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Tdark
MRPS25
28S ribosomal protein S25, mitochondrial

Protein Summary
Description
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein. A pseudogene corresponding to this gene is found on chromosome 4. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000253686
  • ENSP00000253686
  • ENSG00000131368
  • ENST00000444840
  • ENSP00000407733
  • ENST00000449354
  • ENSP00000390882

Symbol
  • RPMS25
  • RPMS25
  • MRP-S25
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.94
virus perturbation
0.88
disease perturbation
0.87
tissue sample
0.61
histone modification site profile
0.6


Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.4   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 239   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.4   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 239   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
mitochondrial ribosomal protein S25
VGNC:2430
100614995
Macaque
mitochondrial ribosomal protein S25
703261
Mouse
MGI:1928140
64658
Rat
RGD:1308770
297459
Dog
mitochondrial ribosomal protein S25
VGNC:43416
476523
Species
Name
OMA
EggNOG
Inparanoid
Chimp
mitochondrial ribosomal protein S25
Macaque
mitochondrial ribosomal protein S25
Mouse
Rat
Dog
mitochondrial ribosomal protein S25
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P82663-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (6)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Mitochondrial translation
Reactome
Mitochondrial translation elongation
Reactome
Mitochondrial translation initiation
Reactome
Mitochondrial translation termination
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Mitochondrial translation
Mitochondrial translation elongation
Mitochondrial translation initiation
Mitochondrial translation termination
Gene Ontology Terms (6)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (134)
1 – 10 of 134
NOA1
Tbio
Novelty:  0.01478325
p_int:  0.999954346
p_ni:  0.000045638
p_wrong:  1.6e-8
Data Source:  BioPlex
MRPS33
Tdark
Novelty:  0.27300643
p_int:  0.999309903
p_ni:  0.000690097
Score:  0.996
Data Source:  BioPlex,STRINGDB
PDSS2
Tbio
Family:  Enzyme
Novelty:  0.02716477
p_int:  0.998480179
p_ni:  0.001514748
p_wrong:  0.000005073
Data Source:  BioPlex
MRPS21
Tdark
Novelty:  0.34886873
p_int:  0.998404393
p_ni:  0.001595607
Score:  0.983
Data Source:  BioPlex,STRINGDB
GTPBP8
Tdark
Novelty:  4.38933188
p_int:  0.997651724
p_ni:  0.001646843
p_wrong:  0.000701432
Data Source:  BioPlex
ZBTB48
Tbio
Family:  TF
Novelty:  0.07020518
p_int:  0.996161038
p_ni:  0.003779323
p_wrong:  0.000059639
Data Source:  BioPlex
MRPS24
Tdark
Novelty:  0.68432327
p_int:  0.995974806
p_ni:  0.004025194
Score:  0.987
Data Source:  BioPlex,STRINGDB
MRPS9
Tdark
Novelty:  0.22906484
p_int:  0.995579521
p_ni:  0.004420479
Score:  0.996
Data Source:  BioPlex,STRINGDB
MRPS2
Tbio
Novelty:  0.14756204
p_int:  0.99551694
p_ni:  0.00448306
Score:  0.987
Data Source:  BioPlex,STRINGDB
DAP3
Tbio
Novelty:  0.05551866
p_int:  0.99391463
p_ni:  0.00608537
Score:  0.988
Data Source:  BioPlex,STRINGDB
Publication Statistics
PubMed Score  1.40

PubMed score by year
PubTator Score  1

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer