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Tbio
MRPS22
28S ribosomal protein S22, mitochondrial

Protein Summary
Description
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that does not seem to have a counterpart in prokaryotic and fungal-mitochondrial ribosomes. This gene lies telomeric of and is transcribed in the opposite direction from the forkhead box L2 gene. A pseudogene corresponding to this gene is found on chromosome Xq. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000310776
  • ENSP00000310785
  • ENSG00000175110
  • ENST00000495075
  • ENSP00000418008
  • ENST00000498505
  • ENSP00000420482

Symbol
  • C3orf5
  • RPMS22
  • GIBT
  • ODG7
  • GK002
  • C3orf5
  • COXPD5
  • RPMS22
  • MRP-S22
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.98
virus perturbation
0.96
disease perturbation
0.9
kinase perturbation
0.84
gene perturbation
0.71


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.37   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 157   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.37   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 157   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
balding measurement
2
6
6
99.8
Alopecia
1
3
3
82.9
2
1
1
1.2
76.8
1
1
0
1.3
75.2
lobe attachment
1
1
1
75.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
balding measurement
6
99.8
Alopecia
3
82.9
1
1.2
76.8
0
1.3
75.2
lobe attachment
1
75.1
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
mitochondrial ribosomal protein S22
VGNC:2429
743553
Macaque
mitochondrial ribosomal protein S22
715845
Mouse
MGI:1928137
64655
Rat
RGD:1585674
683519
Dog
mitochondrial ribosomal protein S22
609331
Species
Name
OMA
EggNOG
Inparanoid
Chimp
mitochondrial ribosomal protein S22
Macaque
mitochondrial ribosomal protein S22
Mouse
Rat
Dog
mitochondrial ribosomal protein S22
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P82650-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (6)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Mitochondrial translation
Reactome
Mitochondrial translation elongation
Reactome
Mitochondrial translation initiation
Reactome
Mitochondrial translation termination
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Mitochondrial translation
Mitochondrial translation elongation
Mitochondrial translation initiation
Mitochondrial translation termination
Gene Ontology Terms (7)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
MGI
Protein-Protein Interactions (173)
1 – 10 of 173
MRPS34
Tbio
Novelty: 0.29355603
p_int: 0.996878223
p_ni: 0.003121777
Score: 0.992
Data Source: BioPlex,STRINGDB
MRPS18B
Tbio
Novelty: 0.14519418
p_int: 0.982102925
p_ni: 0.017897075
Score: 0.999
Data Source: BioPlex,STRINGDB
MRPS17
Tdark
Novelty: 0.46103276
p_int: 0.977473753
p_ni: 0.022526247
Score: 0.99
Data Source: BioPlex,STRINGDB
MRPS27
Tbio
Novelty: 0.22058227
p_int: 0.975830154
p_ni: 0.024169846
Score: 0.993
Data Source: BioPlex,STRINGDB
MRPS25
Tdark
Novelty: 0.59354314
p_int: 0.970677041
p_ni: 0.029322959
Score: 0.997
Data Source: BioPlex,STRINGDB
MRPS18C
Tdark
Novelty: 0.42868428
p_int: 0.935746964
p_ni: 0.064253036
Score: 0.988
Data Source: BioPlex,STRINGDB
RPL6
Tbio
Novelty: 0.01742007
p_int: 0.924647336
p_ni: 0.075352664
Score: 0.616
Data Source: BioPlex,STRINGDB
NOP53
Tbio
Novelty: 0.00353077
p_int: 0.863273296
p_ni: 0.136726704
Data Source: BioPlex
MRPS15
Tdark
Novelty: 0.37070563
p_int: 0.849815679
p_ni: 0.150184321
Score: 0.998
Data Source: BioPlex,STRINGDB
TRA2A
Tbio
Novelty: 0.04935993
p_int: 0.826692989
p_ni: 0.173307011
Score: 0.261
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  13.37

PubMed score by year
PubTator Score  38.48

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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