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Tdark
MRPS35
28S ribosomal protein S35, mitochondrial

Protein Summary
Description
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that has had confusing nomenclature in the literature. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. Pseudogenes corresponding to this gene are found on chromosomes 3p, 5q, and 10q. [provided by RefSeq, Jul 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000081029
  • ENSP00000081029
  • ENSG00000061794
  • ENST00000538315
  • ENSP00000445390

Symbol
  • MRPS28
  • MDS023
  • MRPS28
  • MRP-S28
  • HDCMD11P
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.91
histone modification site profile
0.9
disease perturbation
0.87
transcription factor perturbation
0.84
virus perturbation
0.79


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.91   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 110   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.91   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 110   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
4
1
0
1.1
62.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
62.9
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
mitochondrial ribosomal protein S35
VGNC:5488
738082
Mouse
MGI:2385255
232536
Rat
RGD:1306720
297727
Dog
mitochondrial ribosomal protein S35
VGNC:43423
477660
Horse
mitochondrial ribosomal protein S35 [Source:HGNC Symbol;Acc:HGNC:16635]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
mitochondrial ribosomal protein S35
Mouse
Rat
Dog
mitochondrial ribosomal protein S35
Horse
mitochondrial ribosomal protein S35 [Source:HGNC Symbol;Acc:HGNC:16635]
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P82673-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (6)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Mitochondrial translation
Reactome
Mitochondrial translation elongation
Reactome
Mitochondrial translation initiation
Reactome
Mitochondrial translation termination
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Mitochondrial translation
Mitochondrial translation elongation
Mitochondrial translation initiation
Mitochondrial translation termination
Gene Ontology Terms (7)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (174)
1 – 10 of 174
MRPS34
Tbio
Novelty: 0.29355603
p_int: 0.99965866
p_ni: 0.00034134
Score: 0.985
Data Source: BioPlex,STRINGDB
MRPS18B
Tbio
Novelty: 0.14519418
p_int: 0.997987569
p_ni: 0.002012431
Score: 0.998
Data Source: BioPlex,STRINGDB
TRMT10B
Tdark
Family: Enzyme
Novelty: 0.61950381
p_int: 0.997277311
p_ni: 0.002722689
Score: 0.594
Data Source: BioPlex,STRINGDB
MRPS17
Tdark
Novelty: 0.46103276
p_int: 0.996144794
p_ni: 0.003855205
Score: 0.968
Data Source: BioPlex,STRINGDB
MRPS18C
Tdark
Novelty: 0.42868428
p_int: 0.995258542
p_ni: 0.004741458
Score: 0.995
Data Source: BioPlex,STRINGDB
MRPS31
Tdark
Novelty: 0.28807342
p_int: 0.994244196
p_ni: 0.005755804
Score: 0.999
Data Source: BioPlex,STRINGDB
DAP3
Tbio
Novelty: 0.05551866
p_int: 0.993823424
p_ni: 0.006176576
Score: 0.999
Data Source: BioPlex,STRINGDB
MRPS25
Tdark
Novelty: 0.59354314
p_int: 0.991647632
p_ni: 0.008352368
Score: 0.997
Data Source: BioPlex,STRINGDB
ZBTB48
Tbio
Family: TF
Novelty: 0.07020518
p_int: 0.991007541
p_ni: 0.008992459
Data Source: BioPlex
TRA2A
Tbio
Novelty: 0.04935993
p_int: 0.989653864
p_ni: 0.010346136
Score: 0.239
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  0.91

PubMed score by year
PubTator Score  0.36

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer