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Tdark
MRPS15
28S ribosomal protein S15, mitochondrial

Protein Summary
Description
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S15P family. The encoded protein is more than two times the size of its E. coli counterpart, with the 12S rRNA binding sites conserved. Between human and mouse, the encoded protein is the least conserved among small subunit ribosomal proteins. Pseudogenes corresponding to t ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000373116
  • ENSP00000362208
  • ENSG00000116898

Symbol
  • RPMS15
  • DC37
  • S15mt
  • RPMS15
  • MPR-S15
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.99
histone modification site profile
0.91
interacting protein
0.89
transcription factor binding site profile
0.85
cellular component
0.74


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.62   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 161   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.62   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 161   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
1
1
1
70.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
1
70.5
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
mitochondrial ribosomal protein S15
VGNC:1332
469280
Macaque
mitochondrial ribosomal protein S15
713412
Mouse
MGI:1913657
66407
Rat
RGD:1359675
298517
Dog
mitochondrial ribosomal protein S15
VGNC:43411
475333
Species
Name
OMA
EggNOG
Inparanoid
Chimp
mitochondrial ribosomal protein S15
Macaque
mitochondrial ribosomal protein S15
Mouse
Rat
Dog
mitochondrial ribosomal protein S15
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P82914-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (7)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Mitochondrial translation
Reactome
Mitochondrial translation elongation
Reactome
Mitochondrial translation initiation
Reactome
Mitochondrial translation termination
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Mitochondrial translation
Mitochondrial translation elongation
Mitochondrial translation initiation
Mitochondrial translation termination
Gene Ontology Terms (11)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Protein-Protein Interactions (433)
1 – 10 of 433
MRPS31
Tdark
Novelty: 0.28807342
p_int: 0.999229302
p_ni: 0.000770698
Score: 0.995
Data Source: BioPlex,STRINGDB
MRPS11
Tdark
Novelty: 0.29449255
p_int: 0.999199638
p_ni: 0.000800362
Score: 0.999
Data Source: BioPlex,STRINGDB
MRPS9
Tdark
Novelty: 0.22906484
p_int: 0.998719477
p_ni: 0.001280523
Score: 0.999
Data Source: BioPlex,STRINGDB
MCRS1
Tbio
Novelty: 0.03404119
p_int: 0.998040602
p_ni: 0.001959398
Score: 0.155
Data Source: BioPlex,STRINGDB
MRPS5
Tbio
Novelty: 0.11423336
p_int: 0.996784775
p_ni: 0.003215225
Score: 0.999
Data Source: BioPlex,STRINGDB
MRPS34
Tbio
Novelty: 0.29355603
p_int: 0.996298665
p_ni: 0.003701335
Score: 0.986
Data Source: BioPlex,STRINGDB
MRPS7
Tbio
Novelty: 0.00153134
p_int: 0.992754824
p_ni: 0.007245176
Score: 0.999
Data Source: BioPlex,STRINGDB
MRPS21
Tdark
Novelty: 0.34886873
p_int: 0.992667313
p_ni: 0.007332687
Score: 0.988
Data Source: BioPlex,STRINGDB
MRPS2
Tbio
Novelty: 0.14756204
p_int: 0.992048536
p_ni: 0.007951464
Score: 0.999
Data Source: BioPlex,STRINGDB
MRPS33
Tdark
Novelty: 0.27300643
p_int: 0.989605398
p_ni: 0.010390673
p_wrong: 0.000003929
Score: 0.996
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  1.62

PubMed score by year
PubTator Score  0.58

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer