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Tdark
MRPS11
28S ribosomal protein S11, mitochondrial

Protein Summary
Description
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that contains a high level of sequence similarity with ribosomal protein S11P family members. A pseudogene corresponding to this gene is found on chromosome 20. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000325844
  • ENSP00000317376
  • ENSG00000181991
  • ENST00000353598
  • ENSP00000318054

Symbol
  • RPMS11
  • HCC-2
  • S11mt
  • MRP-S11
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.92
interacting protein
0.91
cell type or tissue
0.84
disease perturbation
0.83
virus perturbation
0.83


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.63   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 246   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.63   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 246   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
mitochondrial ribosomal protein S11
VGNC:1911
453626
Macaque
mitochondrial ribosomal protein S11
697743
Mouse
MGI:1915244
67994
Rat
Dog
mitochondrial ribosomal protein S11
VGNC:43409
488727
Species
Name
OMA
EggNOG
Inparanoid
Chimp
mitochondrial ribosomal protein S11
Macaque
mitochondrial ribosomal protein S11
Mouse
Rat
Dog
mitochondrial ribosomal protein S11
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P82912-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (7)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Mitochondrial translation
Reactome
Mitochondrial translation elongation
Reactome
Mitochondrial translation initiation
Reactome
Mitochondrial translation termination
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Mitochondrial translation
Mitochondrial translation elongation
Mitochondrial translation initiation
Mitochondrial translation termination
Protein-Protein Interactions (433)
1 – 10 of 433
NOA1
Tbio
Novelty: 0.01478325
p_int: 0.99999763
p_ni: 0.000002346
p_wrong: 2.4e-8
Score: 0.636
Data Source: BioPlex,STRINGDB
DCAF5
Tdark
Novelty: 0.39565074
p_int: 0.999982533
p_ni: 0.000017467
Data Source: BioPlex
PCMTD1
Tbio
Family: Enzyme
Novelty: 0.14517534
p_int: 0.999866771
p_ni: 0.000110625
p_wrong: 0.000022604
Score: 0.303
Data Source: BioPlex,STRINGDB
WDTC1
Tbio
Novelty: 0.02300849
p_int: 0.999630925
p_ni: 0.000369075
Score: 0.183
Data Source: BioPlex,STRINGDB
TNIK
Tchem
Family: Kinase
Novelty: 0.02681864
p_int: 0.999615264
p_ni: 0.000348858
p_wrong: 0.000035878
Data Source: BioPlex
MRPS15
Tdark
Novelty: 0.37070563
p_int: 0.999199638
p_ni: 0.000800362
Score: 0.999
Data Source: BioPlex,STRINGDB
DRAP1
Tbio
Novelty: 0.05872031
p_int: 0.998377195
p_ni: 0.000153925
p_wrong: 0.00146888
Score: 0.187
Data Source: BioPlex,STRINGDB
MRPS17
Tdark
Novelty: 0.46103276
p_int: 0.998326457
p_ni: 0.001673543
Score: 0.987
Data Source: BioPlex,STRINGDB
MRPS34
Tbio
Novelty: 0.29355603
p_int: 0.998263305
p_ni: 0.001736695
Score: 0.987
Data Source: BioPlex,STRINGDB
STRBP
Tbio
Novelty: 0.00919158
p_int: 0.998072621
p_ni: 0.001927379
Score: 0.266
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  2.63

PubMed score by year
PubTator Score  40.53

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer