.03597825
p_int: 0.999945999
p_ni: 0.000053894
p_wrong: 1.06e-7
Data Source: BioPlex
PSMG4
Tdark
Novelty: 0.05339077
p_int: 0.999924654
p_ni: 0.000075341
p_wrong: 5e-9
Score: 0.162
Data Source: BioPlex,STRINGDB
DDX55
Tdark
Family: Enzyme
Novelty: 0.27887497
p_int: 0.999908151
p_ni: 0.000091849
Score: 0.261
Data Source: BioPlex,STRINGDB
NOA1
Tbio
Novelty: 0.01478325
p_int: 0.999828361
p_ni: 0.000171635
p_wrong: 4e-9
Score: 0.588
Data Source: BioPlex,STRINGDB
MRPS33
Tdark
Novelty: 0.27300643
p_int: 0.999819994
p_ni: 0.000180006
Score: 0.991
Data Source: BioPlex,STRINGDB
MRPS31
Tdark
Novelty: 0.28807342
p_int: 0.999808696
p_ni: 0.000191304
Score: 0.989
Data Source: BioPlex,STRINGDB
MRPS35
Tdark
Novelty: 6.44240335
p_int: 0.99965866
p_ni: 0.00034134
Score: 0.985
Data Source: BioPlex,STRINGDB
MRPS9
Tdark
Novelty: 0.22906484
p_int: 0.999615869
p_ni: 0.000384131
Score: 0.976
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  4.21

PubMed score by year
PubTator Score  2.64

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer