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Tbio
MRPS5
28S ribosomal protein S5, mitochondrial

Protein Summary
Description
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S5P family. Pseudogenes corresponding to this gene are found on chromosomes 4q, 5q, and 18q. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000272418
  • ENSP00000272418
  • ENSG00000144029
  • ENST00000345084
  • ENSP00000341660

Symbol
  • S5mt
  • MRP-S5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.92
transcription factor perturbation
0.91
virus perturbation
0.76
interacting protein
0.73
hub protein
0.67


Related Tools
GENEVA
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.79   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 117   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.79   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 117   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
mitochondrial ribosomal protein S5
VGNC:307
459399
Mouse
MGI:1924971
77721
Rat
RGD:1308318
296134
Dog
mitochondrial ribosomal protein S5
VGNC:43425
475746
Horse
mitochondrial ribosomal protein S5
VGNC:20369
100063102
Species
Name
OMA
EggNOG
Inparanoid
Chimp
mitochondrial ribosomal protein S5
Mouse
Rat
Dog
mitochondrial ribosomal protein S5
Horse
mitochondrial ribosomal protein S5
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P82675-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (7)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Mitochondrial translation
Reactome
Mitochondrial translation elongation
Reactome
Mitochondrial translation initiation
Reactome
Mitochondrial translation termination
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Mitochondrial translation
Mitochondrial translation elongation
Mitochondrial translation initiation
Mitochondrial translation termination
Gene Ontology Terms (7)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (449)
1 – 10 of 449
MRPS18B
Tbio
Novelty: 0.14519418
p_int: 0.99850006
p_ni: 0.00149994
Score: 0.99
Data Source: BioPlex,STRINGDB
MRPS15
Tdark
Novelty: 0.37070563
p_int: 0.996784775
p_ni: 0.003215225
Score: 0.999
Data Source: BioPlex,STRINGDB
MRPS34
Tbio
Novelty: 0.29355603
p_int: 0.996340449
p_ni: 0.003659551
Score: 0.987
Data Source: BioPlex,STRINGDB
MRPS27
Tbio
Novelty: 0.22058227
p_int: 0.994580073
p_ni: 0.005419927
Score: 0.988
Data Source: BioPlex,STRINGDB
MRPS17
Tdark
Novelty: 0.46103276
p_int: 0.993472138
p_ni: 0.006527862
Score: 0.987
Data Source: BioPlex,STRINGDB
MRPS31
Tdark
Novelty: 0.28807342
p_int: 0.993458098
p_ni: 0.006541902
Score: 0.997
Data Source: BioPlex,STRINGDB
MRPS11
Tdark
Novelty: 0.29449255
p_int: 0.993029085
p_ni: 0.006970915
Score: 0.999
Data Source: BioPlex,STRINGDB
TRMT10B
Tdark
Family: Enzyme
Novelty: 0.61950381
p_int: 0.990253533
p_ni: 0.009746467
Score: 0.718
Data Source: BioPlex,STRINGDB
MRPS25
Tdark
Novelty: 0.59354314
p_int: 0.989573304
p_ni: 0.010426696
Score: 0.996
Data Source: BioPlex,STRINGDB
TRA2A
Tbio
Novelty: 0.04935993
p_int: 0.978723184
p_ni: 0.021276814
p_wrong: 2e-9
Score: 0.661
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  8.79

PubMed score by year
PubTator Score  0.68

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer