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Tdark
MRPS10
28S ribosomal protein S10, mitochondrial

Protein Summary
Description
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S10P family. Pseudogenes corresponding to this gene are found on chromosomes 1q, 3p, and 9p. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000053468
  • ENSP00000053468
  • ENSG00000048544

Symbol
  • MRP-S10
  • PNAS-122
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.99
virus perturbation
0.99
transcription factor perturbation
0.88
transcription factor binding site profile
0.7
disease perturbation
0.62


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.3   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 134   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.3   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 134   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
mitochondrial ribosomal protein S10
VGNC:3491
462694
Macaque
28S ribosomal protein S10, mitochondrial pseudogene
717349
Mouse
MGI:1928139
64657
Rat
RGD:1311516
363187
Dog
mitochondrial ribosomal protein S10
VGNC:43408
474902
Species
Name
OMA
EggNOG
Inparanoid
Chimp
mitochondrial ribosomal protein S10
Macaque
28S ribosomal protein S10, mitochondrial pseudogene
Mouse
Rat
Dog
mitochondrial ribosomal protein S10
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P82664-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (7)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Mitochondrial translation
Reactome
Mitochondrial translation elongation
Reactome
Mitochondrial translation initiation
Reactome
Mitochondrial translation termination
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Mitochondrial translation
Mitochondrial translation elongation
Mitochondrial translation initiation
Mitochondrial translation termination
Protein-Protein Interactions (387)
1 – 10 of 387
MRPS34
Tbio
Novelty: 0.29355603
p_int: 0.99842437
p_ni: 0.00157563
Score: 0.989
Data Source: BioPlex,STRINGDB
MRPS17
Tdark
Novelty: 0.46103276
p_int: 0.994788895
p_ni: 0.005211105
Score: 0.992
Data Source: BioPlex,STRINGDB
MRPS15
Tdark
Novelty: 0.37070563
p_int: 0.988322463
p_ni: 0.011677537
Score: 0.999
Data Source: BioPlex,STRINGDB
DAP3
Tbio
Novelty: 0.05551866
p_int: 0.984452883
p_ni: 0.015547117
Score: 0.999
Data Source: BioPlex,STRINGDB
TRMT10B
Tdark
Family: Enzyme
Novelty: 0.61950381
p_int: 0.982009555
p_ni: 0.017990445
Score: 0.716
Data Source: BioPlex,STRINGDB
MRPS18C
Tdark
Novelty: 0.42868428
p_int: 0.981942495
p_ni: 0.018057505
Score: 0.997
Data Source: BioPlex,STRINGDB
MRPS27
Tbio
Novelty: 0.22058227
p_int: 0.978510314
p_ni: 0.021489686
Score: 0.987
Data Source: BioPlex,STRINGDB
MRPS18B
Tbio
Novelty: 0.14519418
p_int: 0.974249002
p_ni: 0.025750998
Score: 0.995
Data Source: BioPlex,STRINGDB
MRPS31
Tdark
Novelty: 0.28807342
p_int: 0.951179323
p_ni: 0.048820677
Score: 0.998
Data Source: BioPlex,STRINGDB
MRPS25
Tdark
Novelty: 0.59354314
p_int: 0.947444359
p_ni: 0.052555641
Score: 0.996
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  4.30

PubMed score by year
PubTator Score  0.13

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer