Tbio MRPS22 28S ribosomal protein S22, mitochondrial

Protein Summary

Description

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that does not seem to have a counterpart in prokaryotic and fungal-mitochondrial ribosomes. This gene lies telomeric of and is transcribed in the opposite direction from the forkhead box L2 gene. A pseudogene corresponding to this gene is found on chromosome Xq. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P82650
• Q9H3I1
• MRP-S22

Gene Name

• MRPS22

Ensembl ID

• ENST00000310776
• ENSP00000310785
• ENSG00000175110
• ENST00000495075
• ENSP00000418008
• ENST00000498505
• ENSP00000420482

Symbol

• C3orf5
• RPMS22
• GIBT
• ODG7
• GK002
• C3orf5
• COXPD5
• RPMS22
• MRP-S22

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	0.98
virus perturbation	0.96
disease perturbation	0.9
kinase perturbation	0.84
gene perturbation	0.71

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.55   (req: < 5)

Gene RIFs: 5   (req: <= 3)

Antibodies: 157   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.55   (req: >= 5)

Gene RIFs: 5   (req: > 3)

Antibodies: 157   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0